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@article{Chowdhury:2018:10.1038/s41598-018-25170-9,
author = {Chowdhury, RA and Tzortzis, KN and Dupont, E and Selvadurai, S and Perbellini, F and Cantwell, C and Ng, FS and Simon, A and Terracciano, C and Peters, NS},
doi = {10.1038/s41598-018-25170-9},
journal = {Scientific Reports},
title = {Concurrent micro- to macro-cardiac electrophysiology in myocyte cultures and human heart slices},
url = {http://dx.doi.org/10.1038/s41598-018-25170-9},
volume = {8},
year = {2018}
}

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TY  - JOUR
AB  - The contact cardiac electrogram is derived from the extracellular manifestation of cellular action potentials and cell-to-cell communication. It is used to guide catheter based clinical procedures. Theoretically, the contact electrogram and the cellular action potential are directly related, and should change in conjunction with each other during arrhythmogenesis, however there is currently no methodology by which to concurrently record both electrograms and action potentials in the same preparation for direct validation of their relationships and their direct mechanistic links. We report a novel dual modality apparatus for concurrent electrogram and cellular action potential recording at a single cell level within multicellular preparations. We further demonstrate the capabilities of this system to validate the direct link between these two modalities of voltage recordings.
AU  - Chowdhury,RA
AU  - Tzortzis,KN
AU  - Dupont,E
AU  - Selvadurai,S
AU  - Perbellini,F
AU  - Cantwell,C
AU  - Ng,FS
AU  - Simon,A
AU  - Terracciano,C
AU  - Peters,NS
DO  - 10.1038/s41598-018-25170-9
PY  - 2018///
SN  - 2045-2322
TI  - Concurrent micro- to macro-cardiac electrophysiology in myocyte cultures and human heart slices
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-018-25170-9
UR  - http://hdl.handle.net/10044/1/59165
VL  - 8
ER  -

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