Imperial College London

Professor Kitney

Faculty of EngineeringDepartment of Bioengineering

Professor of BioMedical Systems Engineering



+44 (0)20 7594 6226r.kitney Website




Ms Tania Briggs +44 (0)20 7594 6226




3.16Royal School of MinesSouth Kensington Campus






BibTex format

author = {Kitney, RI and Freemont, PS and Rouilly, V},
doi = {10.1049/iet-stb:20070018},
journal = {IET Synthetic Biology},
pages = {68--70},
title = {Engineering a molecular predation oscillator},
url = {},
volume = {1},
year = {2007}

RIS format (EndNote, RefMan)

AB - The paper addresses the problem of designing and building a stable molecular based oscillator which can be controlled in terms of both amplitude and frequency. A study of previous oscillators of this type showed that they are inherently unstable. To overcome this problem a design was chosen which is based on Lotka-Voltera dynamics. An important aspect of the work was the use of what we term the Engineering Cycle; that is, the cycle of system specification, design, modelling, implementation, and testing and validation. The Lotka-Voltera dynamic, in the context of a predation oscillator, amounts to a predator-prey approach. This is the basis of the oscillator design. The oscillator was designed and detailed modelling undertaken to establish the modes of the dynamic; how it could be tuned for stability; and how to control its amplitude and frequency. The biological implementation of the design was undertaken using a number of BioBricks from the MIT registry ( index.php/Main_Page), together with a number of parts which we designed and built. © 2007 The Institution of Engineering and Technology.
AU - Kitney,RI
AU - Freemont,PS
AU - Rouilly,V
DO - 10.1049/iet-stb:20070018
EP - 70
PY - 2007///
SN - 1752-1394
SP - 68
TI - Engineering a molecular predation oscillator
T2 - IET Synthetic Biology
UR -
VL - 1
ER -