Professor Krams holds a Chair in Molecular Bioengineering at Imperial College, London. Prior to joining Imperial College he worked as Associate Professor in the department Bioengineering, Thoraxcentre Rotterdam, the Netherlands and as associate professor/chair in the department of Medical Physics, Free University in Amsterdam. He received his Medical Degree and Ph.D. from the Free University, Amsterdam in 1989.
His research is focussed on the molecular mechanism underlying biomechanical stimuli. To that end he uses a combination of engineering techniques (imaging, systems biology and synthetic biology) and molecular techniques (high throughput, qPCR, life cell imaging) to study the interaction of gene expression and shear stress and wall stress on cells in culture and in whole animals.
It has led to the development of new devices for patient and experimental studies and to the development of new analysis techniques for images obtained by microscopes. The work that will be started up in London consists of imaging of animals and application of system biology and mult-scale modelling to vascular biology.
Rob’s research publications can be found at the tab above, or on Google Scholar.
World's-first mechanosensitive human cell line produced by Imperial’s Professor Rob Krams now available via Quicktech.
et al., 2015, Inducing Persistent Flow Disturbances Accelerates Atherogenesis and Promotes Thin Cap Fibroatheroma Development in D374Y-PCSK9 Hypercholesterolemic Minipigs, Circulation, Vol:132, ISSN:0009-7322, Pages:1003-1012
et al., 2014, Biomechanical factors in atherosclerosis: mechanisms and clinical implications, European Heart Journal, Vol:35, ISSN:0195-668X, Pages:3013-+
et al., 2008, Towards patient-specific risk assessment of abdominal aortic aneurysm, Medical & Biological Engineering & Computing, Vol:46, ISSN:0140-0118, Pages:1085-1095
et al., 2008, Increased endothelial mitogen-activated protein kinase phosphatase-1 expression suppresses proinflammatory activation at sites that are resistant to atherosclerosis, Circulation Research, Vol:103, ISSN:0009-7330, Pages:726-732
et al., 2009, Activation of Nrf2 in Endothelial Cells Protects Arteries From Exhibiting a Proinflammatory State, Arteriosclerosis Thrombosis and Vascular Biology, Vol:29, ISSN:1079-5642, Pages:1851-U353
et al., 2008, Endothelial primary cilia in areas of disturbed flow are at the base of atherosclerosis, Atherosclerosis, Vol:196, ISSN:0021-9150, Pages:542-550
et al., 2005, Shear stress affects the intracellular distribution of eNOS: direct demonstration by a novel in vivo technique, Blood, Vol:106, ISSN:0006-4971, Pages:3691-3698
et al., 2007, Shear stress-induced changes in atherosclerotic plaque composition are modulated by chemokines, Journal of Clinical Investigation, Vol:117, ISSN:0021-9738, Pages:616-626
et al., 2001, Shear-stress and wall-stress regulation of vascular remodeling after balloon angioplasty - Effect of matrix metalloproteinase inhibition, Circulation, Vol:104, ISSN:0009-7322, Pages:91-96
et al., 2006, Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress, Circulation, Vol:113, ISSN:0009-7322, Pages:2744-2753