I investigate mechanisms of intracellular organelle formation and how they go awry to cause disease. The overarching questions which drive my research are:
- How does centrosomal structure self-organise from protein subunits?
- What are the molecular programmes which control changes in centrosomal state?
- How are organelles altered during pathology and can we therapeutically rebuild and repair them?
Mahen R, 2018, Stable centrosomal roots disentangle to allow interphase centriole independence, Plos Biology, Vol:16, ISSN:1545-7885
et al., 2016, ARHGEF17 is an essential spindle assembly checkpoint factor that targets Mps1 to kinetochores, Journal of Cell Biology, Vol:212, ISSN:0021-9525, Pages:647-659
et al., 2015, High-throughput fluorescence correlation spectroscopy enables analysis of proteome dynamics in living cells, Nature Biotechnology, Vol:33, ISSN:1087-0156, Pages:384-389
et al., 2014, Mechanisms of HsSAS-6 assembly promoting centriole formation in human cells, Journal of Cell Biology, Vol:204, ISSN:0021-9525, Pages:697-712
et al., 2014, Comparative assessment of fluorescent transgene methods for quantitative imaging in human cells, Molecular Biology of the Cell, Vol:25, ISSN:1059-1524, Pages:3610-3618