Imperial College London

DrRobertEndres

Faculty of Natural SciencesDepartment of Life Sciences

Reader in Systems Biology
 
 
 
//

Contact

 

+44 (0)20 7594 9537r.endres Website

 
 
//

Location

 

303Sir Ernst Chain BuildingSouth Kensington Campus

//

Summary

 

Publications

Publication Type
Year
to

68 results found

Ding SS, Schumacher LJ, Javer AE, Endres RG, Brown AEet al., 2019, Shared behavioral mechanisms underlie C. elegans aggregation and swarming., Elife, Vol: 8

In complex biological systems, simple individual-level behavioral rules can give rise to emergent group-level behavior. While collective behavior has been well studied in cells and larger organisms, the mesoscopic scale is less understood, as it is unclear which sensory inputs and physical processes matter a priori. Here, we investigate collective feeding in the roundworm C. elegans at this intermediate scale, using quantitative phenotyping and agent-based modeling to identify behavioral rules underlying both aggregation and swarming-a dynamic phenotype only observed at longer timescales. Using fluorescence multi-worm tracking, we quantify aggregation in terms of individual dynamics and population-level statistics. Then we use agent-based simulations and approximate Bayesian inference to identify three key behavioral rules for aggregation: cluster-edge reversals, a density-dependent switch between crawling speeds, and taxis towards neighboring worms. Our simulations suggest that swarming is simply driven by local food depletion but otherwise employs the same behavioral mechanisms as the initial aggregation.

JOURNAL ARTICLE

Lopez-Garrido J, Ojkic N, Khanna K, Wagner FR, Villa E, Endres RG, Pogliano Ket al., 2018, Chromosome Translocation Inflates Bacillus Forespores and Impacts Cellular Morphology, CELL, Vol: 172, Pages: 758-+, ISSN: 0092-8674

JOURNAL ARTICLE

Micali G, Colin R, Sourjik V, Endres RGet al., 2017, Drift and Behavior of E. coli Cells, BIOPHYSICAL JOURNAL, Vol: 113, Pages: 2321-2325, ISSN: 0006-3495

JOURNAL ARTICLE

Richards DM, Endres RG, 2017, How cells engulf: a review of theoretical approaches to phagocytosis, REPORTS ON PROGRESS IN PHYSICS, Vol: 80, ISSN: 0034-4885

JOURNAL ARTICLE

Yap L-W, Endres RG, 2017, A model of cell-wall dynamics during sporulation in Bacillus subtilis, SOFT MATTER, Vol: 13, Pages: 8089-8095, ISSN: 1744-683X

JOURNAL ARTICLE

Endres RG, 2017, Entropy production selects nonequilibrium states in multistable systems, SCIENTIFIC REPORTS, Vol: 7, ISSN: 2045-2322

JOURNAL ARTICLE

Schumacher LJ, Ding S, Brown AEX, Endres RGet al., 2017, Collective feeding in C. elegans, 19th IUPAB Congress / 11th EBSA Congress, Publisher: SPRINGER, Pages: S74-S74, ISSN: 0175-7571

CONFERENCE PAPER

Schumacher LJ, Ding S, Brown AEX, Endres RGet al., 2017, Collective feeding in C-elegans, 19th IUPAB Congress / 11th EBSA Congress, Publisher: Springer (part of Springer Nature), Pages: S74-S74, ISSN: 0175-7571

CONFERENCE PAPER

Rotrattanadumrong R, Endres RG, 2017, Emergence of cooperativity in a model biofilm, JOURNAL OF PHYSICS D-APPLIED PHYSICS, Vol: 50, ISSN: 0022-3727

JOURNAL ARTICLE

De Palo G, Yi D, Endres RG, 2017, A critical-like collective state leads to long-range cell communication in Dictyostelium discoideum aggregation, PLOS BIOLOGY, Vol: 15, ISSN: 1545-7885

JOURNAL ARTICLE

Ojkic N, Lopez-Garrido J, Pogliano K, Endres RGet al., 2016, Cell-wall remodeling drives engulfment during Bacillus subtiliss porulation, ELIFE, Vol: 5, ISSN: 2050-084X

JOURNAL ARTICLE

Richards DM, Endres RG, 2016, Target shape dependence in a simple model of receptor-mediated endocytosis and phagocytosis, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 113, Pages: 6113-6118, ISSN: 0027-8424

JOURNAL ARTICLE

Micali G, Endres RG, 2016, Bacterial chemotaxis: information processing, thermodynamics, and behavior, CURRENT OPINION IN MICROBIOLOGY, Vol: 30, Pages: 8-15, ISSN: 1369-5274

JOURNAL ARTICLE

Aquino G, Wingreen NS, Endres RG, 2016, Know the Single-Receptor Sensing Limit? Think Again, JOURNAL OF STATISTICAL PHYSICS, Vol: 162, Pages: 1353-1364, ISSN: 0022-4715

