Imperial College London
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ProfessorRobertEndres

Faculty of Natural Sciences, Department of Life Sciences

Professor of Systems Biology
 
 
 
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Contact

 

+44 (0)20 7594 9537r.endres Website

 
 
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Location

 

315Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ojkic:2016:10.7554/eLife.18657,
author = {Ojkic, N and Lopez-Garrido, J and Pogliano, K and Endres, RG},
doi = {10.7554/eLife.18657},
journal = {eLife},
title = {Cell-wall remodeling drives engulfment during Bacillus subtiliss porulation},
url = {http://dx.doi.org/10.7554/eLife.18657},
volume = {5},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - When starved, the Gram-positive bacterium Bacillus subtilis forms durable spores forsurvival. Sporulation initiates with an asymmetric cell division, creating a large mother cell and asmall forespore. Subsequently, the mother cell membrane engulfs the forespore in a phagocytosislikeprocess. However, the force generation mechanism for forward membrane movement remainsunknown. Here, we show that membrane migration is driven by cell wall remodeling at the leadingedge of the engulfing membrane, with peptidoglycan synthesis and degradation mediated bypenicillin binding proteins in the forespore and a cell wall degradation protein complex in themother cell. We propose a simple model for engulfment in which the junction between the septumand the lateral cell wall moves around the forespore by a mechanism resembling the ‘templatemodel’. Hence, we establish a biophysical mechanism for the creation of a force for engulfmentbased on the coordination between cell wall synthesis and degradation.
AU  - Ojkic,N
AU  - Lopez-Garrido,J
AU  - Pogliano,K
AU  - Endres,RG
DO  - 10.7554/eLife.18657
PY  - 2016///
SN  - 2050-084X
TI  - Cell-wall remodeling drives engulfment during Bacillus subtiliss porulation
T2  - eLife
UR  - http://dx.doi.org/10.7554/eLife.18657
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000391440500001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/49406
VL  - 5
ER  -
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