Imperial College London

DrRogerNewson

Faculty of MedicineSchool of Public Health

Research Associate
 
 
 
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Contact

 

+44 (0)20 7594 2784r.newson Website

 
 
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Assistant

 

Mrs Pirkko Carmack +44 (0)20 7594 3368

 
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Location

 

351Reynolds BuildingCharing Cross Campus

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Summary

 

Publications

Publication Type
Year
to

139 results found

Figgitt M, Newson R, Leslie I, Fisher J, Ingham E, Case Cet al., 2011, Genomic instability induced by orthopaedic wear debris in cultured human fibroblasts, TOXICOLOGY, Vol: 290, Pages: 115-116, ISSN: 0300-483X

Journal article

Sood A, Salih S, Roh D, Lacharme-Lora L, Parry M, Hardiman B, Keehan R, Grummer R, Winterhager E, Gokhale PJ, Andrews PW, Abbott C, Forbes K, Westwood M, Aplin JD, Ingham E, Papageorgiou I, Berry M, Liu J, Dick AD, Garland RJ, Williams N, Singh R, Simon AK, Lewis M, Ham J, Roger L, Baird DM, Crompton LA, Caldwell MA, Swalwell H, Birch-Machin M, Lopez-Castejon G, Randall A, Lin H, Suleiman M-S, Evans WH, Newson R, Case CPet al., 2011, Signalling of DNA damage and cytokines across cell barriers exposed to nanoparticles depends on barrier thickness, NATURE NANOTECHNOLOGY, Vol: 6, Pages: 824-833, ISSN: 1748-3387

Journal article

Hastan D, Fokkens WJ, Bachert C, Newson RB, Bislimovska J, Bockelbrink A, Bousquet PJ, Brozek G, Bruno A, Dahlen SE, Forsberg B, Gunnbjornsdottir M, Kasper L, Kraemer U, Kowalski ML, Lange B, Lundback B, Salagean E, Todo-Bom A, Tomassen P, Toskala E, van Drunen CM, Bousquet J, Zuberbier T, Jarvis D, Burney Pet al., 2011, Chronic rhinosinusitis in Europe - an underestimated disease. A GA(2)LEN study, ALLERGY, Vol: 66, Pages: 1216-1223, ISSN: 0105-4538

Journal article

Hastan D, Fokkens W, Bachert C, Tomassen P, Newson R, Jarvis D, Bislimovska J, Bockelbrink A, Bousquet P, Bousquet J, Brozek G, Bruno A, Dahlen S, Forsberg B, Gunnbjoernsdottir M, Kasper L, Kraemer U, Kowalski M, Lange B, Lundbaeck B, Salagean M, Todo-Bom A, Toskala E, Zuberbier Tet al., 2011, Chronic rhinosinusitis in Europe - an underestimated disease. A GA(2)LEN study, 30th Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI), Publisher: WILEY-BLACKWELL, Pages: 128-128, ISSN: 0105-4538

Conference paper

Tomassen P, Newson RB, Hoffmans R, Lotvall J, Cardell LO, Gunnbjornsdottir M, Thilsing T, Matricardi P, Kraemer U, Makowska JS, Brozek G, Gjomarkaj M, Howarth P, Loureiro C, Toskala E, Fokkens W, Bachert C, Burney P, Jarvis Det al., 2011, Reliability of EP3OS symptom criteria and nasal endoscopy in the assessment of chronic rhinosinusitis - a GA2LEN study, ALLERGY, Vol: 66, Pages: 556-561, ISSN: 0105-4538

Journal article

Jarvis DL, Natiuc L, Newson PB, 2010, ASTHMA, PUBERTY AND BMI IN THE 1958 BRITISH BIRTH COHORT, British-Thoracic-Society-Winter-Meeting 2010, Publisher: B M J PUBLISHING GROUP, Pages: A51-A51, ISSN: 0040-6376

Conference paper

Shaheen SO, Newson RB, Ring SM, Rose-Zerilli MJ, Holloway JW, Henderson AJet al., 2010, Prenatal and infant acetaminophen exposure, antioxidant gene polymorphisms, and childhood asthma, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 126, Pages: 1141-U124, ISSN: 0091-6749

Journal article

Henderson AJ, Newson RB, Rose-Zerilli M, Ring SM, Holloway JW, Shaheen SOet al., 2010, Maternal Nrf2 and gluthathione-S-transferase polymorphisms do not modify associations of prenatal tobacco smoke exposure with asthma and lung function in school-aged children, THORAX, Vol: 65, Pages: 897-902, ISSN: 0040-6376

