Professor Robin Shattock is the Head of Mucosal Infection and Immunity within the Department of Medicine at Imperial College London. Professor Shattock’s research focuses on the mechanisms of mucosal infection and the development of novel preventative strategies appropriate to a developing world setting. This has led to the establishment of international collaborations aimed at preclinical identification, development and selection of HIV microbicide and vaccine candidates prior to formal clinical efficacy trials.
Professor Shattock oversees a portfolio of research that is supported by 26 members of staff including researchers, PhD students, clinical trial managers and project managers. Professor Shattock has published over 160 peer reviewed articles in this area and secured funding from the European Commission, Bill and Melinda Gates Foundation, Wellcome Trust, MRC and the NIH.
DNAVAC is funded by the Gates Foundation as part of the Collaboration for AIDS Vaccine Discovery (CAVD). Prof Shattock’s group is responsible for the DNAVAC project (https://www.cavd.org/grantees/Pages/Grantee-Shattock.aspx) which aims to apply recent state of the art technological advances in DNA vaccination and immune monitoring, both at the single cell and molecular level, to enable detailed probing of developing vaccine induced antibody responses.
ADITEC (Advanced Immunisation Technologies: http://www.aditecproject.eu) is funded under the 7th Framework by the EU. ADITEC is a collaborative research programme with 42 partners from 13 EU countries that aims to accelerate the development of novel and powerful immunisation technologies for the next generation of human vaccines. Professor Shattock leads the Prime-boost workpackage for the consortium.
BioVacSafe (Biomarkers for enhanced vaccines immunosafety - http://www.biovacsafe.eu) is a 5 years project funded by EU Innovative Medicine initiative (IMI). BioVacSafe aims to develop cutting edge tools to speed up and improve the testing and monitoring of vaccine safety, both before and after release to the market. It is a public private consortium of 19 partners involving three of Europe's leading vaccine producing companies, experts from major academic institutions, small and medium-sized enterprises (SMEs) and non-governmental organization (NGO): http://www.biovacsafe.eu/#sthash.UN2RSrBe.dpuf. Professor Shattock leads the work package on preclinical models.
The EAVI2020 consortium, funded under H2020 by the EU, is led by Prof Shattock at Imperial College London, and brings together leading HIV researchers from 23 public organisations and biotech companies from across Europe, Australia, Canada and the USA, pooling their knowledge and expertise to develop novel candidate vaccines that can be taken through to human trials within five years. http://www.eavi2020.eu. In addition to coordinating the programme, Prof Shattock’s group is responsible for performing a range of Experimental Medicine clinical trials of promising new HIV candidates.
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et al., 2017, Flow virometry analysis of envelope glycoprotein conformations on individual HIV virions, Scientific Reports, Vol:7, ISSN:2045-2322
et al., 2017, Expressing anti-HIV VRC01 antibody using the murine IgG1 secretion signal in Pichia pastoris, Amb Express, Vol:7, ISSN:2191-0855
et al., 2017, Broadly Neutralizing Antibodies Display Potential for Prevention of HIV-1 Infection of Mucosal Tissue Superior to That of Nonneutralizing Antibodies, Journal of Virology, Vol:91, ISSN:0022-538X
et al., 2017, The synergistic effects of combining TLR ligand based adjuvants on the cytokine response are dependent upon p38/JNK signalling., Cytokine
et al., 2017, A Comparative Phase I Study of Combination, Homologous Subtype-C DNA, MVA, and Env gp140 Protein/Adjuvant HIV Vaccines in Two Immunization Regimes, Frontiers in Immunology, Vol:8, ISSN:1664-3224