Imperial College London
Alternate

Dr. Rebekah E. T. Moore

Faculty of Engineering, Department of Earth Science & Engineering

Research Fellow
 
 
 
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Contact

 

r.moore13 Website

 
 
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Location

 

4.40/20Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sullivan:2021:mtomcs/mfab027,
author = {Sullivan, KV and Moore, RET and Capper, MS and Schilling, K and Goddard, K and Ion, C and Layton-Matthews, D and Leybourne, MI and Coles, B and Kreissig, K and Coombes, RC and Larner, F and Rehkamper, M},
doi = {mtomcs/mfab027},
journal = {Matallomics},
pages = {1--12},
title = {Zinc stable isotope analysis reveals Zn dyshomeostasis in benign tumours,  breast cancer, and adjacent histologically normal tissue},
url = {http://dx.doi.org/10.1093/mtomcs/mfab027},
volume = {13},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The disruption of Zn homeostasis has been linked with breast cancer development and progression. To enhance our understanding of changes in Zn homeostasis both inside and around the tumour microenvironment, Zn concentrations and isotopic compositions (δ66Zn) were determined in benign (BT) and malignant (MT) tumours, healthy tissue from reduction mammoplasty (HT), and histologically normal tissue adjacent to benign (NAT(BT)) and malignant tumours (NAT(MT)). Mean Zn concentrations in NAT(BT) are 5.5 µg g−1 greater than in NAT(MT) (p = 0.00056) and 5.1 µg g−1 greater than in HT (p = 0.0026). Zinc concentrations in MT are 12.9 µg g−1 greater than in HT (p = 0.00012) and 13.3 µg g−1 greater than in NAT(MT) (p < 0.0001), whereas δ66Zn is 0.17‰ lower in MT than HT (p = 0.017). Benign tumour Zn concentrations are also elevated compared to HT (p = 0.00013), but are not significantly elevated compared to NAT(BT) (p = 0.32). The δ66Zn of BT is 0.15‰ lower than in NAT(BT) (p = 0.045). The similar light δ66Zn of BT and MT compared to HT and NAT may be related to the isotopic compensation of increased metallothionein (64Zn-rich) expression by activated matrix metalloproteinase (66Zn-rich) in MT, and indicates a resultant 66Zn-rich reservoir may exist in patients with breast tumours. Zinc isotopic compositions thus show promise as a potential diagnostic tool for the detection of breast tumours. The revealed differences of Zn accumulation in healthy and tumour-adjacent tissues require additional investigation.
AU  - Sullivan,KV
AU  - Moore,RET
AU  - Capper,MS
AU  - Schilling,K
AU  - Goddard,K
AU  - Ion,C
AU  - Layton-Matthews,D
AU  - Leybourne,MI
AU  - Coles,B
AU  - Kreissig,K
AU  - Coombes,RC
AU  - Larner,F
AU  - Rehkamper,M
DO  - mtomcs/mfab027
EP  - 12
PY  - 2021///
SN  - 1756-591X
SP  - 1
TI  - Zinc stable isotope analysis reveals Zn dyshomeostasis in benign tumours,  breast cancer, and adjacent histologically normal tissue
T2  - Matallomics
UR  - http://dx.doi.org/10.1093/mtomcs/mfab027
UR  - https://academic.oup.com/metallomics/article/13/6/mfab027/6273136
UR  - http://hdl.handle.net/10044/1/89585
VL  - 13
ER  -
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