Imperial College London


Faculty of MedicineDepartment of Medicine

Research Associate



+44 (0)20 7594 3058r.kelwick Website




Sir Alexander Fleming BuildingSouth Kensington Campus





Dr Richard Kelwick is an entrepreneurially driven research associate, at Imperial College London, with expertise in both cancer biology and synthetic biology. During his Ph.D. he researched the protective roles of metalloproteinases in cancer. His research led to mechanistic insights into the protective roles of a disintegrin-like and metalloprotease with thrombospondin type motif 15 (ADAMTS15) in breast cancer. Upon moving to Imperial, Dr Kelwick developed expertise in cell-free biotechnology, where he generated several microbial and mammalian cell-free transcription-translation systems for synthetic biology applications. Moving forward Dr Kelwick’s expertise in both cancer biology and synthetic biology will be applied to understanding exosome cancer biology as a means to gain insights into detecting cancers at the earliest stages.

Success in international and national business competitions:

Semi-finalist OneStart [2016], LeanLaunchPad [2015], 3-Day MBA [2014], BBSRC Biotechnology YES [2010], Flux [2008], Regional Enterprise Awards [2007] and The University of Sheffield Business Creation Competition [2007]. 

Project management and leadership experience with successful outcomes:

Founding president of the UEA Enterprise and Engagement Club [2010 - 2012]. Scientific advisor of three successful iGEM teams: Imperial College London [2013] and NRP/UEA/JIC [2011; 2012].

Passion for science communication:

Interviewed on Persian TV. Organised and supported events in the Science Museum, V&A museum, and the Imperial Festival.

Selected Publications

Journal Articles

Wagstaff L, Kelwick R, Decock J, et al., 2010, ADAMTS15 metalloproteinase inhibits breast cancer cell migration., Breast Cancer Research, Vol:12, ISSN:1465-5411, Pages:P15-P15

Kelwick R, Webb AJ, MacDonald JT, et al., 2016, Development of a Bacillus subtilis cell-free transcription-translation system for prototyping regulatory elements, Metabolic Engineering, Vol:38, ISSN:1096-7176, Pages:370-381

Kelwick R, Bowater L, Yeoman KH, et al., 2015, Promoting microbiology education through the iGEM synthetic biology competition., Fems Microbiol Lett, Vol:362

Kelwick R, Desanlis I, Wheeler GN, et al., 2015, The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family., Genome Biology, Vol:16, ISSN:1474-760X, Pages:113-113

Kelwick R, Kopniczky M, Bower I, et al., 2015, A Forward-Design Approach to Increase the Production of Poly-3-Hydroxybutyrate in Genetically Engineered Escherichia coli, PLOS One, Vol:10, ISSN:1932-6203

Kelwick R, Wagstaff L, Decock J, et al., 2015, Metalloproteinase-Dependent and -Independent processes contribute to inhibition of breast cancer cell migration, angiogenesis and liver metastasis by a disintegrin and metalloproteinase with thrombospondin motifs-15, International Journal of Cancer, Vol:136, ISSN:0020-7136, Pages:E14-E26

Kelwick R, MacDonald JT, Webb AJ, et al., 2014, Developments in the tools and methodologies of synthetic biology., Front Bioeng Biotechnol, Vol:2, ISSN:2296-4185

Wagstaff L, Kelwick R, Decock J, et al., 2011, The roles of ADAMTS metalloproteinases in tumorigenesis and metastasis, Frontiers in Bioscience-Landmark, Vol:16, ISSN:1093-9946, Pages:1861-1872

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