Robert Leech is an Senior Lecturer within the Division of Brain Sciences and is a member of the Computational, Cognitive and Clinical Neuroimaging Laboratory.
His research is inherently multi-disciplinary, integrating neuroscience, psychology and computer science to better understand the healthy and pathological brain.
His work falls into three interrelated themes, predominantly using structural and functional neuroimaging methodologies:
1. Studying cognition and complex networks in the healthy brain using functional MRI studies of attention, language and memory.
2. Understanding network break down and cognition in a range of neurological disorders, including traumatic brain injury, aphasic stroke and Alzheimer's disease, using diffusion tensor imaging (DTI), FMRI and anatomical MRI.
3. Developing computational models simulating neural dynamics (e.g., see here).
Outside of neuroscience and psychology, he is also interested in theoretical approaches to voting and has co-developed a set of analytic tools for measuring voting power.
et al., 2016, Seeds of neuroendocrine doubt, Nature, Vol:535, ISSN:0028-0836, Pages:E1-E2
et al., 2016, Cortical Entropy, Mutual Information and Scale-Free Dynamics in Waking Mice, Cerebral Cortex, Vol:26, ISSN:1047-3211, Pages:3945-3952
et al., 2016, Neural correlates of the LSD experience revealed by multimodal neuroimaging, Proceedings of the National Academy of Sciences of the United States of America, Vol:113, ISSN:0027-8424, Pages:4853-4858
et al., 2016, Eye Movements during Auditory Attention Predict Individual Differences in Dorsal Attention Network Activity, Frontiers in Human Neuroscience, Vol:10, ISSN:1662-5161
Geranmayeh F, Leech R, Wise RJS, 2016, Network dysfunction predicts speech production after left hemisphere stroke, Neurology, Vol:86, ISSN:0028-3878, Pages:1296-1305
et al., 2016, The Automatic Neuroscientist: A framework for optimizing experimental design with closed-loop real-time fMRI, Neuroimage, Vol:129, ISSN:1053-8119, Pages:320-334
et al., 2016, Local inhibitory plasticity tunes macroscopic brain dynamics and allows the emergence of functional brain networks, Neuroimage, Vol:124, ISSN:1053-8119, Pages:85-95
et al., 2015, Cognitive Flexibility through Metastable Neural Dynamics Is Disrupted by Damage to the Structural Connectome, Journal of Neuroscience, Vol:35, ISSN:0270-6474, Pages:9050-9063
et al., 2015, Effects of lesions on synchrony and metastability in cortical networks, Neuroimage, Vol:118, ISSN:1053-8119, Pages:456-467
Leech R, Braga R, Sharp DJ, 2012, Echoes of the Brain within the Posterior Cingulate Cortex, Journal of Neuroscience, Vol:32, ISSN:0270-6474, Pages:215-222
et al., 2015, Disconnection of network hubs and cognitive impairment after traumatic brain injury, Brain, Vol:138, ISSN:0006-8950, Pages:1696-1709
et al., 2015, Cascades and Cognitive State: Focused Attention Incurs Subcritical Dynamics, Journal of Neuroscience, Vol:35, ISSN:0270-6474, Pages:4626-4634
et al., 2015, Measuring Vascular Reactivity With Breath-Holds After Stroke: A Method to Aid Interpretation of Group-Level BOLD Signal Changes in Longitudinal fMRI Studies, Human Brain Mapping, Vol:36, ISSN:1065-9471, Pages:1755-1771
Cole JH, Leech R, Sharp DJ, 2015, Prediction of Brain Age Suggests Accelerated Atrophy after Traumatic Brain Injury, Annals of Neurology, Vol:77, ISSN:0364-5134, Pages:571-581
et al., 2015, Neural Systems Involved When Attending to a Speaker, Cerebral Cortex, Vol:25, ISSN:1047-3211, Pages:4284-4298
Geranmayeh F, Leech R, Wise RJS, 2015, Semantic retrieval during overt picture description: Left anterior temporal or the parietal lobe?, Neuropsychologia, Vol:76, ISSN:0028-3932, Pages:125-135
