Imperial College London
Professor Robert Wilkinson

ProfessorRobertWilkinson

Faculty of Medicine, Department of Infectious Disease

Professor in Infectious Diseases
 
 
 
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Contact

 

r.j.wilkinson Website

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bremer:2021:10.1080/14656566.2021.1940954,
author = {Bremer, M and Kadernani, Y and Wasserman, S and Wilkinson, RJ and Davis, AG},
doi = {10.1080/14656566.2021.1940954},
journal = {Expert Opinion on Pharmacotherapy},
pages = {2053--2070},
title = {Strategies for the diagnosis and management of meningitis in HIV-infected adults in resource limited settings},
url = {http://dx.doi.org/10.1080/14656566.2021.1940954},
volume = {22},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Introduction:The incidence of human immunodeficiency virus-1 (HIV-1) associated meningitis has been declining in the post-combination antiretroviral treatment (ART) era, although survival rates remain low for the common causes like tuberculosis and cryptococcal disease. Diagnosis and treatment of meningitis in HIV-1 is complicated by atypical clinical presentations, limited accuracy of diagnostic tests, access to diagnostic tests, and therapeutic agents in low- and middle-income countries (LMIC) and immune reconstitution inflammatory syndrome (IRIS).Areas covered:We provide an overview of the common etiologies of meningitis in HIV-1-infected adults, suggest a diagnostic approach based on readily available tests, and review specific chemotherapeutic agents, host-directed therapies, supportive care, timing of ART initiation, and considerations in the management of IRIS with a focus on resource-limited settings. They identify key knowledge gaps and suggest areas for future research.Expert opinion:Evidence-based management of HIV-1-associated meningitis is sparse for common etiologies. More readily available and sensitive diagnostic tests as well as standardized investigation strategies are required in LMIC. There is a lack of availability of recommended drugs in areas of high HIV-1 prevalence and a limited pipeline of novel chemotherapeutic agents. Host-directed therapies have been inadequately studied.
AU  - Bremer,M
AU  - Kadernani,Y
AU  - Wasserman,S
AU  - Wilkinson,RJ
AU  - Davis,AG
DO  - 10.1080/14656566.2021.1940954
EP  - 2070
PY  - 2021///
SN  - 1465-6566
SP  - 2053
TI  - Strategies for the diagnosis and management of meningitis in HIV-infected adults in resource limited settings
T2  - Expert Opinion on Pharmacotherapy
UR  - http://dx.doi.org/10.1080/14656566.2021.1940954
UR  - http://hdl.handle.net/10044/1/90317
VL  - 22
ER  -
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