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@article{Chatterjee:2016:10.2337/dc15-1588,
author = {Chatterjee, S and Peters, SAE and Woodward, M and Mejia, Arango S and Batty, GD and Beckett, N and Beiser, A and Borenstein, AR and Crane, PK and Haan, M and Hassing, LB and Hayden, KM and Kiyohara, Y and Larson, EB and Li, C-Y and Ninomiya, T and Ohara, T and Peters, R and Russ, TC and Seshadri, S and Strand, BH and Walker, R and Xu, W and Huxley, RR},
doi = {10.2337/dc15-1588},
journal = {Diabetes Care},
pages = {300--307},
title = {Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of Dementia},
url = {http://dx.doi.org/10.2337/dc15-1588},
volume = {39},
year = {2016}
}

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TY  - JOUR
AB  - OBJECTIVE Type 2 diabetes confers a greater excess risk of cardiovascular disease in women than in men. Diabetes is also a risk factor for dementia, but whether the association is similar in women and men remains unknown. We performed a meta-analysis of unpublished data to estimate the sex-specific relationship between women and men with diabetes with incident dementia.RESEARCH DESIGN AND METHODS A systematic search identified studies published prior to November 2014 that had reported on the prospective association between diabetes and dementia. Study authors contributed unpublished sex-specific relative risks (RRs) and 95% CIs on the association between diabetes and all dementia and its subtypes. Sex-specific RRs and the women-to-men ratio of RRs (RRRs) were pooled using random-effects meta-analyses.RESULTS Study-level data from 14 studies, 2,310,330 individuals, and 102,174 dementia case patients were included. In multiple-adjusted analyses, diabetes was associated with a 60% increased risk of any dementia in both sexes (women: pooled RR 1.62 [95% CI 1.45–1.80]; men: pooled RR 1.58 [95% CI 1.38–1.81]). The diabetes-associated RRs for vascular dementia were 2.34 (95% CI 1.86–2.94) in women and 1.73 (95% CI 1.61–1.85) in men, and for nonvascular dementia, the RRs were 1.53 (95% CI 1.35–1.73) in women and 1.49 (95% CI 1.31–1.69) in men. Overall, women with diabetes had a 19% greater risk for the development of vascular dementia than men (multiple-adjusted RRR 1.19 [95% CI 1.08–1.30]; P < 0.001).CONCLUSIONS Individuals with type 2 diabetes are at ∼60% greater risk for the development of dementia compared with those without diabetes. For vascular dementia, but not for nonvascular dementia, the additional risk is greater in women.
AU  - Chatterjee,S
AU  - Peters,SAE
AU  - Woodward,M
AU  - Mejia,Arango S
AU  - Batty,GD
AU  - Beckett,N
AU  - Beiser,A
AU  - Borenstein,AR
AU  - Crane,PK
AU  - Haan,M
AU  - Hassing,LB
AU  - Hayden,KM
AU  - Kiyohara,Y
AU  - Larson,EB
AU  - Li,C-Y
AU  - Ninomiya,T
AU  - Ohara,T
AU  - Peters,R
AU  - Russ,TC
AU  - Seshadri,S
AU  - Strand,BH
AU  - Walker,R
AU  - Xu,W
AU  - Huxley,RR
DO  - 10.2337/dc15-1588
EP  - 307
PY  - 2016///
SN  - 1935-5548
SP  - 300
TI  - Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of Dementia
T2  - Diabetes Care
UR  - http://dx.doi.org/10.2337/dc15-1588
UR  - http://hdl.handle.net/10044/1/30529
VL  - 39
ER  -

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