Imperial College London

DrRolfHeckemann

Faculty of MedicineDepartment of Medicine

Honorary Research Fellow
 
 
 
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Contact

 

+44 (0)20 8816 7653r.heckemann Website

 
 
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Location

 

Cyclotron buildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

97 results found

Andersson KME, Wasen C, Juzokaite L, Leifsdottir L, Erlandsson MC, Silfversward ST, Stokowska A, Pekna M, Pekny M, Olmarker K, Heckemann RA, Kalm M, Bokarewa MIet al., 2018, Inflammation in the hippocampus affects IGF1 receptor signaling and contributes to neurological sequelae in rheumatoid arthritis, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 115, Pages: E12063-E12072, ISSN: 0027-8424

JOURNAL ARTICLE

Prange S, Metereau E, Maillet A, Lhommee E, Klinger H, Pelissier P, Ibarrola D, Heckemann RA, Broussolle E, Castrioto A, Tremblay L, Sgambato V, Krack P, Thobois Set al., 2018, Microstructural changes in white and grey matter related to apathy, depression and anxiety in de novo Parkinson's disease patients, International Congress of Parkinson's Disease and Movement Disorders, Publisher: WILEY, Pages: S674-S674, ISSN: 0885-3185

CONFERENCE PAPER

Ledig C, Schuh A, Guerrero R, Heckemann RA, Rueckert Det al., 2018, Structural brain imaging in Alzheimer's disease and mild cognitive impairment: biomarker analysis and shared morphometry database, SCIENTIFIC REPORTS, Vol: 8, ISSN: 2045-2322

JOURNAL ARTICLE

Andersson KM, Wasen C, Silfversward ST, Leifsdottir L, Erlandsson MC, Heckemann RA, Kalm M, Bokarewa MIet al., 2018, Physical functioning in rheumatoid arthritis is controlled by hippocampus and insulin-like growth factor-1 receptor signalling, Publisher: TAYLOR & FRANCIS LTD, Pages: 28-28, ISSN: 0300-9742

CONFERENCE PAPER

Wild HM, Heckemann RA, Studholme C, Hammers Aet al., 2017, Gyri of the human parietal lobe: Volumes, spatial extents, automatic labelling, and probabilistic atlases, PLOS ONE, Vol: 12, ISSN: 1932-6203

JOURNAL ARTICLE

Faillenot I, Heckemann RA, Frot M, Hammers Aet al., 2017, Macroanatomy and 3D probabilistic atlas of the human insula., Neuroimage, Vol: 150, Pages: 88-98

The human insula is implicated in numerous functions. More and more neuroimaging studies focus on this region, however no atlas offers a complete subdivision of the insula in a reference space. The aims of this study were to define a protocol to subdivide insula, to create probability maps in the MNI152 stereotaxic space, and to provide normative reference volume measurements for these subdivisions. Six regions were manually delineated bilaterally on 3D T1 MR images of 30 healthy subjects: the three short gyri, the anterior inferior cortex, and the two long gyri. The volume of the insular grey matter was 7.7 ± 0.9cm3 in native space and 9.9 ± 0.6cm3 in MNI152 space. These volumes expressed as a percentage of the ipsilateral grey matter volume were minimally larger in women (2.7±0.2%) than in men (2.6±0.2%). After spatial normalization, a stereotactic probabilistic atlas of each subregion was produced, as well as a maximum-probability atlas taking into account surrounding structures. Automatically labelling insular subregions via a multi-atlas propagation and label fusion strategy (MAPER) in a leave-one-out experiment showed high spatial overlaps of such automatically defined insular subregions with the manually derived ones (mean Jaccard index 0.65, corresponding to a mean Dice index of 0.79), with an average mean volume error of 2.6%. Probabilistic and maximum probability atlases and the original delineations are available on the web under free academic licences.

