Imperial College London

ProfessorRobinShattock

Faculty of MedicineDepartment of Infectious Disease

Chair in Mucosal Infection and Immunity
 
 
 
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Contact

 

+44 (0)20 7594 5206r.shattock

 
 
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Location

 

453Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

286 results found

Friedland JS, Hartley JC, Hartley CGC, Shattock RJ, Griffin GEet al., 1996, Cytokine secretion in vivo and ex vivo following chemotherapy of Mycobacterium tuberculosis infection, TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, Vol: 90, Pages: 199-203, ISSN: 0035-9203

Journal article

Shattock RJ, Burger D, Dayer JM, Griffin GEet al., 1996, Enhanced HIV replication in monocytic cells following engagement of adhesion molecules and contact with stimulated T cells, RESEARCH IN VIROLOGY, Vol: 147, Pages: 171-179, ISSN: 0923-2516

Journal article

Shattock RJ, Griffin GE, 1996, Mucosal Transmission of Human Immunodeficiency Virus, The molecular biology of HIV/AIDS, Editors: Lever, Publisher: John Wiley & Son Ltd, Pages: 25-38, ISBN: 9780471960942

Book chapter

FRIEDLAND JS, HARTLEY JC, HARTLEY CGC, SHATTOCK RJ, GRIFFIN GEet al., 1995, INHIBITION OF EX-VIVO PROINFLAMMATORY CYTOKINE SECRETION IN FATAL MYCOBACTERIUM-TUBERCULOSIS INFECTION, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 100, Pages: 233-238, ISSN: 0009-9104

Journal article

BUTERA ST, SHATTOCK RJ, ROBERTS BD, FREIMUTH W, BOXER L, GRIFFIN GE, FOLKS TM, NABEL GJet al., 1995, SIGNALING VIA ENGAGEMENT OF SURFACE LFA-1 STIMULATES REPLICATION OF HIV-1, AIDS RESEARCH AND HUMAN RETROVIRUSES, Vol: 11, Pages: S118-S118, ISSN: 0889-2229

Journal article

PALACIO J, SOUBERBIELLE BE, SHATTOCK RJ, ROBINSON G, MANYONDA I, GRIFFIN GEet al., 1994, IN-VITRO HIV-1 INFECTION OF HUMAN CERVICAL TISSUE, RESEARCH IN VIROLOGY, Vol: 145, Pages: 155-161, ISSN: 0923-2516

Journal article

SHATTOCK RJ, GRIFFIN GE, 1994, CELLULAR ADHERENCE ENHANCES HIV REPLICATION IN MONOCYTIC CELLS, RESEARCH IN VIROLOGY, Vol: 145, Pages: 139-145, ISSN: 0923-2516

Journal article

SHATTOCK RJ, FRIEDLAND JS, GRIFFIN GE, 1994, PHAGOCYTOSIS OF MYCOBACTERIUM-TUBERCULOSIS MODULATES HUMAN-IMMUNODEFICIENCY-VIRUS REPLICATION IN HUMAN MONOCYTIC CELLS, JOURNAL OF GENERAL VIROLOGY, Vol: 75, Pages: 849-856, ISSN: 0022-1317

Journal article

Shattock RJ, Friedland JS, Griffin GE, 1994, Phagocytosis of Mycobacterium tuberculosis modulates human immunodeficiency virus replication in human monocytic cells., J Gen Virol, Vol: 75 ( Pt 4), Pages: 849-856, ISSN: 0022-1317