Journal article

Shaheen SO, Newson RB, Smith GD, Henderson AJet al., 2010, Prenatal paracetamol exposure and asthma: further evidence against confounding, INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, Vol: 39, Pages: 790-794, ISSN: 0300-5771

Journal article

Parry MC, Bhabra G, Sood A, Machado F, Cartwright L, Saunders M, Ingham E, Newson R, Blom AW, Case CPet al., 2010, Thresholds for indirect DNA damage across cellular barriers for orthopaedic biomaterials, BIOMATERIALS, Vol: 31, Pages: 4477-4483, ISSN: 0142-9612

Journal article

Figgitt M, Newson R, Leslie IJ, Fisher J, Ingham E, Case CPet al., 2010, The genotoxicity of physiological concentrations of chromium (Cr(III) and Cr(VI)) and cobalt (Co(II)): An in vitro study, MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, Vol: 688, Pages: 53-61, ISSN: 0027-5107

Journal article

Cogan N, Baird DM, Phillips R, Crompton LA, Caldwell MA, Rubio MA, Newson R, Lyng F, Case CPet al., 2010, DNA damaging bystander signalling from stem cells, cancer cells and fibroblasts after Cr(VI) exposure and its dependence on telomerase, MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, Vol: 683, Pages: 1-8, ISSN: 0027-5107

Journal article

Newson RB, 2010, Frequentist q-values for multiple-test procedures, STATA JOURNAL, Vol: 10, Pages: 568-584, ISSN: 1536-867X

Journal article

Newson RB, 2010, Comparing the predictive powers of survival models using Harrell's C or Somers' D, STATA JOURNAL, Vol: 10, Pages: 339-358, ISSN: 1536-867X

Journal article

Minelli C, Granell R, Newson R, Rose-Zerilli MJ, Torrent M, Ring SM, Holloway JW, Shaheen SO, Henderson JAet al., 2009, Glutathione-S-transferase genes and asthma phenotypes: a Human Genome Epidemiology (HuGE) systematic review and meta-analysis including unpublished data, International Journal of Epidemiology, Vol: 39, Pages: 539-562, ISSN: 1464-3685

Background Oxidative stress is thought to be involved in the pathogenesis of asthma. Glutathione-S-transferase (GST) enzymes, which play an important role in antioxidant defences, may therefore influence asthma risk. Two common deletion polymorphisms of GSTM1 and GSTT1 genes and the GSTP1 Ile105Val polymorphism have been associated with asthma in children and adults, but results are inconsistent across studies.Methods Systematic review and meta-analysis of the effects of GST genes on asthma, wheezing and bronchial hyper-responsiveness (BHR), with inclusion of unpublished data from three studies, including the large Avon Longitudinal Study of Parents and Children (ALSPAC). Random effect or fixed effect models were used as appropriate, and sensitivity analyses were performed to assess the impact of study characteristics and quality on pooled results.Results The meta-analyses of GSTM1 (n = 22 studies) and GSTT1 (n = 19) showed increased asthma risk associated with the null genotype, but there was extreme between-study heterogeneity and publication bias and the association disappeared when meta-analysis was restricted to the largest studies. Meta-analysis of GSTP1 Ile105Val (n = 17) and asthma suggested a possible protective effect of the Val allele, but heterogeneity was extreme. Few studies evaluated wheezing and BHR and most reported no associations, although weak evidence was found for positive associations of GSTM1 null and GSTP1 Val allele with wheezing and a negative association of GSTP1 Val allele with BHR.Conclusions Our findings do not support a substantial role of GST genes alone in the development of asthma. Future studies of large size should focus on interactions of GST genes with environmental oxidative exposures and with other genes involved in antioxidant pathways. Quality of study conduct and reporting needs to be improved to increase credibility of the evidence accumulating over time.

