Imperial College London

Professor C. Ross Ethier

Faculty of EngineeringDepartment of Bioengineering

Visiting Professor
 
 
 
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Contact

 

r.ethier

 
 
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Location

 

Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

425 results found

Li G, van Batenburg-Sherwood J, Safa BN, Fraticelli Guzmán NS, Wilson A, Bahrani Fard MR, Choy K, De Ieso ML, Cui JS, Feola AJ, Weisz T, Kuhn M, Rickman CB, Farsiu S, Ethier CR, Stamer WDet al., 2023, Aging and intraocular pressure homeostasis in mice., bioRxiv

Age and elevated intraocular pressure (IOP) are the two primary risk factors for glaucoma, an optic neuropathy that is the leading cause of irreversible blindness. In most people, IOP is tightly regulated over a lifetime by the conventional outflow tissues. However, the mechanistic contributions of age to conventional outflow dysregulation, elevated IOP and glaucoma are unknown. To address this gap in knowledge, we studied how age affects the morphology, biomechanical properties and function of conventional outflow tissues in C57BL/6 mice, which have an outflow system similar to humans. As reported in humans, we observed that IOP in mice was maintained within a tight range over their lifespan. Remarkably, despite a constellation of age-related changes to the conventional outflow tissues that would be expected to hinder aqueous drainage and impair homeostatic function (decreased cellularity, increased pigment accumulation, increased cellular senescence and increased stiffness), outflow facility, a measure of conventional outflow tissue fluid conductivity, was stable with age. We conclude that the murine conventional outflow system has significant functional reserve in healthy eyes. However, these age-related changes, when combined with other underlying factors, such as genetic susceptibility, are expected to increase risk for ocular hypertension and glaucoma.

Journal article

Bahrani Fard MR, Chan J, Sanchez Rodriguez G, Yonk M, Kuturu SR, Read AT, Emelianov SY, Kuehn MH, Ethier CRet al., 2023, Improved magnetic delivery of cells to the trabecular meshwork in mice., Exp Eye Res, Vol: 234

Glaucoma is the leading cause of irreversible blindness worldwide and its most prevalent subtype is primary open angle glaucoma (POAG). One pathological change in POAG is loss of cells in the trabecular meshwork (TM), which is thought to contribute to ocular hypertension and has thus motivated development of cell-based therapies to refunctionalize the TM. TM cell therapy has shown promise in intraocular pressure (IOP) control, but existing cell delivery techniques suffer from poor delivery efficiency. We employed a novel magnetic delivery technique to reduce the unwanted side effects of off-target cell delivery. Mesenchymal stem cells (MSCs) were labeled with superparamagnetic iron oxide nanoparticles (SPIONs) and after intracameral injection were magnetically steered towards the TM using a focused magnetic apparatus ("point magnet"). This technique delivered the cells significantly closer to the TM at higher quantities and with more circumferential uniformity compared to either unlabeled cells or those delivered using a "ring magnet" technique. We conclude that our point magnet cell delivery technique can improve the efficiency of TM cell therapy and in doing so, potentially increase the therapeutic benefits and lower the risk of complications such as tumorigenicity and immunogenicity.

Journal article

Ethier CR, Nguyen TV, 2023, Annual Special Issue: Journal of Biomechanical Engineering-2022 in Review, JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, Vol: 145, ISSN: 0148-0731

Journal article

Nguyen TV, Ethier CR, 2023, The 2021 Richard Skalak Award and the 2021 Editors' Choice Papers, JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, Vol: 145, ISSN: 0148-0731

Journal article

Brown DM, Yu J, Kumar P, Paulus QM, Kowalski MA, Patel JM, Kane MA, Ethier CR, Pardue MTet al., 2023, Exogenous All-Trans Retinoic Acid Induces Myopia and Alters Scleral Biomechanics in Mice, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 64, ISSN: 0146-0404

Journal article

Goyal V, Read AT, Brown DM, Brawer L, Bateh K, Hannon BG, Feola AJ, Ethier CRet al., 2023, Morphometric Analysis of Retinal Ganglion Cell Axons in Normal and Glaucomatous Brown Norway Rats Optic Nerves, TRANSLATIONAL VISION SCIENCE & TECHNOLOGY, Vol: 12, ISSN: 2164-2591

