Publications
425 results found
Li G, van Batenburg-Sherwood J, Safa BN, et al., 2023, Aging and intraocular pressure homeostasis in mice., bioRxiv
Age and elevated intraocular pressure (IOP) are the two primary risk factors for glaucoma, an optic neuropathy that is the leading cause of irreversible blindness. In most people, IOP is tightly regulated over a lifetime by the conventional outflow tissues. However, the mechanistic contributions of age to conventional outflow dysregulation, elevated IOP and glaucoma are unknown. To address this gap in knowledge, we studied how age affects the morphology, biomechanical properties and function of conventional outflow tissues in C57BL/6 mice, which have an outflow system similar to humans. As reported in humans, we observed that IOP in mice was maintained within a tight range over their lifespan. Remarkably, despite a constellation of age-related changes to the conventional outflow tissues that would be expected to hinder aqueous drainage and impair homeostatic function (decreased cellularity, increased pigment accumulation, increased cellular senescence and increased stiffness), outflow facility, a measure of conventional outflow tissue fluid conductivity, was stable with age. We conclude that the murine conventional outflow system has significant functional reserve in healthy eyes. However, these age-related changes, when combined with other underlying factors, such as genetic susceptibility, are expected to increase risk for ocular hypertension and glaucoma.
Bahrani Fard MR, Chan J, Sanchez Rodriguez G, et al., 2023, Improved magnetic delivery of cells to the trabecular meshwork in mice., Exp Eye Res, Vol: 234
Glaucoma is the leading cause of irreversible blindness worldwide and its most prevalent subtype is primary open angle glaucoma (POAG). One pathological change in POAG is loss of cells in the trabecular meshwork (TM), which is thought to contribute to ocular hypertension and has thus motivated development of cell-based therapies to refunctionalize the TM. TM cell therapy has shown promise in intraocular pressure (IOP) control, but existing cell delivery techniques suffer from poor delivery efficiency. We employed a novel magnetic delivery technique to reduce the unwanted side effects of off-target cell delivery. Mesenchymal stem cells (MSCs) were labeled with superparamagnetic iron oxide nanoparticles (SPIONs) and after intracameral injection were magnetically steered towards the TM using a focused magnetic apparatus ("point magnet"). This technique delivered the cells significantly closer to the TM at higher quantities and with more circumferential uniformity compared to either unlabeled cells or those delivered using a "ring magnet" technique. We conclude that our point magnet cell delivery technique can improve the efficiency of TM cell therapy and in doing so, potentially increase the therapeutic benefits and lower the risk of complications such as tumorigenicity and immunogenicity.
Ethier CR, Nguyen TV, 2023, Annual Special Issue: Journal of Biomechanical Engineering-2022 in Review, JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, Vol: 145, ISSN: 0148-0731
Nguyen TV, Ethier CR, 2023, The 2021 Richard Skalak Award and the 2021 Editors' Choice Papers, JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, Vol: 145, ISSN: 0148-0731
Brown DM, Yu J, Kumar P, et al., 2023, Exogenous All-Trans Retinoic Acid Induces Myopia and Alters Scleral Biomechanics in Mice, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 64, ISSN: 0146-0404
Safa BN, Read AT, Ethier CR, 2023, Assessment of the Viscoelastic Mechanical Properties of the Porcine Optic Nerve Head using Micromechanical Testing and Finite Element Modeling (vol 134, pg 379, 2021), ACTA BIOMATERIALIA, Vol: 161, ISSN: 1742-7061
Goyal V, Read AT, Brown DM, et al., 2023, Morphometric Analysis of Retinal Ganglion Cell Axons in Normal and Glaucomatous Brown Norway Rats Optic Nerves, TRANSLATIONAL VISION SCIENCE & TECHNOLOGY, Vol: 12, ISSN: 2164-2591
Goyal V, Read AT, Ritch MD, et al., 2023, AxoNet 2.0: A Deep Learning-Based Tool for Morphometric Analysis of Retinal Ganglion Cell Axons, TRANSLATIONAL VISION SCIENCE & TECHNOLOGY, Vol: 12, ISSN: 2164-2591
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- Citations: 1
Safa BN, Bleeker A, Berdahl JP, et al., 2023, The Effects of Negative Periocular Pressure on Biomechanics of the Optic Nerve Head and Cornea: A Computational Modeling Study, TRANSLATIONAL VISION SCIENCE & TECHNOLOGY, Vol: 12, ISSN: 2164-2591
Brown DM, Kowalski MA, Paulus QM, et al., 2022, Altered Structure and Function of Murine Sclera in Form-Deprivation Myopia, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 63, ISSN: 0146-0404
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- Citations: 4
Safa BN, Bahrani Fard MR, Ethier CR, 2022, <i>In vivo</i> biomechanical assessment of iridial deformations and muscle contractions in human eyes (vol 19, 20220108, 2022), JOURNAL OF THE ROYAL SOCIETY INTERFACE, Vol: 19, ISSN: 1742-5689
