Imperial College London
Alternate

Dr. Rebekah E. T. Moore

Faculty of Engineering, Department of Earth Science & Engineering

Research Fellow
 
 
 
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Contact

 

r.moore13 Website

 
 
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Location

 

4.40/20Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Rehkamper:2019:10.1039/c9mt00160c,
author = {Rehkamper, M and Moore, R and Maret, W and Larner, F},
doi = {10.1039/c9mt00160c},
journal = {Metallomics},
pages = {1506--1517},
title = {Assessment of coupled Zn concentration and natural stable isotope analyses of urine as a novel probe of Zn status},
url = {http://dx.doi.org/10.1039/c9mt00160c},
volume = {11},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Zinc is a common trace metal in the human body, present in about 10% of proteins. Despite numerous roles of Zn in health and disease, there is still a need for a robust biomarker of Zn status. Many parameters have been proposed, with varying levels of success, with plasma Zn often favoured. This study investigates if Zn status can be assessed from the natural stable Zn isotope composition of urine. To this end, 60 urine samples were analysed from ten healthy participants. Remarkably, samples with lower Zn concentrations are systematically enriched in heavy Zn isotopes. Most of the low-Zn urine originated from individuals who omitted dairy, meat or both from their diets. When data for blood serum from age-matched, healthy individuals are compared with the urine results, the former plot at the extension of the urine trend at higher Zn concentrations and lighter isotope compositions. The observed co-variation of Zn isotope compositions with concentrations is indicative of an isotope fractionation system where both properties are controlled by the same processes. It is interpreted as arising from filtration and/or reabsorption processes within the kidney, which are associated with absorbed dietary Zn. The data suggest that the Zn in blood serum that is bound to low molecular weight molecules has an isotope composition distinct from total serum, due to the different affinities of molecular Zn-binding residues to heavy and light Zn isotopes. This technique provides additional information into an individual's Zn status compared to urine or plasma Zn levels alone.
AU  - Rehkamper,M
AU  - Moore,R
AU  - Maret,W
AU  - Larner,F
DO  - 10.1039/c9mt00160c
EP  - 1517
PY  - 2019///
SN  - 1756-5901
SP  - 1506
TI  - Assessment of coupled Zn concentration and natural stable isotope analyses of urine as a novel probe of Zn status
T2  - Metallomics
UR  - http://dx.doi.org/10.1039/c9mt00160c
UR  - https://pubs.rsc.org/en/content/articlelanding/2019/MT/C9MT00160C#!divAbstract
UR  - http://hdl.handle.net/10044/1/72751
VL  - 11
ER  -
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