Imperial College London
Alternate

Professor Richard Reynolds, BSc AKC PhD

Faculty of Medicine, Department of Brain Sciences

Professor of Cellular Neurobiology
 
 
 
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Contact

 

+44 (0)20 7594 6668r.reynolds

 
 
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Location

 

E414Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Calabrese:2015:10.1371/journal.pone.0135428,
author = {Calabrese, M and Reynolds, R and Magliozzi, R and Castellaro, M and Morra, A and Scalfari, A and Farina, G and Romualdi, C and Gajofatto, A and Pitteri, M and Benedetti, MD and Monaco, S},
doi = {10.1371/journal.pone.0135428},
journal = {PLOS One},
title = {Regional distribution and evolution of gray matter damage in different populations of multiple sclerosis patients},
url = {http://dx.doi.org/10.1371/journal.pone.0135428},
volume = {10},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundBoth gray-matter (GM) atrophy and lesions occur from the earliest stages of Multiple Sclerosis (MS) and are one of the major determinants of long-term clinical outcomes. Nevertheless, the relationship between focal and diffuse GM damage has not been clarified yet. Here we investigate the regional distribution and temporal evolution of cortical thinning and how it is influenced by the local appearance of new GM lesions at different stages of the disease in different populations of MS patients.MethodsWe studied twenty MS patients with clinically isolated syndrome (CIS), 27 with early relapsing-remitting MS (RRMS, disease duration <5 years), 29 with late RRMS (disease duration ≥ 5 years) and 20 with secondary-progressive MS (SPMS). The distribution and evolution of regional cortical thickness and GM lesions were assessed during 5-year follow-up.ResultsThe results showed that new lesions appeared more frequently in hippocampus and parahippocampal gyri (9.1%), insula (8.9%), cingulate cortex (8.3%), superior frontal gyrus (8.1%), and cerebellum (6.5%). The aforementioned regions showed the greatest reduction in thickness/volume, although (several) differences were observed across subgroups. The correlation between the appearance of new cortical lesions and cortical thinning was stronger in CIS (r2 = 50.0, p<0.001) and in early RRMS (r2 = 52.3, p<0.001), compared to late RRMS (r2 = 25.5, p<0.001) and SPMS (r2 = 6.3, p = 0.133).ConclusionsWe conclude that GM atrophy and lesions appear to be different signatures of cortical disease in MS having in common overlapping spatio-temporal distribution patterns. However, the correlation between focal and diffuse damage is only moderate and more evident in the early phase of the disease.
AU  - Calabrese,M
AU  - Reynolds,R
AU  - Magliozzi,R
AU  - Castellaro,M
AU  - Morra,A
AU  - Scalfari,A
AU  - Farina,G
AU  - Romualdi,C
AU  - Gajofatto,A
AU  - Pitteri,M
AU  - Benedetti,MD
AU  - Monaco,S
DO  - 10.1371/journal.pone.0135428
PY  - 2015///
SN  - 1932-6203
TI  - Regional distribution and evolution of gray matter damage in different populations of multiple sclerosis patients
T2  - PLOS One
UR  - http://dx.doi.org/10.1371/journal.pone.0135428
UR  - http://hdl.handle.net/10044/1/30917
VL  - 10
ER  -
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