JOURNAL ARTICLE

Merida I, Reilhac A, Redoute J, Heckemann RA, Costes N, Hammers Aet al., 2017, Multi-atlas attenuation correction supports full quantification of static and dynamic brain PET data in PET-MR, PHYSICS IN MEDICINE AND BIOLOGY, Vol: 62, Pages: 2834-2858, ISSN: 0031-9155

JOURNAL ARTICLE

Rosen J, Krysl D, Strandberg J, Rydenhag B, Malmgren K, Heckemann RAet al., 2016, THREE-DIMENSIONAL VISUALIZATION OF MORPHOMETRIC BRAIN ANOMALIES IN PATIENTS WITH TEMPORAL LOBE EPILEPSY, Publisher: WILEY, Pages: 224-224, ISSN: 0013-9580

CONFERENCE PAPER

Scott G, Ramlackhansingh AF, Edison P, Hellyer P, Cole J, Veronese M, Leech R, Greenwood RJ, Turkheimer FE, Gentleman SM, Heckemann RA, Matthews PM, Brooks DJ, Sharp DJet al., 2016, Amyloid pathology and axonal injury after brain trauma, NEUROLOGY, Vol: 86, Pages: 821-828, ISSN: 0028-3878

JOURNAL ARTICLE

Sapey-Triomphe L-A, Heckemann RA, Boublay N, Dorey J-M, Henaff M-A, Rouch I, Padovan C, Hammers A, Krolak-Salmon Pet al., 2015, Neuroanatomical Correlates of Recognizing Face Expressions in Mild Stages of Alzheimer's Disease, PLOS ONE, Vol: 10, ISSN: 1932-6203

JOURNAL ARTICLE

Heckemann RA, Ledig C, Gray KR, Aljabar P, Rueckert D, Hajnal JV, Hammers Aet al., 2015, Brain Extraction Using Label Propagation and Group Agreement: Pincram (vol 10, e0129211, 2015), PLOS ONE, Vol: 10, ISSN: 1932-6203

JOURNAL ARTICLE

Heckemann RA, Ledig C, Gray KR, Aljabar P, Rueckert D, Hajnal JV, Hammers Aet al., 2015, Brain Extraction Using Label Propagation and Group Agreement: Pincram, PLOS ONE, Vol: 10, ISSN: 1932-6203

JOURNAL ARTICLE

Ledig C, Heckemann RA, Hammers A, Lopez JC, Newcombe VFJ, Makropoulos A, Loetjoenen J, Menon DK, Rueckert Det al., 2015, Robust whole-brain segmentation: Application to traumatic brain injury, MEDICAL IMAGE ANALYSIS, Vol: 21, Pages: 40-58, ISSN: 1361-8415

JOURNAL ARTICLE

Merida I, Costes N, Heckemann RA, Drzezga A, Forster S, Hammers Aet al., 2015, EVALUATION OF SEVERAL MULTI-ATLAS METHODS FOR PSEUDO-CT GENERATION IN BRAIN MRI-PET ATTENUATION CORRECTION, IEEE 12th International Symposium on Biomedical Imaging, Publisher: IEEE, Pages: 1431-1434, ISSN: 1945-7928

CONFERENCE PAPER

Ramdeen KT, Heckemann RA, Hammers A, Klein-Koerkamp Y, Moreaud O, Keignart S, Krainik A, Richard-Mornas A, Hot Pet al., 2014, Amygdalar Atrophy as a Predictor of Cognitive Decline in Mild Cognitive Impairment, Publisher: CANADIAN PSYCHOLOGICAL ASSOC, Pages: 258-258, ISSN: 1196-1961

CONFERENCE PAPER

Barros DAR, McGinnity CJ, Rosso L, Heckemann RA, Howes OD, Brooks DJ, Duncan JS, Turkheimer FE, Koepp MJ, Hammers Aet al., 2014, Test-retest reproducibility of cannabinoid-receptor type 1 availability quantified with the PET ligand [C-11]MePPEP, NEUROIMAGE, Vol: 97, Pages: 151-162, ISSN: 1053-8119

