Publications
520 results found
Newton SM, Mackie SL, Martineau AR, et al., 2008, Reduction of chemokine secretion in response to mycobacteria in infliximab-treated patients, CLINICAL AND VACCINE IMMUNOLOGY, Vol: 15, Pages: 506-512, ISSN: 1556-6811
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- Citations: 19
Martineau AR, Griffiths CJ, Wilkinson RJ, 2008, Vitamin D in the treatment and prevention of tuberculosis., Expert Rev Endocrinol Metab, Vol: 3, Pages: 105-107
Chege GK, Warren RM, Gey van Pittius NC, et al., 2008, Detection of natural infection with <i>Mycobacterium intracellulare</i> in healthy wild-caught Chacma baboons (<i>Papio ursinus</i>) by ESAT-6 and CFP-10IFN-γ ELISPOT tests following a tuberculosis outbreak, BMC MICROBIOLOGY, Vol: 8, ISSN: 1471-2180
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- Citations: 9
Scriba TJ, Kalsdorf B, Abrahams D-A, et al., 2008, Distinct, specific IL-17- and IL-22-producing CD4<SUP>+</SUP> T cell subsets contribute to the human anti-mycobacterial immune response, JOURNAL OF IMMUNOLOGY, Vol: 180, Pages: 1962-1970, ISSN: 0022-1767
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- Citations: 335
Dhasmana DJ, Dheda K, Ravn P, et al., 2008, Immune reconstitution inflammatory syndrome in HIV-Infected patients receiving Antiretroviral therapy - Pathogenesis, clinical manifestations and management, DRUGS, Vol: 68, Pages: 191-208, ISSN: 0012-6667
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- Citations: 118
Maartens G, Wilkinson RJ, 2007, Tuberculosis, LANCET, Vol: 370, Pages: 2030-2043, ISSN: 0140-6736
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- Citations: 237
Martineau AR, Wilkinson KA, Newton SM, et al., 2007, IFN-γ- and TNF-independent vitamin D-inducible human suppression of mycobacteria: The role of cathelicidin LL-37 (Journal of Immunology (2007) 178 (7190-7198)), Journal of Immunology, Vol: 179, Pages: 8569-8570, ISSN: 0022-1767
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- Citations: 2
Martineau AR, Wilkinson KA, Newton SM, et al., 2007, IFN-γ- and TNF-independent vitamin D-inducible human suppression of mycobacteria:: the role of cathelicidin LL-37 (vol 178, pg 7190, 2007), JOURNAL OF IMMUNOLOGY, Vol: 179, Pages: 8569-8570, ISSN: 0022-1767
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- Citations: 2
McIlleron H, Watkins ML, Folb PI, et al., 2007, Rifampin levels, interferon-gamma release and outcome in complicated pulmonary tuberculosis, TUBERCULOSIS, Vol: 87, Pages: 557-564, ISSN: 1472-9792
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- Citations: 13
Pepper DJ, Meintjes GA, Mcllleron H, et al., 2007, Combined therapy for tuberclosis and HIV-1: the challenge for drug discovery, DRUG DISCOVERY TODAY, Vol: 12, Pages: 980-989, ISSN: 1359-6446
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- Citations: 30
Henao-Tamayo M, Junqueira-Kipnis AP, Ordway D, et al., 2007, A mutant of <i>Mycobacterium tuberculosis</i> lacking the 19-kDa lipoprotein Rv3763 is highly attenuated <i>in vivo</i> but retains potent vaccinogenic properties, VACCINE, Vol: 25, Pages: 7153-7159, ISSN: 0264-410X
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- Citations: 20
Lawn SD, Bangani N, Vogt M, et al., 2007, Utility of interferon-γ ELISPOT assay responses in highly tuberculosis-exposed patients with advanced HIV infection in South Africa, BMC INFECTIOUS DISEASES, Vol: 7, ISSN: 1471-2334
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- Citations: 50
Martineau AR, Wilkinson RJ, Wilkinson KA, et al., 2007, A single dose of vitamin D enhances immunity to mycobacteria, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 176, Pages: 208-213, ISSN: 1073-449X
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- Citations: 312
Connell TG, Shey MS, Seldon R, et al., 2007, Enhanced ex vivo stimulation of <i>Mycobacterium tuberculosis</i>-specific T cells in human immunodeficiency virus-infected persons via antigen delivery by the <i>Bordetella pertussis</i> adenylate cyclase vector, CLINICAL AND VACCINE IMMUNOLOGY, Vol: 14, Pages: 847-854, ISSN: 1556-6811
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- Citations: 12
Martineau AR, Newton SM, Wilkinson KA, et al., 2007, Neutrophil-mediated innate immune resistance to mycobacteria, JOURNAL OF CLINICAL INVESTIGATION, Vol: 117, Pages: 1988-1994, ISSN: 0021-9738
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- Citations: 280
Rangaka MX, Diwakar L, Seldon R, et al., 2007, Clinical, immunological, and epidemiological importance of antituberculosis T cell responses in HIV-infected Africans, CLINICAL INFECTIOUS DISEASES, Vol: 44, Pages: 1639-1646, ISSN: 1058-4838
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- Citations: 63