Journal article

Goyal V, Read AT, Ritch MD, Hannon BG, Rodriguez GS, Brown DM, Feola AJ, Hedberg-Buenz A, Cull GA, Reynaud J, Garvin MK, Anderson MG, Burgoyne CF, Ethier CRet al., 2023, AxoNet 2.0: A Deep Learning-Based Tool for Morphometric Analysis of Retinal Ganglion Cell Axons, TRANSLATIONAL VISION SCIENCE & TECHNOLOGY, Vol: 12, ISSN: 2164-2591

Journal article

Safa BN, Bleeker A, Berdahl JP, Ethier CRet al., 2023, The Effects of Negative Periocular Pressure on Biomechanics of the Optic Nerve Head and Cornea: A Computational Modeling Study, TRANSLATIONAL VISION SCIENCE & TECHNOLOGY, Vol: 12, ISSN: 2164-2591

Journal article

Brown DM, Kowalski MA, Paulus QM, Yu J, Kumar P, Kane MA, Patel JM, Ethier CR, Pardue MTet al., 2022, Altered Structure and Function of Murine Sclera in Form-Deprivation Myopia, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 63, ISSN: 0146-0404

Journal article

Safa BN, Bahrani Fard MR, Ethier CR, 2022, <i>In vivo</i> biomechanical assessment of iridial deformations and muscle contractions in human eyes (vol 19, 20220108, 2022), JOURNAL OF THE ROYAL SOCIETY INTERFACE, Vol: 19, ISSN: 1742-5689

Journal article

Coulon SJ, Schuman JS, Du Y, Fard MRB, Ethier CR, Stamer WDet al., 2022, A novel glaucoma approach: Stem cell regeneration of the trabecular meshwork, PROGRESS IN RETINAL AND EYE RESEARCH, Vol: 90, ISSN: 1350-9462

Journal article

Safa BN, Bahrani Fard MR, Ethier CR, 2022, <i>In vivo</i> biomechanical assessment of iridial deformations and muscle contractions in human eyes, JOURNAL OF THE ROYAL SOCIETY INTERFACE, Vol: 19, ISSN: 1742-5689

Journal article

Ethier CR, Nguyen TV, 2022, ANNUAL SPECIAL ISSUE: Journal of Biomechanical Engineering-Year(s) in Review, JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, Vol: 144, ISSN: 0148-0731

Journal article

Brown D, Kowalski M, Paulus Q, Yu J, Kumar P, Kane MA, Patel J, Ethier CR, Pardue MTet al., 2022, Form deprivation (FD) and exogenous all-trans retinoic acid (atRA) result in similar myopigenesis and scleral phenotypes in mice, Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, ISSN: 0146-0404

Conference paper

Safa B, Berdahl J, Ethier CR, 2022, The Effects of Negative Periocular Pressure on Biomechanics of the Optic Nerve Head (ONH) and Cornea: A Computational Modeling Study, Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, ISSN: 0146-0404

Conference paper

Ethier CR, Fard MRB, Safa B, 2022, A Novel Image-Based Method to Determine Iris Biomechanics in Angle-Closure Glaucoma, Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, ISSN: 0146-0404

Conference paper

Gerberich BG, Hannon BG, Brown DM, Read AT, Ritch MD, Echeverri ES, Nichols L, Potnis C, Sridhar S, Toothman MG, Schwaner SA, Winger EJ, Huang H, Gershon GS, Feola AJ, Pardue MT, Prausnitz MR, Ethier CRet al., 2022, Evaluation of Spatially Targeted Scleral Stiffening on Neuroprotection in a Rat Model of Glaucoma, TRANSLATIONAL VISION SCIENCE & TECHNOLOGY, Vol: 11, ISSN: 2164-2591

Journal article

Feola AJ, Girkin CA, Ethier CR, Samuels BCet al., 2022, A Potential Role of Acute Choroidal Expansion in Nonarteritic Anterior Ischemic Optic Neuropathy, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 63, ISSN: 0146-0404

Journal article

Safa BN, Wong CA, Ha J, Ethier CRet al., 2022, Glaucoma and biomechanics, CURRENT OPINION IN OPHTHALMOLOGY, Vol: 33, Pages: 80-90, ISSN: 1040-8738