Journal article

Bhabra G, Sood A, Fisher B, Cartwright L, Saunders M, Evans WH, Surprenant A, Lopez-Castejon G, Mann S, Davis SA, Hails LA, Ingham E, Verkade P, Lane J, Heesom K, Newson R, Case CPet al., 2009, Nanoparticles can cause DNA damage across a cellular barrier, NATURE NANOTECHNOLOGY, Vol: 4, Pages: 876-883, ISSN: 1748-3387

Journal article

Shaheen SO, Northstone K, Newson RB, Emmett PM, Sherriff A, Henderson AJet al., 2009, Dietary patterns in pregnancy and respiratory and atopic outcomes in childhood, THORAX, Vol: 64, Pages: 411-417, ISSN: 0040-6376

Journal article

Glaviano A, Mothersill C, Case CP, Rubio MA, Newson R, Lyng Fet al., 2009, Effects of hTERT on genomic instability caused by either metal or radiation or combined exposure, MUTAGENESIS, Vol: 24, Pages: 25-33, ISSN: 0267-8357

Journal article

Papageorgiou I, Shadrick V, Davis S, Hails L, Schins R, Newson R, Fisher J, Ingham E, Case CPet al., 2008, Macrophages detoxify the genotoxic and cytotoxic effects of surgical cobalt chrome alloy particles but not quartz particles on human cells in vitro, MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, Vol: 643, Pages: 11-19, ISSN: 0027-5107

Journal article

Burney PGJ, Newson RB, Burrows MS, Wheeler DMet al., 2008, The effects of allergens in outdoor air on both atopic and nonatopic subjects with airway disease, ALLERGY, Vol: 63, Pages: 542-546, ISSN: 0105-4538

Journal article

Garcia-Larsen V, Newson RB, Potts JF, Tumilty MK, Shaheen SOet al., 2007, Dietary intake of fruit and childhood asthma, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A21-A21, ISSN: 0040-6376

Conference paper

Henderson AJ, Newson RB, Holloway JW, Rose-Zerilli MJ, Pembrey ME, Ring SM, Shaheen SOet al., 2007, Maternal and child glutathione-S-transferase M1 and T1 polymorphisms modify effect of maternal smoking in pregnancy on childhood lung function, EARLY HUMAN DEVELOPMENT, Vol: 83, Pages: S97-S97, ISSN: 0378-3782

Journal article

Shaheen SO, Newson RB, Holloway JW, Rose-Zerilli MJ, Pembrey ME, Ring SM, Henderson AJet al., 2007, Maternal and child glutathione-S-transferase M1 polymorphism modifies risk of childhood asthma associated with prenatal paracetamol exposure, EARLY HUMAN DEVELOPMENT, Vol: 83, Pages: S59-S60, ISSN: 0378-3782

Journal article

Forbes L, Harvey S, Newson R, Jarvis D, Luczynska C, Price J, Burney Pet al., 2007, Risk factors for accident and emergency (A & E) attendance for asthma in inner city children, THORAX, Vol: 62, Pages: 855-860, ISSN: 0040-6376

Journal article

Hutchinson M, Gurney S, Newson R, 2007, GDNF in Parkinson disease: An object lesson in the tyranny of type II, JOURNAL OF NEUROSCIENCE METHODS, Vol: 163, Pages: 190-192, ISSN: 0165-0270

Journal article

Papageorgiou I, Brown C, Schins R, Singh S, Newson R, Davis S, Fisher J, Ingham E, Case CPet al., 2007, The effect of nano- and micron-sized particles of cobalt-chromium alloy on human fibroblasts in vitro, BIOMATERIALS, Vol: 28, Pages: 2946-2958, ISSN: 0142-9612

Journal article

Okoko BJ, Burney PG, Newson RB, Potts JF, Shaheen SOet al., 2007, Childhood asthma and fruit consumption, EUROPEAN RESPIRATORY JOURNAL, Vol: 29, Pages: 1161-1168, ISSN: 0903-1936

Journal article

Papageorgiou I, Yin Z, Ladon D, Baird D, Lewis AC, Sood A, Newson R, Learmonth ID, Case CPet al., 2007, Genotoxic effects of particles of surgical cobalt chrome alloy on human cells of different age in vitro, MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, Vol: 619, Pages: 45-58, ISSN: 0027-5107

Journal article

Shaheen SO, Newson RB, Rayman MP, Wong AP-L, Tumilty MK, Phillips JM, Potts JF, Kelly FJ, White PT, Burney PGJet al., 2007, Randomised, double blind, placebo-controlled trial of selenium supplementation in adult asthma, THORAX, Vol: 62, Pages: 483-490, ISSN: 0040-6376

Journal article

Shaheen SO, Hines M, Newson RB, Wheeler M, Herrick DRM, Strachan DP, Jones RW, Burney PGJ, Henderson AJet al., 2007, Maternal testosterone in pregnancy and atopic outcomes in childhood, ALLERGY, Vol: 62, Pages: 25-32, ISSN: 0105-4538

Journal article

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