Imperial College London

Professor Richard Reynolds, BSc AKC PhD

Faculty of MedicineDepartment of Medicine

Professor of Cellular Neurobiology
 
 
 
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Contact

 

+44 (0)20 7594 6668r.reynolds

 
 
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Location

 

E414Burlington DanesHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

127 results found

Calabrese M, Castellaro M, Bertoldo A, De Luca A, Pizzini FB, Ricciardi GK, Pitteri M, Zimatore S, Magliozzi R, Benedetti MD, Manganotti P, Montemezzi S, Reynolds R, Gajofatto A, Monaco Set al., 2017, Epilepsy in multiple sclerosis: The role of temporal lobe damage, MULTIPLE SCLEROSIS JOURNAL, Vol: 23, Pages: 473-482, ISSN: 1352-4585

JOURNAL ARTICLE

Castellaro M, Magliozzi R, Palombit A, Pitteri M, Silvestri E, Camera V, Montemezzi S, Pizzini FB, Bertoldo A, Reynolds R, Monaco S, Calabrese Met al., 2017, Heterogeneity of Cortical Lesion Susceptibility Mapping in Multiple Sclerosis, AMERICAN JOURNAL OF NEURORADIOLOGY, Vol: 38, Pages: 1087-1095, ISSN: 0195-6108

JOURNAL ARTICLE

Farina G, Magliozzi R, Pitteri M, Reynolds R, Rossi S, Gajofatto A, Benedetti MD, Facchiano F, Monaco S, Calabrese Met al., 2017, Increased cortical lesion load and intrathecal inflammation is associated with oligoclonal bands in multiple sclerosis patients: a combined CSF and MRI study, JOURNAL OF NEUROINFLAMMATION, Vol: 14, ISSN: 1742-2094

JOURNAL ARTICLE

Raffel J, Wallace A, Gveric D, Reynolds R, Friede T, Nicholas Ret al., 2017, Patient-reported outcomes and survival in multiple sclerosis: A 10-year retrospective cohort study using the Multiple Sclerosis Impact Scale-29, PLOS MEDICINE, Vol: 14, ISSN: 1549-1676

JOURNAL ARTICLE

Bevan R, Griffiths L, Watkins L, Evans R, McInerney B, Rees M, Calabrese M, Magliozzi R, Reynolds R, Allen I, Fitzgerald D, Howell Oet al., 2016, Significant meningeal inflammation and cortical neurodegeneration in a post-mortem cohort of short disease duration multiple sclerosis, 32nd Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS), Publisher: SAGE PUBLICATIONS LTD, Pages: 468-468, ISSN: 1352-4585

CONFERENCE PAPER

James R, Browne E, Mazarakis N, Reynolds Ret al., 2016, Persistent cytokine production induced in the cerebral meninges in a rat model of MS gives rise to chronic cortical pathology., 32nd Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS), Publisher: SAGE PUBLICATIONS LTD, Pages: 27-27, ISSN: 1352-4585

CONFERENCE PAPER

Kesingland A, Browne E, Coello C, Tang SP, Matusiak N, Keat N, Nuesslein-Hildesheim B, Reynolds R, Wells Let al., 2016, TSPO AVAILABILITY IS A ROBUST MEASURE OF SEVERITY IN A RAT MODEL OF MULTIPLE SCLEROSIS, 27th International Symposium on Cerebral Blood Flow, Metabolism and Function / 12th International Conference on Quantification of Brain Function with PET, Publisher: SAGE PUBLICATIONS INC, Pages: 39-40, ISSN: 0271-678X

CONFERENCE PAPER

Matthews PM, Roncaroli F, Waldman A, Sormani MP, De Stefano N, Giovannoni G, Reynolds Ret al., 2016, A practical review of the neuropathology and neuroimaging of multiple sclerosis., Pract Neurol, Vol: 16, Pages: 279-287

The variability in the severity and clinical course of multiple sclerosis (MS) has as its basis an extreme heterogeneity in the location, nature and extent of pathology in the brain and spinal cord. Understanding the underlying neuropathology and associated pathogenetic mechanisms of the disease helps to communicate the rationale for treatment and disease monitoring to patients. Neuroimaging is an important tool for this: it allows clinicians to relate neuropathological changes to clinical presentations and to monitor the course of their disease. Here, we review MS neuropathology and its imaging correlates to provide a practical guide for using MRI to assess disease severity and treatment responses. This provides a foundation for optimal management of patients based on the principle that they show 'no evidence of disease activity'.

