Imperial College London
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DrRuthPeters

Faculty of Medicine, School of Public Health

Honorary Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 8974r.peters

 
 
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Location

 

Stadium HouseWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Yasar:2016:10.1007/s11906-016-0674-1,
author = {Yasar, S and Schuchman, M and Peters, J and Anstey, KJ and Carlson, MC and Peters, R},
doi = {10.1007/s11906-016-0674-1},
journal = {Current Hypertension Reports},
title = {Relationship between antihypertensive medications and cognitive impairment: Part I. review of human studies and clinical trials},
url = {http://dx.doi.org/10.1007/s11906-016-0674-1},
volume = {18},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Purpose of review:There is an established association between hypertension and increased risk of poor cognitive performance and dementia including Alzheimer’s disease; however, associations between antihypertensive medications (AHMs) and dementia risk are less consistent. An increased interest in AHM has resulted in expanding publications; however, none of the recent reviews are comprehensive. Our extensive review includes 15 observational and randomized controlled trials (RCTs) published over the last 5 years, assessing the relationship between AHM and cognitive impairment.Recent findings:All classes of AHM showed similar result patterns in human studies with the majority of study results reporting point estimates below one and only a small number of studies (N = 15) reporting statistically significant results in favor of a specific class.Summary:Only a small number of studies reported statistically significant results in favor of a specific class of AHM. Methodological limitations of the studies prevent definitive conclusions. Further work is now needed to evaluate the class of AHM and cognitive outcomes in future RCTs, with a particular focus on the drugs with the promising results in both animals and human observational studies.
AU  - Yasar,S
AU  - Schuchman,M
AU  - Peters,J
AU  - Anstey,KJ
AU  - Carlson,MC
AU  - Peters,R
DO  - 10.1007/s11906-016-0674-1
PY  - 2016///
SN  - 1534-3111
TI  - Relationship between antihypertensive medications and cognitive impairment: Part I. review of human studies and clinical trials
T2  - Current Hypertension Reports
UR  - http://dx.doi.org/10.1007/s11906-016-0674-1
UR  - http://hdl.handle.net/10044/1/38823
VL  - 18
ER  -
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