Imperial College London

DrRobertLeech

Faculty of MedicineDepartment of Medicine

Senior Lecturer
 
 
 
//

Contact

 

+44 (0)20 7594 7994r.leech

 
 
//

Location

 

Burlington DanesHammersmith Campus

//

Summary

 

Summary

Robert Leech is an Senior Lecturer within the Division of Brain Sciences and is a member of the Computational, Cognitive and Clinical Neuroimaging Laboratory.

His research is inherently multi-disciplinary, integrating neuroscience, psychology and computer science to better understand the healthy and pathological brain. 

His work falls into three interrelated themes, predominantly using structural and functional neuroimaging methodologies:

1. Studying cognition and complex networks in the healthy brain using functional MRI studies of attention, language and memory.

2. Understanding network break down and cognition in a range of neurological disorders, including traumatic brain injury, aphasic stroke and Alzheimer's disease, using diffusion tensor imaging (DTI), FMRI and anatomical MRI. 

3. Developing computational models simulating neural dynamics (e.g., see here).

Outside of neuroscience and psychology, he is also interested in theoretical approaches to voting and has co-developed a set of analytic tools for measuring voting power.

Selected Publications

Journal Articles

Feeney C, Scott GP, Cole JH, et al., 2016, Seeds of neuroendocrine doubt, Nature, Vol:535, ISSN:0028-0836, Pages:E1-E2

Fagerholm ED, Scott G, Shew WL, et al., 2016, Cortical Entropy, Mutual Information and Scale-Free Dynamics in Waking Mice, Cerebral Cortex, Vol:26, ISSN:1047-3211, Pages:3945-3952

Carhart-Harris RL, Muthukumaraswamy S, Roseman L, et al., 2016, Neural correlates of the LSD experience revealed by multimodal neuroimaging, Proceedings of the National Academy of Sciences of the United States of America, Vol:113, ISSN:0027-8424, Pages:4853-4858

Braga RM, Fu RZ, Seemungal BM, et al., 2016, Eye Movements during Auditory Attention Predict Individual Differences in Dorsal Attention Network Activity, Frontiers in Human Neuroscience, Vol:10, ISSN:1662-5161

Geranmayeh F, Leech R, Wise RJS, 2016, Network dysfunction predicts speech production after left hemisphere stroke, Neurology, Vol:86, ISSN:0028-3878, Pages:1296-1305

Lorenz R, Monti RP, Violante IR, et al., 2016, The Automatic Neuroscientist: A framework for optimizing experimental design with closed-loop real-time fMRI, Neuroimage, Vol:129, ISSN:1053-8119, Pages:320-334

Hellyer PJ, Jachs B, Clopath C, et al., 2016, Local inhibitory plasticity tunes macroscopic brain dynamics and allows the emergence of functional brain networks, Neuroimage, Vol:124, ISSN:1053-8119, Pages:85-95

Hellyer PJ, Scott G, Shanahan M, et al., 2015, Cognitive Flexibility through Metastable Neural Dynamics Is Disrupted by Damage to the Structural Connectome, Journal of Neuroscience, Vol:35, ISSN:0270-6474, Pages:9050-9063

Vasa F, Shanahan M, Hellyer PJ, et al., 2015, Effects of lesions on synchrony and metastability in cortical networks, Neuroimage, Vol:118, ISSN:1053-8119, Pages:456-467

Fagerholm ED, Hellyer PJ, Scott G, et al., 2015, Disconnection of network hubs and cognitive impairment after traumatic brain injury, Brain, Vol:138, ISSN:0006-8950, Pages:1696-1709

Fagerholm ED, Lorenz R, Scott G, et al., 2015, Cascades and Cognitive State: Focused Attention Incurs Subcritical Dynamics, Journal of Neuroscience, Vol:35, ISSN:0270-6474, Pages:4626-4634

Geranmayeh F, Wise RJS, Leech R, et al., 2015, Measuring Vascular Reactivity With Breath-Holds After Stroke: A Method to Aid Interpretation of Group-Level BOLD Signal Changes in Longitudinal fMRI Studies, Human Brain Mapping, Vol:36, ISSN:1065-9471, Pages:1755-1771

Kamourieh S, Braga RM, Leech R, et al., 2015, Neural Systems Involved When Attending to a Speaker, Cerebral Cortex, Vol:25, ISSN:1047-3211, Pages:4284-4298

Cole JH, Leech R, Sharp DJ, 2015, Prediction of Brain Age Suggests Accelerated Atrophy after Traumatic Brain Injury, Annals of Neurology, Vol:77, ISSN:0364-5134, Pages:571-581

Scott G, Hellyer PJ, Hampshire A, et al., 2015, Exploring Spatiotemporal Network Transitions in Task Functional MRI, Human Brain Mapping, Vol:36, ISSN:1065-9471, Pages:1348-1364

Geranmayeh F, Leech R, Wise RJS, 2015, Semantic retrieval during overt picture description: Left anterior temporal or the parietal lobe?, Neuropsychologia, Vol:76, ISSN:0028-3932, Pages:125-135