Coulon SJ, Schuman JS, Du Y, et al., 2022, A novel glaucoma approach: Stem cell regeneration of the trabecular meshwork, PROGRESS IN RETINAL AND EYE RESEARCH, Vol: 90, ISSN: 1350-9462
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- Citations: 6
Safa BN, Bahrani Fard MR, Ethier CR, 2022, <i>In vivo</i> biomechanical assessment of iridial deformations and muscle contractions in human eyes, JOURNAL OF THE ROYAL SOCIETY INTERFACE, Vol: 19, ISSN: 1742-5689
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- Citations: 1
Ethier CR, Nguyen TV, 2022, ANNUAL SPECIAL ISSUE: Journal of Biomechanical Engineering-Year(s) in Review, JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, Vol: 144, ISSN: 0148-0731
Brown D, Kowalski M, Paulus Q, et al., 2022, Form deprivation (FD) and exogenous all-trans retinoic acid (atRA) result in similar myopigenesis and scleral phenotypes in mice, Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, ISSN: 0146-0404
Safa B, Berdahl J, Ethier CR, 2022, The Effects of Negative Periocular Pressure on Biomechanics of the Optic Nerve Head (ONH) and Cornea: A Computational Modeling Study, Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, ISSN: 0146-0404
Ethier CR, Fard MRB, Safa B, 2022, A Novel Image-Based Method to Determine Iris Biomechanics in Angle-Closure Glaucoma, Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, ISSN: 0146-0404
Gerberich BG, Hannon BG, Brown DM, et al., 2022, Evaluation of Spatially Targeted Scleral Stiffening on Neuroprotection in a Rat Model of Glaucoma, TRANSLATIONAL VISION SCIENCE & TECHNOLOGY, Vol: 11, ISSN: 2164-2591
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- Citations: 3
Feola AJ, Girkin CA, Ethier CR, et al., 2022, A Potential Role of Acute Choroidal Expansion in Nonarteritic Anterior Ischemic Optic Neuropathy, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 63, ISSN: 0146-0404
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- Citations: 1
Safa BN, Read AT, Ethier CR, 2022, Assessment of the viscoelastic mechanical properties of the porcine optic nerve head using micromechanical testing and finite element modeling (vol 134, pg 379, 2021), ACTA BIOMATERIALIA, Vol: 141, Pages: 481-483, ISSN: 1742-7061
Safa BN, Wong CA, Ha J, et al., 2022, Glaucoma and biomechanics, CURRENT OPINION IN OPHTHALMOLOGY, Vol: 33, Pages: 80-90, ISSN: 1040-8738
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- Citations: 11
McDowell CM, Kizhatil K, Elliott MH, et al., 2022, Consensus recommendation for mouse models of ocular hypertension to study aqueous humor outflow and its mechanisms, Investigative Ophthalmology and Visual Science, Vol: 63, ISSN: 0146-0404
Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature of conventional outflow homeostasis and dysfunction that results in ocular hypertension. In this review, we describe a set of minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. We expect that this set of standard practices will increase scientific rigor when using mouse models and will better enable researchers to replicate and build upon previous findings.
Chan D, Won GJ, Read AT, et al., 2022, Application of an organotypic ocular perfusion model to assess intravitreal drug distribution in human and animal eyes, JOURNAL OF THE ROYAL SOCIETY INTERFACE, Vol: 19, ISSN: 1742-5689
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- Citations: 1
Jasien J, Read AT, Van Batenburg-Sherwood J, et al., 2022, Correspondence: Brian C. Samuels, ; bsamuels@uab.edu. PURPOSE. both model anatomy, anatomy purpose, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 63, ISSN: 0146-0404
Allen RS, Motz CT, Singh A, et al., 2021, Dependence of visual and cognitive outcomes on animal holder configuration in a rodent model of blast overpressure exposure, VISION RESEARCH, Vol: 188, Pages: 162-173, ISSN: 0042-6989
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- Citations: 3
Safa BN, Read AT, Ethier CR, 2021, Assessment of the viscoelastic mechanical properties of the porcine optic nerve head using micromechanical testing and finite element modeling, ACTA BIOMATERIALIA, Vol: 134, Pages: 379-387, ISSN: 1742-7061
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- Citations: 13
Hannon BG, Feola AJ, Gerberich BG, et al., 2021, Using retinal function to define ischemic exclusion criteria for animal models of glaucoma (vol 202, 108354, 2021), EXPERIMENTAL EYE RESEARCH, Vol: 210, ISSN: 0014-4835
Sater SH, Sass AM, Rohr JJ, et al., 2021, Automated MRI-based quantification of posterior ocular globe flattening and recovery after long-duration spaceflight, EYE, Vol: 35, Pages: 1869-1878, ISSN: 0950-222X
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- Citations: 7
Ethier CR, Goyal V, Sanchez-Rodriguez G, et al., 2021, Deep learning (DL)-based morphometric analysis of retinal ganglion cell (RGC) axons in a rat model of glaucoma, Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, ISSN: 0146-0404
Dattilo M, Brown D, Ethier CR, 2021, Comparison of Optic Nerve Sheath Material Properties in male and female rhesus macaque, Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, ISSN: 0146-0404
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