Imperial College London

ProfessorRobinShattock

Faculty of MedicineDepartment of Infectious Disease

Chair in Mucosal Infection and Immunity
 
 
 
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Contact

 

+44 (0)20 7594 5206r.shattock

 
 
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Location

 

453Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

275 results found

Veazey RS, Shattock RJ, Pope M, Kirijan JC, Jones J, Hu QX, Ketas T, Marx PA, Klasse PJ, Burton DR, Moore JPet al., 2003, Prevention of virus transmission to macaque monkeys by a vaginally applied monoclonal antibody to HIV-1 gp120, NATURE MEDICINE, Vol: 9, Pages: 343-346, ISSN: 1078-8956

Journal article

Miller CJ, Shattock RJ, 2003, Target cells in vaginal HIV transmission, MICROBES AND INFECTION, Vol: 5, Pages: 59-67, ISSN: 1286-4579

Journal article

Shattock RJ, Doms RW, 2002, AIDS models: Microbicides could learn from vaccines, NATURE MEDICINE, Vol: 8, Pages: 425-425, ISSN: 1078-8956

Journal article

MacDougall THJ, Shattock RJ, Madsen C, Chain BM, Katz DRet al., 2002, Regulation of primary HIV-1 isolate replication in dendritic cells, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 127, Pages: 66-71, ISSN: 0009-9104

Journal article

Warwick-Davies J, Watson AJ, Griffin GE, Krishna S, Shattock RJet al., 2001, Enhancement of Mycobacterium tuberculosis-induced tumor necrosis factor alpha production from primary human monocytes by an activated T-cell membrane-mediated mechanism, INFECTION AND IMMUNITY, Vol: 69, Pages: 6580-6587, ISSN: 0019-9567

Journal article

Shattock RJ, 2001, HIV infection of human cervical tissue in vitro and the effects of vaginal virucides, AIDS, Vol: 15, Pages: S39-S39, ISSN: 0269-9370

Journal article

Sampaio EP, Oliveira RB, Warwick-Davies J, Neto RBF, Griffin GE, Shattock RJet al., 2000, T cell-monocyte contact enhances tumor necrosis factor-alpha production in response to Mycobacterium leprae, JOURNAL OF INFECTIOUS DISEASES, Vol: 182, Pages: 1463-1472, ISSN: 0022-1899

Journal article

Greenhead P, Hayes P, Watts PS, Laing KG, Griffin GE, Shattock RJet al., 2000, Parameters of human immunodeficiency virus infection of human cervical tissue and inhibition by vaginal virucides, JOURNAL OF VIROLOGY, Vol: 74, Pages: 5577-5586, ISSN: 0022-538X

Journal article

Shattock RJ, Griffin GE, Gorodeski GI, 2000, In vitro models of mucosal HIV transmission, NATURE MEDICINE, Vol: 6, Pages: 607-607, ISSN: 1078-8956

Journal article

Borghi MO, Panzeri P, Shattock R, Sozzani S, Dobrina A, Meroni PLet al., 2000, Interaction between chronically HIV-infected promonocytic cells and human umbilical vein endothelial cells: role of proinflammatory cytokines and chemokines in viral expression modulation., Clin Exp Immunol, Vol: 120, Pages: 93-100, ISSN: 0009-9104

HIV type 1 expression was significantly up-regulated in chronically infected promonocytic cell line (U1) co-cultured with human umbilical vein endothelial cells (HUVEC). Virus replication, evaluated as supernatant p24 release, was higher when U1 were co-cultured with IL-1beta-activated HUVEC than with unstimulated HUVEC. When non-adherent U1 were removed from co-cultures, the remaining U1 cells adherent to the endothelial monolayer still showed enhanced HIV replication in comparison with an equal number of U1 cultured alone. While addition of adhesion molecule blocking antibodies (anti-intercellular adhesion molecule-1 (ICAM-1), -vascular cell adhesion molecule-1 (VCAM-1), -CD18 and -very late antigen-4 (VLA-4)) strongly inhibited adherence of U1 cells to endothelial monolayers, such treatment resulted in only a partial reduction in p24 release. Furthermore, HIV replication in U1 cells was enhanced on culture in HUVEC-conditioned media. Such data suggest that soluble mediators secreted by endothelial monolayers may modulate HIV-1 expression. Indeed, addition of cytokine and chemokine antagonists to both U1/HUVEC co-cultures and to U1 cultured in HUVEC-conditioned media clearly down-regulated p24 release. Anti-IL-6, anti-tumour necrosis factor-alpha (TNF-alpha) and, particularly, anti-MCP-1 MoAbs reduced p24 release, while anti-IL-8 polyclonal antiserum and IL-1 receptor antagonist (IL-1Ra) had no significant effect. Thus, the interaction between HUVEC and infected monocytic cells up-regulates HIV-1 replication predominantly through production of endothelium-derived soluble factors including MCP-1, TNF-alpha and IL-6. This phenomenon may influence the passage of HIV-1 from latency to productive replication and enhance virus spreading during physiological and/or pathological contact of monocytes with endothelium.

