Imperial College London

Professor Kitney

Faculty of EngineeringDepartment of Bioengineering

Professor of BioMedical Systems Engineering



+44 (0)20 7594 6226r.kitney Website




Ms Tania Briggs +44 (0)20 7594 6226




3.16Royal School of MinesSouth Kensington Campus






BibTex format

author = {Poh, CL and Kitney, RI and Akhtar, S and Alam, M and Shrestha, R},
pages = {214--217},
title = {Multi-layer biological visualization of cartilage wear},
year = {2007}

RIS format (EndNote, RefMan)

AB - © International Federation for Medical and Biological Engineering 2007. The paper relates to a project on the development of advanced clinical information systems (CIS). These are capable of storing, displaying and manipulating multiple data types across the Biological Continuum (BC) – the continuum which comprises systems, viscera, tissue, cells, proteins and genes. In this context, we address the issue of multi-layer visualization of cartilage wear at the visceral, tissue and cellular levels. In many areas of application there may be a wide range of image data (both 2-D and 3-D) across the BC. In the treatment of cartilage defects, in addition to the use of minimal access surgical techniques, there have been rapid developments in tissue engineering and cell-based therapy. Imaging at all levels of the BC is important in this context in order to undertake effective diagnosis and to monitor the success of treatment. This is generally achieved using different imaging modalities. There is therefore a need to readily access and view the full range of data. This has required the development of visualization and navigation techniques across the levels. As a result, we have developed a web-based interface which allows the viewing of 2-D and 3-D image data from different levels of the BC seamlessly, despite the fact that the data may well be from different modalities. We will present a case study using porcine cadaver knee specimens which have been used to investigate cartilage wear. A number of objectives have been achieved in the study. (i) Geometrically matched sets of images have been obtained from the visceral, tissue and cellular levels of the BC using different imaging modalities (i.e. MRI, light and electron microscopy); (ii) Cartilage wear has been visualized in a manner that will aid diagnosis; (iii) The geometric framework concept has been demonstrated by visualizing the matched sets of data using our interface.
AU - Poh,CL
AU - Kitney,RI
AU - Akhtar,S
AU - Alam,M
AU - Shrestha,R
EP - 217
PY - 2007///
SN - 1680-0737
SP - 214
TI - Multi-layer biological visualization of cartilage wear
ER -