Imperial College London
Alternate

ProfessorRichardCraster

Faculty of Natural Sciences

Dean of the Faculty of Natural Sciences
 
 
 
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Contact

 

+44 (0)20 7594 8554r.craster Website

 
 
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Assistant

 

Miss Hannah Cline +44 (0)20 7594 1934

 
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Location

 

3.05Faculty BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Puvirajesinghe:2018:10.1098/rsif.2017.0949,
author = {Puvirajesinghe, TM and Zhi, ZL and Craster, RV and Guenneau, S},
doi = {10.1098/rsif.2017.0949},
journal = {Journal of the Royal Society Interface},
title = {Tailoring drug release rates in hydrogel-based therapeutic delivery applications using graphene oxide},
url = {http://dx.doi.org/10.1098/rsif.2017.0949},
volume = {15},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Graphene oxide (GO) is increasingly used for controlling mass diffusion in hydrogel-based drug delivery applications. On the macro-scale, the density of GO in the hydrogel is a critical parameter for modulating drug release. Here, we investigate the diffusion of a peptide drug through a network of GO membranes and GO-embedded hydrogels, modelled as porous matrices resembling both laminated and 'house of cards' structures. Our experiments use a therapeutic peptide and show a tunable nonlinear dependence of the peptide concentration upon time. We establish models using numerical simulations with a diffusion equation accounting for the photo-thermal degradation of fluorophores and an effective percolation model to simulate the experimental data. The modelling yields an interpretation of the control of drug diffusion through GO membranes, which is extended to the diffusion of the peptide in GO-embedded agarose hydrogels. Varying the density of micron-sized GO flakes allows for fine control of the drug diffusion. We further show that both GO density and size influence the drug release rate. The ability to tune the density of hydrogel-like GO membranes to control drug release rates has exciting implications to offer guidelines for tailoring drug release rates in hydrogel-based therapeutic delivery applications.
AU  - Puvirajesinghe,TM
AU  - Zhi,ZL
AU  - Craster,RV
AU  - Guenneau,S
DO  - 10.1098/rsif.2017.0949
PY  - 2018///
SN  - 1742-5662
TI  - Tailoring drug release rates in hydrogel-based therapeutic delivery applications using graphene oxide
T2  - Journal of the Royal Society Interface
UR  - http://dx.doi.org/10.1098/rsif.2017.0949
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29445040
UR  - http://hdl.handle.net/10044/1/57468
VL  - 15
ER  -
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