JOURNAL ARTICLE

Nicholas R, Magliozzi R, Campbell G, Mahad D, Reynolds Ret al., 2016, Temporal lobe cortical pathology and inhibitory GABA interneuron cell loss are associated with seizures in multiple sclerosis, MULTIPLE SCLEROSIS JOURNAL, Vol: 22, Pages: 25-35, ISSN: 1352-4585

JOURNAL ARTICLE

Sellebjerg F, Cadavid D, Steiner D, Maria Villar L, Reynolds R, Mikol Det al., 2016, Exploring potential mechanisms of action of natalizumab in secondary progressive multiple sclerosis, THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS, Vol: 9, Pages: 31-43, ISSN: 1756-2856

JOURNAL ARTICLE

Wallace A, Raffel J, Reynolds R, Friede T, Nicholas Ret al., 2016, Increased multiple sclerosis impact scale-29 score is associated with reduced survival in multiple sclerosis, 32nd Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS), Publisher: SAGE PUBLICATIONS LTD, Pages: 455-456, ISSN: 1352-4585

CONFERENCE PAPER

Watkins LM, Neal JW, Loveless S, Michailidou I, Ramaglia V, Rees MI, Reynolds R, Robertson NP, Morgan BP, Howell OWet al., 2016, Complement is activated in progressive multiple sclerosis cortical grey matter lesions, JOURNAL OF NEUROINFLAMMATION, Vol: 13, ISSN: 1742-2094

JOURNAL ARTICLE

Calabrese M, Magliozzi R, Ciccarelli O, Geurts JJG, Reynolds R, Martin Ret al., 2015, Exploring the origins of grey matter damage in multiple sclerosis, NATURE REVIEWS NEUROSCIENCE, Vol: 16, Pages: 147-158, ISSN: 1471-003X

JOURNAL ARTICLE

Calabrese M, Reynolds R, Magliozzi R, Castellaro M, Morra A, Scalfari A, Farina G, Romualdi C, Gajofatto A, Pitteri M, Benedetti MD, Monaco Set al., 2015, Regional Distribution and Evolution of Gray Matter Damage in Different Populations of Multiple Sclerosis Patients, PLOS ONE, Vol: 10, ISSN: 1932-6203

JOURNAL ARTICLE

Durrenberger PF, Fernando FS, Kashefi SN, Bonnert TP, Seilhean D, Nait-Oumesmar B, Schmitt A, Gebicke-Haerter PJ, Falkai P, Gruenblatt E, Palkovits M, Arzberger T, Kretzschmar H, Dexter DT, Reynolds Ret al., 2015, Common mechanisms in neurodegeneration and neuroinflammation: a BrainNet Europe gene expression microarray study, JOURNAL OF NEURAL TRANSMISSION, Vol: 122, Pages: 1055-1068, ISSN: 0300-9564

JOURNAL ARTICLE

Gautier HOB, Evans KA, Volbracht K, James R, Sitnikov S, Lundgaard I, James F, Lao-Peregrin C, Reynolds R, Franklin RJM, Karadottir RTet al., 2015, Neuronal activity regulates remyelination via glutamate signalling to oligodendrocyte progenitors, NATURE COMMUNICATIONS, Vol: 6, ISSN: 2041-1723

JOURNAL ARTICLE

Giannetti P, Politis M, Su P, Turkheimer FE, Malik O, Keihaninejad S, Wu K, Waldman A, Reynolds R, Nicholas R, Piccini Pet al., 2015, Increased PK11195-PET binding in normal-appearing white matter in clinically isolated syndrome, BRAIN, Vol: 138, Pages: 110-119, ISSN: 0006-8950

JOURNAL ARTICLE

Zhang A, Desmazieres A, Zonta B, Melrose S, Campbell G, Mahad D, Li Q, Sherman DL, Reynolds R, Brophy PJet al., 2015, Neurofascin 140 Is an Embryonic Neuronal Neurofascin Isoform That Promotes the Assembly of the Node of Ranvier, JOURNAL OF NEUROSCIENCE, Vol: 35, Pages: 2246-2254, ISSN: 0270-6474

JOURNAL ARTICLE

Giannetti P, Politis M, Su P, Turkheimer F, Malik O, Keihaninejad S, Wu K, Reynolds R, Nicholas R, Piccini Pet al., 2014, Microglia activation in multiple sclerosis black holes predicts outcome in progressive patients: An in vivo [(11)C](R)-PK11195-PET pilot study, NEUROBIOLOGY OF DISEASE, Vol: 65, Pages: 203-210, ISSN: 0969-9961

