Imperial College London


Faculty of Natural SciencesDepartment of Physics

Academic Visitor







Blackett LaboratorySouth Kensington Campus





I investigate mechanisms of intracellular organelle formation and how they go awry to cause disease. The overarching questions which drive my research are:

- How does centrosomal structure self-organise from protein subunits?

- What are the molecular programmes which control changes in centrosomal state?

- How are organelles altered during pathology and can we therapeutically rebuild and repair them?



Mahen R, 2018, Stable centrosomal roots disentangle to allow interphase centriole independence, Plos Biology, Vol:16, ISSN:1545-7885

Isokane M, Walter T, Mahen R, et al., 2016, ARHGEF17 is an essential spindle assembly checkpoint factor that targets Mps1 to kinetochores, Journal of Cell Biology, Vol:212, ISSN:0021-9525, Pages:647-659

Wachsmuth M, Conrad C, Bulkescher J, et al., 2015, High-throughput fluorescence correlation spectroscopy enables analysis of proteome dynamics in living cells, Nature Biotechnology, Vol:33, ISSN:1087-0156, Pages:384-389

Keller D, Orpinell M, Olivier N, et al., 2014, Mechanisms of HsSAS-6 assembly promoting centriole formation in human cells, Journal of Cell Biology, Vol:204, ISSN:0021-9525, Pages:697-712

Mahen R, Koch B, Wachsmuth M, et al., 2014, Comparative assessment of fluorescent transgene methods for quantitative imaging in human cells, Molecular Biology of the Cell, Vol:25, ISSN:1059-1524, Pages:3610-3618

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