JOURNAL ARTICLE

Hammers A, Barros RDA, McGinnity CJ, Rosso LA, Heckemann RA, Egerton A, Bhattacharyya S, Howes OD, Brooks DJ, Duncan JS, Turkheimer FE, Koepp MJet al., 2014, CANNABINOID RECEPTOR TYPE 1 AVAILABILITY AND SPONTANEOUS TEMPORAL LOBE SEIZURES, 11th European Congress on Epileptology, Publisher: WILEY-BLACKWELL, Pages: 223-223, ISSN: 0013-9580

CONFERENCE PAPER

Rizzo G, Veronese M, Heckemann RA, Selvaraj S, Howes OD, Hammers A, Turkheimer FE, Bertoldo Aet al., 2014, The predictive power of brain mRNA mappings for in vivo protein density: a positron emission tomography correlation study, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol: 34, Pages: 827-835, ISSN: 0271-678X

JOURNAL ARTICLE

Ciumas C, Saignavongs M, Ilski F, Herbillon V, Laurent A, Lothe A, Heckemann RA, Bellescize JD, Panagiotakaki E, Hannoun S, Marinier DS, Montavont A, Ostrowsky-Coste K, Bedoin N, Ryvlin Pet al., 2014, White matter development in children with benign childhood epilepsy with centro-temporal spikes, Joint Congress of European Neurology, Publisher: SPRINGER HEIDELBERG, Pages: S45-S45, ISSN: 0340-5354

CONFERENCE PAPER

Ciumas C, Saignavongs M, Ilski F, Herbillon V, Laurent A, Lothe A, Heckemann RA, Bellescize JD, Panagiotakaki E, Hannoun S, Marinier DS, Montavont A, Ostrowsky-Coste K, Bedoin N, Ryvlin Pet al., 2014, White matter development in children with benign childhood epilepsy with centro-temporal spikes, Joint Congress of European Neurology, Publisher: WILEY-BLACKWELL, Pages: 60-60, ISSN: 1351-5101

CONFERENCE PAPER

Ciumas C, Saignavongs M, Ilski F, Herbillon V, Laurent A, Lothe A, Heckemann RA, de Bellescize J, Panagiotakaki E, Hannoun S, Marinier DS, Montavont A, Ostrowsky-Coste K, Bedoin N, Ryvlin Pet al., 2014, White matter development in children with benign childhood epilepsy with centro-temporal spikes, BRAIN, Vol: 137, Pages: 1095-1106, ISSN: 0006-8950

JOURNAL ARTICLE

Klein-Koerkamp Y, Heckemann RA, Ramdeen KT, Moreaud O, Keignart S, Krainik A, Hammers A, Baciu M, Hot Pet al., 2014, Amygdalar Atrophy in Early Alzheimer's Disease, CURRENT ALZHEIMER RESEARCH, Vol: 11, Pages: 239-252, ISSN: 1567-2050

JOURNAL ARTICLE

Ledig C, Shi W, Makropoulos A, Koikkalainen J, Heckemann RA, Hammers A, Lotjonen J, Tenovuo O, Rueckert Det al., 2014, CONSISTENT AND ROBUST 4D WHOLE-BRAIN SEGMENTATION: APPLICATION TO TRAUMATIC BRAIN INJURY, 11th IEEE International Symposium on Biomedical Imaging (ISBI), Publisher: IEEE, Pages: 673-676, ISSN: 1945-7928

CONFERENCE PAPER

Rubi S, Costes N, Heckemann RA, Bouvard S, Hammers A, Marti Fuster B, Ostrowsky K, Montavont A, Jung J, Setoain X, Catenoix H, Hino K, Liger F, Le Bars D, Ryvlin Pet al., 2013, Positron emission tomography with alpha-[C-11]methyl-L-tryptophan in tuberous sclerosis complex-related epilepsy, EPILEPSIA, Vol: 54, Pages: 2143-2150, ISSN: 0013-9580