Macrophage activation resulting from phagocytosis has the potential to modulate human immunodeficiency virus (HIV) replication. We have determined the effects of phagocytosis of particulate stimuli on transcription and release of HIV. Using THP-1 and Mono Mac 6 human monocytic cell lines transfected with HIV long terminal repeat sequence chloramphenicol acetyltransferase (LTR CAT) constructs we have demonstrated that phagocytosis of Mycobacterium tuberculosis enhanced HIV-1 and -2 LTR CAT expression. However phagocytosis of zymosan or inert latex beads had little or no effect on CAT expression. Enhancement of HIV LTR CAT expression was dependent upon intact NF-kappa B binding sites and was independent of tumour necrosis factor alpha secretion. M. tuberculosis strains of different degrees of virulence induced similar levels of enhanced CAT expression. In contrast, phagocytosis of M. tuberculosis by HIV-1-infected THP-1 cells reduced supernatant reverse transcriptase (RT) activity without suppression of p24 antigen release. Phagocytosis of zymosan granules or latex particles did not alter released RT activity. However, phagocytosis of either M. tuberculosis, zymosan granules or latex particles by HIV-1-infected human peripheral blood monocyte-derived macrophages reduced supernatant RT activity. These data indicate that phagocytosis of M. tuberculosis may enhance HIV transcription in monocytic cells although it may reduce release of intact HIV.

Journal article

SHATTOCK RJ, FRIEDLAND JS, GRIFFIN GE, 1993, RELEASE OF HUMAN-IMMUNODEFICIENCY-VIRUS BY THP-1 CELLS AND HUMAN MACROPHAGES IS REGULATED BY CELLULAR ADHERENCE AND ACTIVATION, JOURNAL OF VIROLOGY, Vol: 67, Pages: 3569-3575, ISSN: 0022-538X

Journal article

FRIEDLAND JS, SHATTOCK RJ, GRIFFIN GE, 1993, PHAGOCYTOSIS OF MYCOBACTERIUM-TUBERCULOSIS OR PARTICULATE STIMULI BY HUMAN MONOCYTIC CELLS INDUCES EQUIVALENT MONOCYTE CHEMOTACTIC PROTEIN-1 GENE-EXPRESSION, CYTOKINE, Vol: 5, Pages: 150-156, ISSN: 1043-4666

Journal article

FRIEDLAND JS, SHATTOCK RJ, JOHNSON JD, REMICK DG, HOLLIMAN RE, GRIFFIN GEet al., 1993, DIFFERENTIAL CYTOKINE GENE-EXPRESSION AND SECRETION AFTER PHAGOCYTOSIS BY A HUMAN MONOCYTIC CELL-LINE OF TOXOPLASMA-GONDII COMPARED WITH MYCOBACTERIUM-TUBERCULOSIS, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 91, Pages: 282-286, ISSN: 0009-9104

Journal article

FRIEDLAND JS, SHATTOCK R, REMICK DG, GRIFFIN GEet al., 1993, MYCOBACTERIAL 65-KD HEAT-SHOCK PROTEIN INDUCES RELEASE OF PROINFLAMMATORY CYTOKINES FROM HUMAN MONOCYTIC CELLS, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 91, Pages: 58-62, ISSN: 0009-9104

Journal article

SHATTOCK RJ, FRIEDLAND JS, GRIFFIN GE, 1993, MODULATION OF HIV TRANSCRIPTION IN AND RELEASE FROM HUMAN MONOCYTIC CELLS FOLLOWING PHAGOCYTOSIS OF MYCOBACTERIUM-TUBERCULOSIS, RESEARCH IN VIROLOGY, Vol: 144, Pages: 7-12, ISSN: 0923-2516

Journal article

FRIEDLAND JS, REMICK DG, SHATTOCK R, GRIFFIN GEet al., 1992, SECRETION OF INTERLEUKIN-8 FOLLOWING PHAGOCYTOSIS OF MYCOBACTERIUM-TUBERCULOSIS BY HUMAN MONOCYTE CELL-LINES, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 22, Pages: 1373-1378, ISSN: 0014-2980

Journal article

SHATTOCK RJ, 1990, DEVELOPMENT OF A GENE PROBE ASSAY SUITABLE FOR USE IN ROUTINE DIAGNOSIS - A PILOT-STUDY USING A DNA PROBE FOR PARVOVIRUS B19, MEDICAL LABORATORY SCIENCES, Vol: 47, Pages: 97-102, ISSN: 0308-3616

Journal article

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