et al., 2015, Exploring Spatiotemporal Network Transitions in Task Functional MRI, Human Brain Mapping, Vol:36, ISSN:1065-9471, Pages:1348-1364
et al., 2014, Voltage Imaging of Waking Mouse Cortex Reveals Emergence of Critical Neuronal Dynamics, Journal of Neuroscience, Vol:34, ISSN:0270-6474, Pages:16611-16620
et al., 2014, Enhanced Repertoire of Brain Dynamical States During the Psychedelic Experience, Human Brain Mapping, Vol:35, ISSN:1065-9471, Pages:5442-5456
et al., 2014, Estimating time-varying brain connectivity networks from functional MRI time series, Neuroimage, Vol:103, ISSN:1053-8119, Pages:427-443
et al., 2014, Damage to the Salience Network and Interactions with the Default Mode Network, Journal of Neuroscience, Vol:34, ISSN:0270-6474, Pages:10798-10807
et al., 2014, Overlapping Networks Engaged during Spoken Language Production and Its Cognitive Control, Journal of Neuroscience, Vol:34, ISSN:0270-6474, Pages:8728-8740
et al., 2015, Convergent and Divergent fMRI Responses in Children and Adults to Increasing Language Production Demands, Cerebral Cortex, Vol:25, ISSN:1047-3211, Pages:3261-3277
et al., 2014, The effects of psilocybin and MDMA on between-network resting state functional connectivity in healthy volunteers, Frontiers in Human Neuroscience, Vol:8, ISSN:1662-5161
Erika-Florence M, Leech R, Hampshire A, 2014, A functional network perspective on response inhibition and attentional control, Nature Communications, Vol:5, ISSN:2041-1723
et al., 2014, Spatial Dependencies between Large-Scale Brain Networks, PLOS One, Vol:9, ISSN:1932-6203
et al., 2014, The response of the anterior striatum during adult human vocal learning, Journal of Neurophysiology, Vol:112, ISSN:0022-3077, Pages:792-801
et al., 2014, The neural basis of impaired self-awareness after traumatic brain injury, Brain, Vol:137, ISSN:0006-8950, Pages:586-597
et al., 2014, The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs, Frontiers in Human Neuroscience, Vol:8, ISSN:1662-5161
et al., 2015, The Effects of Acutely Administered 3,4-Methylenedioxymethamphetamine on Spontaneous Brain Function in Healthy Volunteers Measured with Arterial Spin Labeling and Blood Oxygen Level-Dependent Resting State Functional Connectivity, Biological Psychiatry, Vol:78, ISSN:0006-3223, Pages:554-562
Sharp DJ, Scott G, Leech R, 2014, Network dysfunction after traumatic brain injury, Nature Reviews Neurology, Vol:10, ISSN:1759-4758, Pages:156-166
et al., 2014, The Control of Global Brain Dynamics: Opposing Actions of Frontoparietal Control and Default Mode Networks on Attention, Journal of Neuroscience, Vol:34, ISSN:0270-6474, Pages:451-461
et al., 2013, Echoes of the Brain within Default Mode, Association, and Heteromodal Cortices, Journal of Neuroscience, Vol:33, ISSN:0270-6474, Pages:14031-14039
Leech R, Sharp DJ, 2014, The role of the posterior cingulate cortex in cognition and disease, Brain, Vol:137, ISSN:0006-8950, Pages:12-32
et al., 2014, Parallel systems in the control of speech, Human Brain Mapping, Vol:35, ISSN:1065-9471, Pages:1930-1943
et al., 2013, Separable networks for top-down attention to auditory non-spatial and visuospatial modalities, Neuroimage, Vol:74, ISSN:1053-8119, Pages:77-86
et al., 2013, Individual prediction of white matter injury following traumatic brain injury, Annals of Neurology, Vol:73, ISSN:0364-5134, Pages:489-499
et al., 2012, Implications for psychedelic-assisted psychotherapy: functional magnetic resonance imaging study with psilocybin, British Journal of Psychiatry, Vol:200, ISSN:0007-1250, Pages:238-244