JOURNAL ARTICLE

Eismann S, Endres RG, 2015, Protein Connectivity in Chemotaxis Receptor Complexes, PLOS COMPUTATIONAL BIOLOGY, Vol: 11, ISSN: 1553-734X

JOURNAL ARTICLE

Micali G, Aquino G, Richards DM, Endres RGet al., 2015, Accurate Encoding and Decoding by Single Cells: Amplitude Versus Frequency Modulation, PLOS COMPUTATIONAL BIOLOGY, Vol: 11, ISSN: 1553-734X

JOURNAL ARTICLE

Endres RG, 2015, Bistability: Requirements on Cell-Volume, Protein Diffusion, and Thermodynamics, PLOS ONE, Vol: 10, ISSN: 1932-6203

JOURNAL ARTICLE

Fan S, Endres RG, 2014, A minimal model for metabolism-dependent chemotaxis in Rhodobacter sphaeroides, INTERFACE FOCUS, Vol: 4, ISSN: 2042-8898

JOURNAL ARTICLE

Richards DM, Endres RG, 2014, The Mechanism of Phagocytosis: Two Stages of Engulfment, BIOPHYSICAL JOURNAL, Vol: 107, Pages: 1542-1553, ISSN: 0006-3495

JOURNAL ARTICLE

Ojkic N, Lopez-Garrido J, Pogliano K, Endres RGet al., 2014, Bistable Forespore Engulfment in Bacillus subtilis by a Zipper Mechanism in Absence of the Cell Wall, PLOS COMPUTATIONAL BIOLOGY, Vol: 10, ISSN: 1553-734X

JOURNAL ARTICLE

Clausznitzer D, Micali G, Neumann S, Sourjik V, Endres RGet al., 2014, Predicting Chemical Environments of Bacteria from Receptor Signaling, PLOS COMPUTATIONAL BIOLOGY, Vol: 10, ISSN: 1553-734X

JOURNAL ARTICLE

Aquino G, Tweedy L, Heinrich D, Endres RGet al., 2014, Memory improves precision of cell sensing in fluctuating environments, SCIENTIFIC REPORTS, Vol: 4, ISSN: 2045-2322

JOURNAL ARTICLE

Pageon SV, Aquino G, Lagrue K, Koehler K, Endres RG, Davis DMet al., 2013, Dynamics of Natural Killer Cell Receptor Revealed by Quantitative Analysis of Photoswitchable Protein, BIOPHYSICAL JOURNAL, Vol: 105, Pages: 1987-1996, ISSN: 0006-3495

JOURNAL ARTICLE

De Palo G, Endres RG, 2013, Unraveling Adaptation in Eukaryotic Pathways: Lessons from Protocells, PLOS COMPUTATIONAL BIOLOGY, Vol: 9, ISSN: 1553-7358

JOURNAL ARTICLE

Tweedy L, Meier B, Stephan J, Heinrich D, Endres RGet al., 2013, Distinct cell shapes determine accurate chemotaxis, SCIENTIFIC REPORTS, Vol: 3, ISSN: 2045-2322

JOURNAL ARTICLE

Raymond B, Young JC, Pallett M, Endres RG, Clements A, Frankel Get al., 2013, Subversion of trafficking, apoptosis, and innate immunity by type III secretion system effectors, TRENDS IN MICROBIOLOGY, Vol: 21, Pages: 430-439, ISSN: 0966-842X

JOURNAL ARTICLE

Endres RG, 2013, Physical Principles in Sensing and Signaling, Publisher: OUP Oxford, ISBN: 9780199600632

The book addresses how biological cells work, and specifically achieve their remarkable sensing and signaling properties using insights from physics and engineering.

BOOK

Dart AE, Tollis S, Bright MD, Frankel G, Endres RGet al., 2012, The motor protein myosin 1G functions in Fc gamma R-mediated phagocytosis, JOURNAL OF CELL SCIENCE, Vol: 125, Pages: 6020-6029, ISSN: 0021-9533

JOURNAL ARTICLE

Endres RG, 2012, Signaling Crosstalk: New Insights Require New Vocabulary, BIOPHYSICAL JOURNAL, Vol: 103, Pages: 2241-2242, ISSN: 0006-3495

JOURNAL ARTICLE

Endres RG, 2012, Intracellular chemical gradients: morphing principle in bacteria, BMC BIOPHYSICS, Vol: 5, ISSN: 2046-1682

JOURNAL ARTICLE

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://wlsprd.imperial.ac.uk:80/respub/WEB-INF/jsp/search-html.jsp Request URI: /respub/WEB-INF/jsp/search-html.jsp Query String: respub-action=search.html&id=00534482&limit=30&person=true