JOURNAL ARTICLE

Lieury A, Chanal M, Androdias G, Reynolds R, Cavagna S, Giraudon P, Confavreux C, Nataf Set al., 2014, Tissue Remodeling in Periplaque Regions of Multiple Sclerosis Spinal Cord Lesions, GLIA, Vol: 62, Pages: 1645-1658, ISSN: 0894-1491

JOURNAL ARTICLE

Markoullis K, Sargiannidou I, Schiza N, Roncaroli F, Reynolds R, Kleopa KAet al., 2014, Oligodendrocyte Gap Junction Loss and Disconnection From Reactive Astrocytes in Multiple Sclerosis Gray Matter, JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, Vol: 73, Pages: 865-879, ISSN: 0022-3069

JOURNAL ARTICLE

Schirmer L, Srivastava R, Kalluri SR, Boettinger S, Herwerth M, Carassiti D, Srivastava B, Gempt J, Schlegel J, Kuhlmann T, Korn T, Reynolds R, Hemmer Bet al., 2014, Differential Loss of KIR4.1 Immunoreactivity in Multiple Sclerosis Lesions, ANNALS OF NEUROLOGY, Vol: 75, Pages: 810-828, ISSN: 0364-5134

JOURNAL ARTICLE

Sellmann C, Pildain LV, Schmitt A, Leonardi-Essmann F, Durrenberger PF, Spanagel R, Arzberger T, Kretzschmar H, Zink M, Gruber O, Herrera-Marschitz M, Reynolds R, Falkai P, Gebicke-Haerter PJ, Matthaeus Fet al., 2014, Gene expression in superior temporal cortex of schizophrenia patients, EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, Vol: 264, Pages: 297-309, ISSN: 0940-1334

JOURNAL ARTICLE

Abrahamsson SV, Angelini DF, Dubinsky AN, Morel E, Oh U, Jones JL, Carassiti D, Reynolds R, Salvetti M, Calabresi PA, Coles AJ, Battistini L, Martin R, Burt RK, Muraro PAet al., 2013, Non-myeloablative autologous haematopoietic stem cell transplantation expands regulatory cells and depletes IL-17 producing mucosal-associated invariant T cells in multiple sclerosis, BRAIN, Vol: 136, Pages: 2888-2903, ISSN: 0006-8950

JOURNAL ARTICLE

Campbell GR, Reeve A, Ziabreva I, Polvikoski TM, Taylor RW, Reynolds R, Turnbull DM, Mahad DJet al., 2013, Mitochondrial DNA deletions and depletion within paraspinal muscles, NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, Vol: 39, Pages: 377-389, ISSN: 0305-1846

JOURNAL ARTICLE

Campbell GR, Reeve AK, Ziabreva I, Reynolds R, Turnbull DM, Mahad DJet al., 2013, No excess of mitochondrial DNA deletions within muscle in progressive multiple sclerosis, MULTIPLE SCLEROSIS JOURNAL, Vol: 19, Pages: 1858-1866, ISSN: 1352-4585

JOURNAL ARTICLE

Gardner C, Magliozzi R, Durrenberger PF, Howell OW, Rundle J, Reynolds Ret al., 2013, Cortical grey matter demyelination can be induced by elevated pro-inflammatory cytokines in the subarachnoid space of MOG-immunized rats, BRAIN, Vol: 136, Pages: 3596-3608, ISSN: 0006-8950

JOURNAL ARTICLE

Kalk NJ, Owen DR, Tyacke RJ, Reynolds R, Rabiner EA, Lingford-hughes AR, Parker CAet al., 2013, Are Prescribed Benzodiazepines Likely to Affect the Availability of the 18 kDa Translocator Protein (TSPO) in PET Studies?, SYNAPSE, Vol: 67, Pages: 909-912, ISSN: 0887-4476

JOURNAL ARTICLE

Magliozzi R, Serafini B, Rosicarelli B, Chiappetta G, Veroni C, Reynolds R, Aloisi Fet al., 2013, B-Cell Enrichment and Epstein-Barr Virus Infection in Inflammatory Cortical Lesions in Secondary Progressive Multiple Sclerosis, JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, Vol: 72, Pages: 29-41, ISSN: 0022-3069

JOURNAL ARTICLE

Mathew A, Pakan JMP, Collin EC, Wang W, McDermott KW, Fitzgerald U, Reynolds R, Pandit ASet al., 2013, An ex-vivo multiple sclerosis model of inflammatory demyelination using hyperbranched polymer, BIOMATERIALS, Vol: 34, Pages: 5872-5882, ISSN: 0142-9612

JOURNAL ARTICLE

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