Imperial College London

DrRobertEndres

Faculty of Natural SciencesDepartment of Life Sciences

Reader in Systems Biology
 
 
 
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Contact

 

+44 (0)20 7594 9537r.endres Website

 
 
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Location

 

303Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

64 results found

Endres RG, Entropy production selects nonequilibrium states in multistable systems, Scientific Reports, ISSN: 2045-2322

JOURNAL ARTICLE

Endres RG, Micali G, Colin R, Sourjik Vet al., Drift and behavior of E. coli cells, Biophysical Journal, ISSN: 0006-3495

JOURNAL ARTICLE

Endres RG, Yap L, A model of cell-wall dynamics during sporulation in Bacillus subtilis, Soft Matter, ISSN: 1744-683X

JOURNAL ARTICLE

Richards DM, Endres RG, 2017, How cells engulf: a review of theoretical approaches to phagocytosis., Rep Prog Phys

Phagocytosis is a fascinating process whereby a cell surrounds and engulfs particles such as bacteria and dead cells. This is crucial both for single-cell organisms (as a way of acquiring nutrients) and as part of the immune system (to destroy foreign invaders). This whole process is hugely complex and involves multiple coordinated events such as membrane remodelling, receptor motion, cytoskeleton reorganisation and intracellular signalling. Because of this, phagocytosis is an excellent system for theoretical study, benefiting from biophysical approaches combined with mathematical modelling. Here, we review these theoretical approaches and discuss the recent mathematical and computational models, including models based on receptors, models focusing on the forces involved, and models employing energetic considerations. Along the way, we highlight a beautiful connection to the physics of phase transitions, consider the role of stochasticity, and examine links between phagocytosis and other types of endocytosis. We cover the recently discovered multistage nature of phagocytosis, showing that the size of the phagocytic cup grows in distinct stages, with an initial slow stage followed by a much quicker second stage starting around half engulfment. We also address the issue of target shape dependence, which is relevant to both pathogen infection and drug delivery, covering both one-dimensional and two-dimensional results. Throughout, we pay particular attention to recent experimental techniques that continue to inform the theoretical studies and provide a means to test model predictions. Finally, we discuss population models, connections to other biological processes, and how physics and modelling will continue to play a key role in future work in this area.

JOURNAL ARTICLE

Rotrattanadumrong R, Endres RG, 2017, Emergence of cooperativity in a model biofilm, JOURNAL OF PHYSICS D-APPLIED PHYSICS, Vol: 50, ISSN: 0022-3727

JOURNAL ARTICLE

Aquino G, Wingreen NS, Endres RG, 2016, Know the Single-Receptor Sensing Limit? Think Again, JOURNAL OF STATISTICAL PHYSICS, Vol: 162, Pages: 1353-1364, ISSN: 0022-4715

JOURNAL ARTICLE

Micali G, Endres RG, 2016, Bacterial chemotaxis: information processing, thermodynamics, and behavior, CURRENT OPINION IN MICROBIOLOGY, Vol: 30, Pages: 8-15, ISSN: 1369-5274

JOURNAL ARTICLE

Ojkic N, Lopez-Garrido J, Pogliano K, Endres RGet al., 2016, Cell-wall remodeling drives engulfment during Bacillus subtiliss porulation, ELIFE, Vol: 5, ISSN: 2050-084X

JOURNAL ARTICLE

Richards DM, Endres RG, 2016, Target shape dependence in a simple model of receptor-mediated endocytosis and phagocytosis, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 113, Pages: 6113-6118, ISSN: 0027-8424

JOURNAL ARTICLE

Eismann S, Endres RG, 2015, Protein Connectivity in Chemotaxis Receptor Complexes, PLOS COMPUTATIONAL BIOLOGY, Vol: 11, ISSN: 1553-734X

JOURNAL ARTICLE

Endres RG, 2015, Bistability: Requirements on Cell-Volume, Protein Diffusion, and Thermodynamics, PLOS ONE, Vol: 10, ISSN: 1932-6203

JOURNAL ARTICLE

Micali G, Aquino G, Richards DM, Endres RGet al., 2015, Accurate Encoding and Decoding by Single Cells: Amplitude Versus Frequency Modulation, PLOS COMPUTATIONAL BIOLOGY, Vol: 11, ISSN: 1553-734X

JOURNAL ARTICLE

Aquino G, Tweedy L, Heinrich D, Endres RGet al., 2014, Memory improves precision of cell sensing in fluctuating environments, SCIENTIFIC REPORTS, Vol: 4, ISSN: 2045-2322

