Imperial College London
Professor Robert Wilkinson

ProfessorRobertWilkinson

Faculty of Medicine, Department of Infectious Disease

Professor in Infectious Diseases
 
 
 
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Contact

 

r.j.wilkinson Website

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bohrer:2021:10.1084/jem.20210469,
author = {Bohrer, AC and Castro, E and Hu, Z and Queiroz, ATL and Tocheny, CE and Assmann, M and Sakai, S and Nelson, C and Baker, PJ and Ma, H and Wang, L and Zilu, W and du, Bruyn E and Riou, C and Kauffman, KD and Moore, IN and Del, Nonno F and Petrone, L and Goletti, D and Martineau, AR and Lowe, DM and Cronan, MR and Wilkinson, RJ and Barry, CE and Via, LE and Barber, DL and Klion, AD and Andrade, BB and Song, Y and Wong, K-W and Mayer-Barber, KD},
doi = {10.1084/jem.20210469},
journal = {Journal of Experimental Medicine},
pages = {1--20},
title = {Eosinophils are part of the granulocyte response in tuberculosis and promote host resistance in mice},
url = {http://dx.doi.org/10.1084/jem.20210469},
volume = {218},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Host resistance to Mycobacterium tuberculosis (Mtb) infection requires the activities of multiple leukocyte subsets, yet the roles of the different innate effector cells during tuberculosis are incompletely understood. Here we uncover an unexpected association between eosinophils and Mtb infection. In humans, eosinophils are decreased in the blood but enriched in resected human tuberculosis lung lesions and autopsy granulomas. An influx of eosinophils is also evident in infected zebrafish, mice, and nonhuman primate granulomas, where they are functionally activated and degranulate. Importantly, using complementary genetic models of eosinophil deficiency, we demonstrate that in mice, eosinophils are required for optimal pulmonary bacterial control and host survival after Mtb infection. Collectively, our findings uncover an unexpected recruitment of eosinophils to the infected lung tissue and a protective role for these cells in the control of Mtb infection in mice.
AU  - Bohrer,AC
AU  - Castro,E
AU  - Hu,Z
AU  - Queiroz,ATL
AU  - Tocheny,CE
AU  - Assmann,M
AU  - Sakai,S
AU  - Nelson,C
AU  - Baker,PJ
AU  - Ma,H
AU  - Wang,L
AU  - Zilu,W
AU  - du,Bruyn E
AU  - Riou,C
AU  - Kauffman,KD
AU  - Moore,IN
AU  - Del,Nonno F
AU  - Petrone,L
AU  - Goletti,D
AU  - Martineau,AR
AU  - Lowe,DM
AU  - Cronan,MR
AU  - Wilkinson,RJ
AU  - Barry,CE
AU  - Via,LE
AU  - Barber,DL
AU  - Klion,AD
AU  - Andrade,BB
AU  - Song,Y
AU  - Wong,K-W
AU  - Mayer-Barber,KD
DO  - 10.1084/jem.20210469
EP  - 20
PY  - 2021///
SN  - 0022-1007
SP  - 1
TI  - Eosinophils are part of the granulocyte response in tuberculosis and promote host resistance in mice
T2  - Journal of Experimental Medicine
UR  - http://dx.doi.org/10.1084/jem.20210469
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000702879300007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://rupress.org/jem/article/218/10/e20210469/212535/Eosinophils-are-part-of-the-granulocyte-response
UR  - http://hdl.handle.net/10044/1/90731
VL  - 218
ER  -
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