Imperial College London

ProfessorRobKrams

Faculty of EngineeringDepartment of Bioengineering

Professor of Molecular Bioengineering
 
 
 
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Contact

 

+44 (0)20 7594 1473r.krams

 
 
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Location

 

3.15Royal School of MinesSouth Kensington Campus

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Summary

 

Summary

Professor Krams holds a Chair in Molecular Bioengineering at Imperial College, London. Prior to joining Imperial College he worked as Associate Professor in the department Bioengineering, Thoraxcentre Rotterdam, the Netherlands and as associate professor/chair in the department of Medical Physics, Free University in Amsterdam.  He received his Medical Degree and Ph.D. from the Free University, Amsterdam in 1989.

His research is focussed on the molecular mechanism underlying biomechanical stimuli. To that end he uses a combination of engineering techniques (imaging, systems biology and synthetic biology) and molecular techniques (high throughput, qPCR, life cell imaging) to study the interaction of gene expression and shear stress and wall stress on cells in culture and in whole animals.

It has led to the development of new devices for patient and experimental studies and to the development of new analysis techniques for images obtained by microscopes. The work that will be started up in London consists of imaging of animals and application of system biology and mult-scale modelling to vascular biology.

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Rob’s research publications can be found at the tab above, or on Google Scholar.

Research highlight

World's-first mechanosensitive human cell line produced by Imperial’s Professor Rob Krams now available via Quicktech.

Selected Publications

Journal Articles

Pedrigi RM, Poulsen CB, Mehta VV, et al., 2015, Inducing Persistent Flow Disturbances Accelerates Atherogenesis and Promotes Thin Cap Fibroatheroma Development in D374Y-PCSK9 Hypercholesterolemic Minipigs, Circulation, Vol:132, ISSN:0009-7322, Pages:1003-1012

Kwak BR, Baeck M, Bochaton-Piallat M-L, et al., 2014, Biomechanical factors in atherosclerosis: mechanisms and clinical implications, European Heart Journal, Vol:35, ISSN:0195-668X, Pages:3013-+

Breeuwer M, de Putter S, Kose U, et al., 2008, Towards patient-specific risk assessment of abdominal aortic aneurysm, Medical & Biological Engineering & Computing, Vol:46, ISSN:0140-0118, Pages:1085-1095

Zakkar M, Chaudhury H, Sandvik G, et al., 2008, Increased endothelial mitogen-activated protein kinase phosphatase-1 expression suppresses proinflammatory activation at sites that are resistant to atherosclerosis, Circulation Research, Vol:103, ISSN:0009-7330, Pages:726-732

Zakkar M, Van der Heiden K, Luong LA, et al., 2009, Activation of Nrf2 in Endothelial Cells Protects Arteries From Exhibiting a Proinflammatory State, Arteriosclerosis Thrombosis and Vascular Biology, Vol:29, ISSN:1079-5642, Pages:1851-U353

Van der Heiden K, Hierck BP, Krams R, et al., 2008, Endothelial primary cilia in areas of disturbed flow are at the base of atherosclerosis, Atherosclerosis, Vol:196, ISSN:0021-9150, Pages:542-550

Cheng C, van Haperen R, de Waard M, et al., 2005, Shear stress affects the intracellular distribution of eNOS: direct demonstration by a novel in vivo technique, Blood, Vol:106, ISSN:0006-4971, Pages:3691-3698

Cheng C, Tempel D, van Haperen R, et al., 2007, Shear stress-induced changes in atherosclerotic plaque composition are modulated by chemokines, Journal of Clinical Investigation, Vol:117, ISSN:0021-9738, Pages:616-626

Wentzel JJ, Kloet J, Andhyiswara I, et al., 2001, Shear-stress and wall-stress regulation of vascular remodeling after balloon angioplasty - Effect of matrix metalloproteinase inhibition, Circulation, Vol:104, ISSN:0009-7322, Pages:91-96

Cheng C, Tempel D, van Haperen R, et al., 2006, Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress, Circulation, Vol:113, ISSN:0009-7322, Pages:2744-2753

More Publications