Journal article

Greenhead P, Hayes P, Watts PS, Laing KG, Griffin GE, Shattock RJet al., 2000, Parameters of human immunodeficiency virus infection of human cervical tissue and inhibition by vaginal virucides, Vol: 74, Pages: 5577-5586, ISSN: 0022-538X

Journal article

Lawn SD, Shattock RJ, Acheampong JW, Lal RB, Folks TM, Griffin GE, Butera STet al., 1999, Sustained plasma TNF-alpha and HIV-1 load despite resolution of other parameters of immune activation during treatment of tuberculosis in Africans, AIDS, Vol: 13, Pages: 2231-2237, ISSN: 0269-9370

Journal article

Ortigao-deo-Sampaio MB, Shattock RJ, Hayes P, Griffin GE, Linhares-de-Carvalho MI, de Leon AP, Lewis DJM, Castello-Branco RRet al., 1998, Increase in plasma viral load after oral cholera immunization of HIV-infected subjects, AIDS, Vol: 12, Pages: F145-F150, ISSN: 0269-9370

Journal article

Gill V, Shattock RJ, Scopes J, Hayes P, Freedman AR, Griffin GE, GordonSmith EC, Gibson FMet al., 1997, Human immunodeficiency virus infection impairs hemopoiesis in long-term bone marrow cultures: Nonreversal by nucleoside analogues, JOURNAL OF INFECTIOUS DISEASES, Vol: 176, Pages: 1510-1516, ISSN: 0022-1899

Journal article

Lawn SD, Shattock RJ, Griffin GE, 1997, Delays in the diagnosis of tuberculosis: a great new cost, INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, Vol: 1, Pages: 485-486, ISSN: 1027-3719

Journal article

Shattock RJ, Rizzardi GP, Hayes P, Griffin GEet al., 1996, Engagemgnt of adhesion molecules (CD18, CD11a, CD45, CD44, and CD58) enhances human immunodeficiency virus type 1 replication in monocytic cells through a tumor necrosis factor-modulated pathway, JOURNAL OF INFECTIOUS DISEASES, Vol: 174, Pages: 54-62, ISSN: 0022-1899

Journal article

Barcellini W, Rizzardi GP, Marriott JB, Fain C, Shattock RJ, Meroni PL, Poli G, Dalgleish AGet al., 1996, Interleukin-10-induced HIV-1 expression is mediated by induction of both membrane-bound tumour necrosis factor (TNF)-alpha and TNF receptor type 1 in a promonocytic cell line, AIDS, Vol: 10, Pages: 835-842, ISSN: 0269-9370

Journal article

Griffin GE, Castello-Branco LR, Ortig√£o-de-Sampaio MB, Shattock Ret al., 1996, Mucosal immunology and models of mucosal HIV infection., Mem Inst Oswaldo Cruz, Vol: 91, Pages: 367-369, ISSN: 0074-0276

The mucosa associated lymphoid tissue regulates and coordinates immune responses against mucosal pathogens. Mucosal tissues are the major targets exposed to HIV during transmission. In this paper we describe in vitro models of HIV mucosal infection using human explants to investigate target cells within this tissue.

Journal article

Gill V, Shattock RJ, Freedman AR, Robinson G, Griffin GE, GordonSmith EC, Gibson FMet al., 1996, Macrophages are the major target cell for HIV infection in long-term bone marrow culture and demonstrate dual susceptibility to lymphocytotropic and monocytotropic strains of HIV-1, BRITISH JOURNAL OF HAEMATOLOGY, Vol: 93, Pages: 30-37, ISSN: 0007-1048

Journal article

Friedland JS, Hartley JC, Hartley CGC, Shattock RJ, Griffin GEet al., 1996, Cytokine secretion in vivo and ex vivo following chemotherapy of Mycobacterium tuberculosis infection, TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, Vol: 90, Pages: 199-203, ISSN: 0035-9203

Journal article

Shattock RJ, Burger D, Dayer JM, Griffin GEet al., 1996, Enhanced HIV replication in monocytic cells following engagement of adhesion molecules and contact with stimulated T cells, RESEARCH IN VIROLOGY, Vol: 147, Pages: 171-179, ISSN: 0923-2516

Journal article

Shattock RJ, Griffin GE, 1996, Mucosal Transmission of Human Immunodeficiency Virus, The molecular biology of HIV/AIDS, Editors: Lever, Publisher: John Wiley & Son Ltd, Pages: 25-38, ISBN: 9780471960942