Martineau AR, Wilkinson KA, Newton SM, et al., 2007, IFN-γ- and TNF-independent vitamin D-inducible human suppression of mycobacteria: The role of cathelicidin LL-37, Journal of Immunology, Vol: 178, Pages: 7190-7198, ISSN: 0022-1767
Vitamin D deficiency is associated with susceptibility to tuberculosis, and its biologically active metabolite, 1α,25 dihydroxyvitamin D3 (1α,25(OH)2D3), has pleiotropic immune effects. The mechanisms by which 1α,25(OH)2D3 protects against tuberculosis are incompletely understood. 1α,25(OH)2D 3 reduced the growth of mycobacteria in infected human PBMC cultures in a dose-dependent fashion. Coculture with agonists or antagonists of the membrane or nuclear vitamin D receptors indicated that these effects were primarily mediated by the nuclear vitamin D receptors. 1α,25(OH) 2D3 reduced transcription and secretion of protective IFN-γ, IL-12p40, and TNF in infected PBMC and macrophages, indicating that 1α,25(OH)2D3 does not mediate protection via these cytokines. Although NOS2A was up-regulated by 1α,25(OH)2D 3, inhibition of NO formation marginally affected the suppressive effect of 1α,25(OH)2D3 on bacillus Calmette Guérin in infected cells. By contrast, 1α,25(OH)2D 3 strongly up-regulated the cathelicidin hCAP-18 gene, and some hCAP-18 polypeptide colocalized with CD14 in 1α,25(OH)2D 3 stimulated PBMC, although no detectable LL-37 peptide was found in supernatants from similar 1α,25(OH)2D3-stimulated PBMC cultures. A total of 200 μg/ml of the active peptide LL-37, in turn, reduced the growth of Mycobacterium tuberculosis in culture by 75.7%. These findings suggest that vitamin D contributes to protection against TB by "nonclassical" mechanisms that include the induction of antimicrobial peptides. Copyright © 2007 by The American Association of Immunologists, Inc.
Martineau AR, Wilkinson KA, Newton SM, et al., 2007, IFN-γ- and TNF-independent vitamin D-inducible human suppression of mycobacteria:: The role of cathelicidin LL-37, JOURNAL OF IMMUNOLOGY, Vol: 178, Pages: 7190-7198, ISSN: 0022-1767
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- Citations: 326
Nicol MP, Wilkinson RJ, 2007, Evidence guiding the treatment of children with mycobacterial diseases - Editorial commentary, CLINICAL INFECTIOUS DISEASES, Vol: 44, Pages: 1065-1066, ISSN: 1058-4838
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- Citations: 2
Rangaka MX, Wilkinson KA, Seldon R, et al., 2007, Effect of HIV-1 infection on T-cell-based and skin test detection of tuberculosis infection, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 175, Pages: 514-520, ISSN: 1073-449X
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- Citations: 179
Martineau AR, Honecker FU, Wilkinson RJ, et al., 2007, Vitamin D in the treatment of pulmonary tuberculosis, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, Vol: 103, Pages: 793-798, ISSN: 0960-0760
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- Citations: 175
Newton SM, Smith RJ, Wilkinson KA, et al., 2007, A deletion defining a common Asian lineage of <i>Mycobacterium tuberculosis</i> associates with immune subversion (vol 103, pg 15594, 2006), PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 104, Pages: 685-685, ISSN: 0027-8424
Speert DP, Quesniaux V, Latgé JP, et al., 2006, Discussion, Pages: 139-141, ISSN: 1528-2511
Hussell T, Lambrecht BN, Bateman E, et al., 2006, Discussion, Pages: 200-205, ISSN: 1528-2511
Segal A, Van Helden P, Quesniaux V, et al., 2006, Discussion, Pages: 31-41, ISSN: 1528-2511
Lawn SD, Wilkinson RJ, 2006, Immune reconstitution disease associated with parasitic infections following antiretroviral treatment, PARASITE IMMUNOLOGY, Vol: 28, Pages: 625-633, ISSN: 0141-9838
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- Citations: 46
Newton SM, Smith RJ, Wilkinson KA, et al., 2006, A deletion defining a common Asian lineage of <i>Mycobacterium tuberculosis</i> associates with immune subversion, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 103, Pages: 15594-15598, ISSN: 0027-8424
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- Citations: 84
Lawn SD, Wilkinson R, 2006, Extensively drug resistant tuberculosis - A serious wake-up call for global health, BRITISH MEDICAL JOURNAL, Vol: 333, Pages: 559-560, ISSN: 0959-8146
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- Citations: 41
Connell TG, Rangaka MX, Curtis N, et al., 2006, QuantiFERON-TB Gold: state of the art for the diagnosis of tuberculosis infection?, EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, Vol: 6, Pages: 663-677, ISSN: 1473-7159
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- Citations: 44
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