Journal article

McDowell CM, Kizhatil K, Elliott MH, Overby DR, Van Batenburg-Sherwood J, Millar JC, Kuehn MH, Zode G, Acott TS, Anderson MG, Bhattacharya SK, Bertrand JA, Borras T, Bovenkamp DE, Cheng L, Danias J, De Ieso ML, Du Y, Faralli JA, Fuchshofer R, Ganapathy PS, Gong H, Herberg S, Hernandez H, Humphries P, John SWM, Kaufman PL, Keller KE, Kelley MJ, Kelly RA, Krizaj D, Kumar A, Leonard BC, Lieberman RL, Liton P, Liu Y, Liu KC, Lopez NN, Mao W, Mavlyutov T, McDonnell F, McLellan GJ, Mzyk P, Nartey A, Pasquale LR, Patel GC, Pattabiraman PP, Peters DM, Raghunathan V, Rao PV, Rayana N, Raychaudhuri U, Reina-Torres E, Ren R, Rhee D, Chowdhury UR, Samples JR, Samples EG, Sharif N, Schuman JS, Sheffield VC, Stevenson CH, Soundararajan A, Subramanian P, Sugali CK, Sun Y, Toris CB, Torrejon KY, Vahabikashi A, Vranka JA, Wang T, Willoughby CE, Xin C, Yun H, Zhang HF, Fautsch MP, Tamm ER, Clark AF, Ethier CR, Stamer WDet al., 2022, Consensus recommendation for mouse models of ocular hypertension to study aqueous humor outflow and its mechanisms, Investigative Ophthalmology and Visual Science, Vol: 63, ISSN: 0146-0404

Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature of conventional outflow homeostasis and dysfunction that results in ocular hypertension. In this review, we describe a set of minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. We expect that this set of standard practices will increase scientific rigor when using mouse models and will better enable researchers to replicate and build upon previous findings.

Journal article

Chan D, Won GJ, Read AT, Ethier CR, Thackaberry E, Crowell SR, Booler H, Bantseev V, Sivak JMet al., 2022, Application of an organotypic ocular perfusion model to assess intravitreal drug distribution in human and animal eyes, JOURNAL OF THE ROYAL SOCIETY INTERFACE, Vol: 19, ISSN: 1742-5689

Journal article

Jasien J, Read AT, Van Batenburg-Sherwood J, Perkumas KM, Ethier CR, Stamer WD, Samuels BCet al., 2022, Correspondence: Brian C. Samuels, ; bsamuels@uab.edu. PURPOSE. both model anatomy, anatomy purpose, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 63, ISSN: 0146-0404

Journal article

Allen RS, Motz CT, Singh A, Feola A, Hutson L, Douglass A, Rao SR, Skelton LA, Cardelle L, Bales KL, Chesler K, Gudapati K, Ethier CR, Harper MM, Fliesler SJ, Pardue MTet al., 2021, Dependence of visual and cognitive outcomes on animal holder configuration in a rodent model of blast overpressure exposure, VISION RESEARCH, Vol: 188, Pages: 162-173, ISSN: 0042-6989

Journal article

Safa BN, Read AT, Ethier CR, 2021, Assessment of the viscoelastic mechanical properties of the porcine optic nerve head using micromechanical testing and finite element modeling, ACTA BIOMATERIALIA, Vol: 134, Pages: 379-387, ISSN: 1742-7061

Journal article

Hannon BG, Feola AJ, Gerberich BG, Read AT, Prausnitz MR, Ethier CR, Pardue MTet al., 2021, Using retinal function to define ischemic exclusion criteria for animal models of glaucoma (vol 202, 108354, 2021), EXPERIMENTAL EYE RESEARCH, Vol: 210, ISSN: 0014-4835

Journal article

Sater SH, Sass AM, Rohr JJ, Marshall-Goebel K, Ploutz-Snyder RJ, Ethier CR, Stenger MB, Kramer LA, Martin BA, Macias BRet al., 2021, Automated MRI-based quantification of posterior ocular globe flattening and recovery after long-duration spaceflight, EYE, Vol: 35, Pages: 1869-1878, ISSN: 0950-222X

Journal article

Ethier CR, Goyal V, Sanchez-Rodriguez G, Brown D, Hannon B, Toporek AM, Ritch MD, Feola A, Read ATet al., 2021, Deep learning (DL)-based morphometric analysis of retinal ganglion cell (RGC) axons in a rat model of glaucoma, Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, ISSN: 0146-0404

Conference paper

Dattilo M, Brown D, Ethier CR, 2021, Comparison of Optic Nerve Sheath Material Properties in male and female rhesus macaque, Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, ISSN: 0146-0404

Conference paper

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