Imperial College London
Professor Robert Wilkinson

ProfessorRobertWilkinson

Faculty of Medicine, Department of Infectious Disease

Professor in Infectious Diseases
 
 
 
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Contact

 

r.j.wilkinson Website

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@unpublished{du:2021:10.1101/2021.05.11.21256479,
author = {du, Bruyn E and Stek, C and Daroowala, R and Said-Hartley, Q and Hsiao, M and Goliath, R and Abrahams, F and Jackson, A and Wasserman, S and Allwood, B and Davis, A and Lai, RP-J and Coussens, A and Wilkinson, K and de, Vries J and Tiffin, N and Cerrone, M and Ntusi, N and Riou, C and Wilkinson, R and Aziz, S and Bangani, N and Black, J and Bremer, M and Burgers, W and Ciko, Z and Esmail, H and Gordon, S and Harley, Y and Lakay, F and Martinez-Estrada, F-O and Meintjes, G and Mendelson, M and Papavarnavas, T and Proust, A and Ruzive, S and Schafer, G and Serole, K and Whitaker, C and Zvinairo, K},
doi = {10.1101/2021.05.11.21256479},
publisher = {Cold Spring Harbor Laboratory},
title = {Communicable and non-communicable co-morbidities and the presentation of COVID-19 in an African setting of high HIV-1 and tuberculosis prevalence},
url = {http://dx.doi.org/10.1101/2021.05.11.21256479},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - UNPB
AB  - Objectives To describe the presentation and outcome of SARS-CoV2 infection in an African setting of high non-communicable co-morbidity and also HIV-1 and tuberculosis prevalence.Design Case control analysis with cases stratified by HIV-1 and tuberculosis status.Setting A single-centre observational case-control study of adults admitted to a South African hospital with proven SARS-CoV-2 infection or alternative diagnosis.Participants 104 adults with RT-PCR-proven SARS-CoV2 infection of which 55 (52.9%) were male and 31 (29.8%) HIV-1 co-infected. 40 adults (35.7% male, 30.9% HIV-1 co-infected) admitted during the same period with no RT-PCR or serological evidence of SARS-CoV2 infection and assigned alternative diagnoses. Additional in vitro data from prior studies of 72 healthy controls and 118 HIV-1 uninfected and infected persons participants enrolled to a prior study with either immune evidence of tuberculosis sensitization but no symptoms or microbiologically confirmed pulmonary tuberculosis.Results Two or more co-morbidities were present in 57.7% of 104 RT-PCR proven COVID-19 presentations, the commonest being hypertension (48%), type 2 diabetes mellitus (39%), obesity (31%) but also HIV-1 (30%) and active tuberculosis (14%). Amongst patients dually infected by tuberculosis and SARS-CoV-2, clinical features could be dominated by either SARS-CoV-2 or tuberculosis: lymphopenia was exacerbated, and some markers of inflammation (D-dimer and ferritin) elevated in singly SARS-CoV-2 infected patients were even further elevated (p < 0.05). HIV-1 and SARS-CoV2 co-infection resulted in lower absolute number and proportion of CD4 lymphocytes, with those in the lowest peripheral CD4 percentage strata exhibiting absent or lower antibody responses against SARS-CoV2. Death occurred in 30/104 (29%) of all COVID-19 patients and in 6/15 (40%) of patients with coincident SARS-CoV-2 and tuberculosis.Conclusions In this South African setting, HIV-1 and tuberculosis are common co-m
AU  - du,Bruyn E
AU  - Stek,C
AU  - Daroowala,R
AU  - Said-Hartley,Q
AU  - Hsiao,M
AU  - Goliath,R
AU  - Abrahams,F
AU  - Jackson,A
AU  - Wasserman,S
AU  - Allwood,B
AU  - Davis,A
AU  - Lai,RP-J
AU  - Coussens,A
AU  - Wilkinson,K
AU  - de,Vries J
AU  - Tiffin,N
AU  - Cerrone,M
AU  - Ntusi,N
AU  - Riou,C
AU  - Wilkinson,R
AU  - Aziz,S
AU  - Bangani,N
AU  - Black,J
AU  - Bremer,M
AU  - Burgers,W
AU  - Ciko,Z
AU  - Esmail,H
AU  - Gordon,S
AU  - Harley,Y
AU  - Lakay,F
AU  - Martinez-Estrada,F-O
AU  - Meintjes,G
AU  - Mendelson,M
AU  - Papavarnavas,T
AU  - Proust,A
AU  - Ruzive,S
AU  - Schafer,G
AU  - Serole,K
AU  - Whitaker,C
AU  - Zvinairo,K
DO  - 10.1101/2021.05.11.21256479
PB  - Cold Spring Harbor Laboratory
PY  - 2021///
TI  - Communicable and non-communicable co-morbidities and the presentation of COVID-19 in an African setting of high HIV-1 and tuberculosis prevalence
UR  - http://dx.doi.org/10.1101/2021.05.11.21256479
UR  - https://www.medrxiv.org/content/10.1101/2021.05.11.21256479v1
UR  - http://hdl.handle.net/10044/1/90289
ER  -
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