JOURNAL ARTICLE

Clausznitzer D, Micali G, Neumann S, Sourjik V, Endres RGet al., 2014, Predicting Chemical Environments of Bacteria from Receptor Signaling, PLOS COMPUTATIONAL BIOLOGY, Vol: 10, ISSN: 1553-734X

JOURNAL ARTICLE

Fan S, Endres RG, 2014, A minimal model for metabolism-dependent chemotaxis in Rhodobacter sphaeroides, INTERFACE FOCUS, Vol: 4, ISSN: 2042-8898

JOURNAL ARTICLE

Ojkic N, Lopez-Garrido J, Pogliano K, Endres RGet al., 2014, Bistable Forespore Engulfment in Bacillus subtilis by a Zipper Mechanism in Absence of the Cell Wall, PLOS COMPUTATIONAL BIOLOGY, Vol: 10, ISSN: 1553-734X

JOURNAL ARTICLE

Richards DM, Endres RG, 2014, The Mechanism of Phagocytosis: Two Stages of Engulfment, BIOPHYSICAL JOURNAL, Vol: 107, Pages: 1542-1553, ISSN: 0006-3495

JOURNAL ARTICLE

De Palo G, Endres RG, 2013, Unraveling Adaptation in Eukaryotic Pathways: Lessons from Protocells, PLOS COMPUTATIONAL BIOLOGY, Vol: 9, ISSN: 1553-7358

JOURNAL ARTICLE

Endres RG, 2013, Physical Principles in Sensing and Signaling, Publisher: OUP Oxford, ISBN: 9780199600632

The book addresses how biological cells work, and specifically achieve their remarkable sensing and signaling properties using insights from physics and engineering.

BOOK

Pageon SV, Aquino G, Lagrue K, Koehler K, Endres RG, Davis DMet al., 2013, Dynamics of Natural Killer Cell Receptor Revealed by Quantitative Analysis of Photoswitchable Protein, BIOPHYSICAL JOURNAL, Vol: 105, Pages: 1987-1996, ISSN: 0006-3495

JOURNAL ARTICLE

Raymond B, Young JC, Pallett M, Endres RG, Clements A, Frankel Get al., 2013, Subversion of trafficking, apoptosis, and innate immunity by type III secretion system effectors, TRENDS IN MICROBIOLOGY, Vol: 21, Pages: 430-439, ISSN: 0966-842X

JOURNAL ARTICLE

Tweedy L, Meier B, Stephan J, Heinrich D, Endres RGet al., 2013, Distinct cell shapes determine accurate chemotaxis, SCIENTIFIC REPORTS, Vol: 3, ISSN: 2045-2322

JOURNAL ARTICLE

Dart AE, Tollis S, Bright MD, Frankel G, Endres RGet al., 2012, The motor protein myosin 1G functions in Fc gamma R-mediated phagocytosis, JOURNAL OF CELL SCIENCE, Vol: 125, Pages: 6020-6029, ISSN: 0021-9533

JOURNAL ARTICLE

Endres RG, 2012, Intracellular chemical gradients: morphing principle in bacteria, BMC BIOPHYSICS, Vol: 5, ISSN: 2046-1682

JOURNAL ARTICLE

Endres RG, 2012, Signaling Crosstalk: New Insights Require New Vocabulary, BIOPHYSICAL JOURNAL, Vol: 103, Pages: 2241-2242, ISSN: 0006-3495

JOURNAL ARTICLE

Kalaji R, Wheeler AP, Erasmus JC, Lee SY, Endres RG, Cramer LP, Braga VMMet al., 2012, ROCK1 and ROCK2 regulate epithelial polarisation and geometric cell shape, BIOLOGY OF THE CELL, Vol: 104, Pages: 435-451, ISSN: 0248-4900

JOURNAL ARTICLE

Aquino G, Clausznitzer D, Tollis S, Endres RGet al., 2011, Optimal receptor-cluster size determined by intrinsic and extrinsic noise, PHYSICAL REVIEW E, Vol: 83, ISSN: 1539-3755

JOURNAL ARTICLE

Clausznitzer D, Endres RG, 2011, Noise characteristics of the Escherichia coli rotary motor, BMC SYSTEMS BIOLOGY, Vol: 5, ISSN: 1752-0509

JOURNAL ARTICLE

Aquino G, Endres RG, 2010, Increased accuracy of ligand sensing by receptor internalization, PHYSICAL REVIEW E, Vol: 81, ISSN: 1539-3755

JOURNAL ARTICLE

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