Imperial College London
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DrRuiPinto

Faculty of Medicine, School of Public Health

Research Associate in Chemometrics/Metabolomics
 
 
 
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Contact

 

+44 (0)20 7594 9761r.pinto Website

 
 
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Location

 

155Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Boles:2017:10.1016/j.ijcard.2016.11.093,
author = {Boles, U and Pinto, RC and David, S and Abdullah, AS and Henein, MY},
doi = {10.1016/j.ijcard.2016.11.093},
journal = {Int J Cardiol},
pages = {303--308},
title = {Dysregulated fatty acid metabolism in coronary ectasia: An extended lipidomic analysis.},
url = {http://dx.doi.org/10.1016/j.ijcard.2016.11.093},
volume = {228},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Coronary artery ectasia (CAE) is not an uncommon clinical condition, which could be associated with adverse outcome. The exact pathophysiology of the disease is poorly understood and is commonly interpreted as a variant of atherosclerosis. In this study, we sought to undertake lipidomic profiling of a group of CAE patients in an attempt to achieve better understanding of its disturbed metabolism. METHODS: Untargeted lipid profiling and complementary modelling strategies were employed to compare serum samples from 16 patients with CAE (mean age 63.5±10.1years, 6 female) and 26 controls with normal smooth coronary arteries (mean age 59.2±6.6years and 7 female). Sample preparation, LC-MS analysis and metabolite identification were performed at the Swedish Metabolomics Centre, Umeå, Sweden. RESULTS: Phosphatidylcholine levels were significantly distorted in the CAE patients (p=0.001-0.04). Specifically, 16-carbon fatty acyl chain phosphatidylcholines (PC) were detected in lower levels. Similarly, 11 meioties of Sphyngomyelin (SM) species were detected at lower concentrations (p=0.000001-0.01) in the same group. However, only three metabolites were significantly higher in the pure CAE subgroup (6 patients) when compared with the 10 mixed CAE patients (two meioties of SM species and one of PC). Atherosclerosis risk factors were not different between groups. CONCLUSION: This is the first lipid profiling study reported in coronary artery ectasia. While the lower concentration and dysregulation of sphyngomyelin suggests an evidence for premature apoptosis, that of phosphatidylcholines suggests perturbed fatty acid elongation/desaturation, thus may be indicative of non-atherogenic process in CAE.
AU  - Boles,U
AU  - Pinto,RC
AU  - David,S
AU  - Abdullah,AS
AU  - Henein,MY
DO  - 10.1016/j.ijcard.2016.11.093
EP  - 308
PY  - 2017///
SP  - 303
TI  - Dysregulated fatty acid metabolism in coronary ectasia: An extended lipidomic analysis.
T2  - Int J Cardiol
UR  - http://dx.doi.org/10.1016/j.ijcard.2016.11.093
UR  - https://www.ncbi.nlm.nih.gov/pubmed/27866019
VL  - 228
ER  -
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