JOURNAL ARTICLE

McGinnity CJ, Shidahara M, Feldmann M, Keihaninejad S, Barros DAR, Gousias IS, Duncan JS, Brooks DJ, Heckemann RA, Turkheimer FE, Hammers A, Koepp MJet al., 2013, Quantification of opioid receptor availability following spontaneous epileptic seizures: Correction of [C-11]diprenorphine PET data for the partial-volume effect, NEUROIMAGE, Vol: 79, Pages: 72-80, ISSN: 1053-8119

JOURNAL ARTICLE

Cross JH, Arora R, Heckemann RA, Gunny R, Chong K, Carr L, Baldeweg T, Differ A-M, Lench N, Varadkar S, Sirimanna T, Wassmer E, Hulton SA, Ognjanovic M, Ramesh V, Feather S, Kleta R, Hammers A, Bockenhauer Det al., 2013, Neurological features of epilepsy, ataxia, sensorineural deafness, tubulopathy syndrome, DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY, Vol: 55, Pages: 846-856, ISSN: 0012-1622

JOURNAL ARTICLE

Butler C, van Erp W, Bhaduri A, Hammers A, Heckemann R, Zeman Aet al., 2013, Magnetic resonance volumetry reveals focal brain atrophy in transient epileptic amnesia., Epilepsy Behav, Vol: 28, Pages: 363-369

Transient epileptic amnesia (TEA) is a recently described epilepsy syndrome characterized by recurrent episodes of isolated memory loss. It is associated with two unusual forms of interictal memory impairment: accelerated long-term forgetting (ALF) and autobiographical amnesia. We investigated the neural basis of TEA using manual volumetry and automated multi-atlas-based segmentation of whole-brain magnetic resonance imaging data from 40 patients with TEA and 20 healthy controls. Both methods confirmed the presence of subtle, bilateral hippocampal atrophy. Additional atrophy was revealed in perirhinal and orbitofrontal cortices. The volumes of these regions correlated with anterograde memory performance. No structural correlates were found for ALF or autobiographical amnesia. The results support the hypothesis that TEA is a focal medial temporal lobe epilepsy syndrome but reveal additional pathology in connected brain regions. The unusual interictal memory deficits of TEA remain unexplained by structural pathology and may reflect physiological disruption of memory networks by subclinical epileptiform activity.

JOURNAL ARTICLE

Ciumas C, Saignavongs M, Ilski F, Heckemann RA, Herbillon V, De Bellescize J, Panagiotakaki E, Hannoun S, Sappey-Marinier D, Ostrowsky-Coste K, Ryvlin Pet al., 2013, WHITE MATTER DEVELOPMENT IN CHILDREN WITH IDIOPATHIC LOCALIZATION-RELATED EPILEPSY, 30th International Epilepsy Congress, Publisher: WILEY-BLACKWELL, Pages: 237-237, ISSN: 0013-9580

CONFERENCE PAPER

Gousias IS, Hammers A, Counsell SJ, Srinivasan L, Rutherford MA, Heckemann RA, Hajnal JV, Rueckert D, Edwards ADet al., 2013, Magnetic Resonance Imaging of the Newborn Brain: Automatic Segmentation of Brain Images into 50 Anatomical Regions, PLOS ONE, Vol: 8, ISSN: 1932-6203

JOURNAL ARTICLE

Gray KR, Aljabar P, Heckemann R, Hammers A, Rueckert Det al., 2013, Manifold forests for multi-modality classification of Alzheimer's disease, Decision Forests for Computer Vision and Medical Image Analysis, Editors: Criminisi, Shotton, Publisher: Springer, ISBN: 9781447149286

The book concludes with a detailed discussion on the efficient implementation of decision forests. Topics and features: With a foreword by Prof. Yali Amit and Prof.

BOOK CHAPTER

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