Scott G, Fagerholm ED, Mutoh H, et al., 2014, Voltage Imaging of Waking Mouse Cortex Reveals Emergence of Critical Neuronal Dynamics, Journal of Neuroscience, Vol:34, ISSN:0270-6474, Pages:16611-16620

Tagliazucchi E, Carhart-Harris R, Leech R, et al., 2014, Enhanced Repertoire of Brain Dynamical States During the Psychedelic Experience, Human Brain Mapping, Vol:35, ISSN:1065-9471, Pages:5442-5456

Jilka SR, Scott G, Ham T, et al., 2014, Damage to the Salience Network and Interactions with the Default Mode Network, Journal of Neuroscience, Vol:34, ISSN:0270-6474, Pages:10798-10807

Monti RP, Hellyer P, Sharp D, et al., 2014, Estimating time-varying brain connectivity networks from functional MRI time series, Neuroimage, Vol:103, ISSN:1053-8119, Pages:427-443

Geranmayeh F, Wise RJS, Mehta A, et al., 2014, Overlapping Networks Engaged during Spoken Language Production and Its Cognitive Control, Journal of Neuroscience, Vol:34, ISSN:0270-6474, Pages:8728-8740

Krishnan S, Leech R, Mercure E, et al., 2015, Convergent and Divergent fMRI Responses in Children and Adults to Increasing Language Production Demands, Cerebral Cortex, Vol:25, ISSN:1047-3211, Pages:3261-3277

Leech R, Scott G, Carhart-Harris R, et al., 2014, Spatial Dependencies between Large-Scale Brain Networks, PLOS One, Vol:9, ISSN:1932-6203

Simmonds AJ, Leech R, Iverson P, et al., 2014, The response of the anterior striatum during adult human vocal learning, Journal of Neurophysiology, Vol:112, ISSN:0022-3077, Pages:792-801

Sharp DJ, Scott G, Leech R, 2014, Network dysfunction after traumatic brain injury, Nature Reviews Neurology, Vol:10, ISSN:1759-4758, Pages:156-166

Carhart-Harris RL, Leech R, Hellyer PJ, et al., 2014, The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs, Frontiers in Human Neuroscience, Vol:8, ISSN:1662-5161

Ham TE, Bonnelle V, Hellyer P, et al., 2014, The neural basis of impaired self-awareness after traumatic brain injury, Brain, Vol:137, ISSN:0006-8950, Pages:586-597

Carhart-Harris RL, Murphy K, Leech R, et al., 2015, The Effects of Acutely Administered 3,4-Methylenedioxymethamphetamine on Spontaneous Brain Function in Healthy Volunteers Measured with Arterial Spin Labeling and Blood Oxygen Level-Dependent Resting State Functional Connectivity, Biological Psychiatry, Vol:78, ISSN:0006-3223, Pages:554-562

Hellyer PJ, Shanahan M, Scott G, et al., 2014, The Control of Global Brain Dynamics: Opposing Actions of Frontoparietal Control and Default Mode Networks on Attention, Journal of Neuroscience, Vol:34, ISSN:0270-6474, Pages:451-461

Erika-Florence M, Leech R, Hampshire A, 2014, A functional network perspective on response inhibition and attentional control, Nature Communications, Vol:5, ISSN:2041-1723

Roseman L, Leech R, Feilding A, et al., 2014, The effects of psilocybin and MDMA on between-network resting state functional connectivity in healthy volunteers, Frontiers in Human Neuroscience, Vol:8, ISSN:1662-5161

Braga RM, Sharp DJ, Leeson C, et al., 2013, Echoes of the Brain within Default Mode, Association, and Heteromodal Cortices, Journal of Neuroscience, Vol:33, ISSN:0270-6474, Pages:14031-14039

Leech R, Sharp DJ, 2014, The role of the posterior cingulate cortex in cognition and disease, Brain, Vol:137, ISSN:0006-8950, Pages:12-32

Simmonds AJ, Wise RJS, Collins C, et al., 2014, Parallel systems in the control of speech, Human Brain Mapping, Vol:35, ISSN:1065-9471, Pages:1930-1943

Braga RM, Wilson LR, Sharp DJ, et al., 2013, Separable networks for top-down attention to auditory non-spatial and visuospatial modalities, Neuroimage, Vol:74, ISSN:1053-8119, Pages:77-86

Hellyer PJ, Leech R, Ham TE, et al., 2013, Individual prediction of white matter injury following traumatic brain injury, Annals of Neurology, Vol:73, ISSN:0364-5134, Pages:489-499

Carhart-Harris RL, Leech R, Williams TM, et al., 2012, Implications for psychedelic-assisted psychotherapy: functional magnetic resonance imaging study with psilocybin, British Journal of Psychiatry, Vol:200, ISSN:0007-1250, Pages:238-244

Leech R, Braga R, Sharp DJ, 2012, Echoes of the Brain within the Posterior Cingulate Cortex, Journal of Neuroscience, Vol:32, ISSN:0270-6474, Pages:215-222

More Publications