Book chapter

FRIEDLAND JS, HARTLEY JC, HARTLEY CGC, SHATTOCK RJ, GRIFFIN GEet al., 1995, INHIBITION OF EX-VIVO PROINFLAMMATORY CYTOKINE SECRETION IN FATAL MYCOBACTERIUM-TUBERCULOSIS INFECTION, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 100, Pages: 233-238, ISSN: 0009-9104

Journal article

BUTERA ST, SHATTOCK RJ, ROBERTS BD, FREIMUTH W, BOXER L, GRIFFIN GE, FOLKS TM, NABEL GJet al., 1995, SIGNALING VIA ENGAGEMENT OF SURFACE LFA-1 STIMULATES REPLICATION OF HIV-1, AIDS RESEARCH AND HUMAN RETROVIRUSES, Vol: 11, Pages: S118-S118, ISSN: 0889-2229

Journal article

PALACIO J, SOUBERBIELLE BE, SHATTOCK RJ, ROBINSON G, MANYONDA I, GRIFFIN GEet al., 1994, IN-VITRO HIV-1 INFECTION OF HUMAN CERVICAL TISSUE, RESEARCH IN VIROLOGY, Vol: 145, Pages: 155-161, ISSN: 0923-2516

Journal article

SHATTOCK RJ, GRIFFIN GE, 1994, CELLULAR ADHERENCE ENHANCES HIV REPLICATION IN MONOCYTIC CELLS, RESEARCH IN VIROLOGY, Vol: 145, Pages: 139-145, ISSN: 0923-2516

Journal article

SHATTOCK RJ, FRIEDLAND JS, GRIFFIN GE, 1994, PHAGOCYTOSIS OF MYCOBACTERIUM-TUBERCULOSIS MODULATES HUMAN-IMMUNODEFICIENCY-VIRUS REPLICATION IN HUMAN MONOCYTIC CELLS, JOURNAL OF GENERAL VIROLOGY, Vol: 75, Pages: 849-856, ISSN: 0022-1317

Journal article

Shattock RJ, Friedland JS, Griffin GE, 1994, Phagocytosis of Mycobacterium tuberculosis modulates human immunodeficiency virus replication in human monocytic cells., J Gen Virol, Vol: 75 ( Pt 4), Pages: 849-856, ISSN: 0022-1317

Macrophage activation resulting from phagocytosis has the potential to modulate human immunodeficiency virus (HIV) replication. We have determined the effects of phagocytosis of particulate stimuli on transcription and release of HIV. Using THP-1 and Mono Mac 6 human monocytic cell lines transfected with HIV long terminal repeat sequence chloramphenicol acetyltransferase (LTR CAT) constructs we have demonstrated that phagocytosis of Mycobacterium tuberculosis enhanced HIV-1 and -2 LTR CAT expression. However phagocytosis of zymosan or inert latex beads had little or no effect on CAT expression. Enhancement of HIV LTR CAT expression was dependent upon intact NF-kappa B binding sites and was independent of tumour necrosis factor alpha secretion. M. tuberculosis strains of different degrees of virulence induced similar levels of enhanced CAT expression. In contrast, phagocytosis of M. tuberculosis by HIV-1-infected THP-1 cells reduced supernatant reverse transcriptase (RT) activity without suppression of p24 antigen release. Phagocytosis of zymosan granules or latex particles did not alter released RT activity. However, phagocytosis of either M. tuberculosis, zymosan granules or latex particles by HIV-1-infected human peripheral blood monocyte-derived macrophages reduced supernatant RT activity. These data indicate that phagocytosis of M. tuberculosis may enhance HIV transcription in monocytic cells although it may reduce release of intact HIV.

Journal article

SHATTOCK RJ, FRIEDLAND JS, GRIFFIN GE, 1993, RELEASE OF HUMAN-IMMUNODEFICIENCY-VIRUS BY THP-1 CELLS AND HUMAN MACROPHAGES IS REGULATED BY CELLULAR ADHERENCE AND ACTIVATION, JOURNAL OF VIROLOGY, Vol: 67, Pages: 3569-3575, ISSN: 0022-538X

Journal article

FRIEDLAND JS, SHATTOCK RJ, GRIFFIN GE, 1993, PHAGOCYTOSIS OF MYCOBACTERIUM-TUBERCULOSIS OR PARTICULATE STIMULI BY HUMAN MONOCYTIC CELLS INDUCES EQUIVALENT MONOCYTE CHEMOTACTIC PROTEIN-1 GENE-EXPRESSION, CYTOKINE, Vol: 5, Pages: 150-156, ISSN: 1043-4666

Journal article

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