Imperial College London
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DrRuiPinto

Faculty of Medicine, School of Public Health

Research Associate in Chemometrics/Metabolomics
 
 
 
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Contact

 

+44 (0)20 7594 9761r.pinto Website

 
 
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Location

 

155Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Pazoki:2019:10.1038/s41467-019-11451-y,
author = {Pazoki, R and Evangelou, E and Mosen-Ansorena, D and Pinto, R and Karaman, I and Blakeley, P and Gill, D and Zuber, V and Elliott, P and Tzoulaki, I and Dehghan, A},
doi = {10.1038/s41467-019-11451-y},
journal = {Nature Communications},
title = {GWAS for urinary sodium and potassium excretion highlights pathways shared with cardiovascular traits},
url = {http://dx.doi.org/10.1038/s41467-019-11451-y},
volume = {10},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Urinary sodium and potassium excretion are associated with blood pressure (BP) and cardiovascular disease (CVD). The exact biological link between these traits is yet to be elucidated. Here, we identify 51 loci for sodium and 13 for potassium excretion in a large-scale genome-wide association study (GWAS) on urinary sodium and potassium excretion using data from 446,237 individuals of European descent from the UK Biobank study. We extensively interrogate the results using multiple analyses such as Mendelian randomization, functional assessment, co localization, genetic risk score, and pathway analyses. We identify a shared genetic component between urinary sodium and potassium expression and cardiovascular traits. Ingenuity pathway analysis shows that urinary sodium and potassium excretion loci are over represented in behavioural response to stimuli. Our study highlights pathways that are shared between urinary sodium and potassium excretion and cardiovascular traits.
AU  - Pazoki,R
AU  - Evangelou,E
AU  - Mosen-Ansorena,D
AU  - Pinto,R
AU  - Karaman,I
AU  - Blakeley,P
AU  - Gill,D
AU  - Zuber,V
AU  - Elliott,P
AU  - Tzoulaki,I
AU  - Dehghan,A
DO  - 10.1038/s41467-019-11451-y
PY  - 2019///
SN  - 2041-1723
TI  - GWAS for urinary sodium and potassium excretion highlights pathways shared with cardiovascular traits
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-019-11451-y
UR  - http://hdl.handle.net/10044/1/71729
VL  - 10
ER  -
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