Imperial College London

DrRobertMahen

Faculty of Natural SciencesDepartment of Physics

Academic Visitor
 
 
 
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Contact

 

r.mahen

 
 
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Location

 

Blackett LaboratorySouth Kensington Campus

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Summary

 

Summary

I investigate mechanisms of intracellular organelle formation and how they go awry to cause disease. The overarching questions which drive my research are:

- How does centrosomal structure self-organise from protein subunits?

- What are the molecular programmes which control changes in centrosomal state?

- How are organelles altered during pathology and can we therapeutically rebuild and repair them?


Publications

Journals

Mahen R, 2018, Stable centrosomal roots disentangle to allow interphase centriole independence, Plos Biology, Vol:16, ISSN:1545-7885

Isokane M, Walter T, Mahen R, et al., 2016, ARHGEF17 is an essential spindle assembly checkpoint factor that targets Mps1 to kinetochores, Journal of Cell Biology, Vol:212, ISSN:0021-9525, Pages:647-659

Wachsmuth M, Conrad C, Bulkescher J, et al., 2015, High-throughput fluorescence correlation spectroscopy enables analysis of proteome dynamics in living cells, Nature Biotechnology, Vol:33, ISSN:1087-0156, Pages:384-389

Keller D, Orpinell M, Olivier N, et al., 2014, Mechanisms of HsSAS-6 assembly promoting centriole formation in human cells, Journal of Cell Biology, Vol:204, ISSN:0021-9525, Pages:697-712

Mahen R, Koch B, Wachsmuth M, et al., 2014, Comparative assessment of fluorescent transgene methods for quantitative imaging in human cells, Molecular Biology of the Cell, Vol:25, ISSN:1059-1524, Pages:3610-3618

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