Imperial College London
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Dr Rodrigo M. Carrillo Larco

Faculty of Medicine, School of Public Health

 
 
 
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r.carrillo-larco CV

 
 
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Location

 

Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Carrillo:2021:10.12688/f1000research.73900.1,
author = {Carrillo, Larco R},
doi = {10.12688/f1000research.73900.1},
journal = {F1000Research},
pages = {1--12},
title = {Blood pressure and 10-year all-cause mortality: Findings fromthe PERU MIGRANT Study},
url = {http://dx.doi.org/10.12688/f1000research.73900.1},
volume = {10},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundThe long-term impact of elevated blood pressure on mortality outcomes has been recently revisited due to proposed changes in cut-offs for hypertension. This study aimed at assessing the association between high blood pressure levels and 10-year mortality using the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC-7) and the American College of Cardiology and the American Heart Association (ACC/AHA) 2017 blood pressure guidelines.MethodsData analysis of the PERU MIGRANT Study, a prospective ongoing cohort, was used. The outcome of interest was 10-year all-cause mortality, and exposures were blood pressure categories according to the JNC-7 and ACC/AHA 2017 guidelines. Log-rank test, Kaplan-Meier and Cox regression models were used to assess the associations of interest controlling for confounders. Hazard ratios (HR) and 95% confidence intervals (95% CI) were estimated.ResultsA total of 976 records, mean age of 60.4 (SD: 11.4), 513 (52.6%) women, were analyzed. Hypertension prevalence at baseline almost doubled from 16.0% (95% CI 13.7%–18.4%) to 31.3% (95% CI 28.4%–34.3%), using the JNC-7 and ACC/AHA 2017 definitions, respectively. Sixty three (6.4%) participants died during the 10-year follow-up, equating to a mortality rate of 3.6 (95% CI 2.4–4.7) per 1000 person-years. Using JNC-7, and compared to those with normal blood pressure, those with pre-hypertension and hypertension had 2.1-fold and 5.1-fold increased risk of death, respectively. Similar mortality effect sizes were estimated using ACC/AHA 2017 for stage-1 and stage-2 hypertension.ConclusionsBlood pressure levels under two different definitions increased the risk of 10-year all-cause mortality. Hypertension prevalence doubled using ACC/AHA 2017 compared to JNC-7. The choice of blood pressure cut-offs to classify hypertension categories need to be balanced against the patients benefit and the capacities of
AU  - Carrillo,Larco R
DO  - 10.12688/f1000research.73900.1
EP  - 12
PY  - 2021///
SN  - 2046-1402
SP  - 1
TI  - Blood pressure and 10-year all-cause mortality: Findings fromthe PERU MIGRANT Study
T2  - F1000Research
UR  - http://dx.doi.org/10.12688/f1000research.73900.1
UR  - https://f1000research.com/articles/10-1134
UR  - http://hdl.handle.net/10044/1/92891
VL  - 10
ER  -
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