Summary
Professor Robin Shattock is the Head of Mucosal Infection and Immunity within the Department of Medicine at Imperial College London. Professor Shattock’s research focuses on the mechanisms of mucosal infection and the development of novel preventative strategies appropriate to a developing world setting. This has led to the establishment of international collaborations aimed at preclinical identification, development and selection of HIV microbicide and vaccine candidates prior to formal clinical efficacy trials.
Professor Shattock oversees a portfolio of research that is supported by 26 members of staff including researchers, PhD students, clinical trial managers and project managers. Professor Shattock has published over 160 peer reviewed articles in this area and secured funding from the European Commission, Bill and Melinda Gates Foundation, Wellcome Trust, MRC and the NIH.
DNAVAC is funded by the Gates Foundation as part of the Collaboration for AIDS Vaccine Discovery (CAVD). Prof Shattock’s group is responsible for the DNAVAC project (https://www.cavd.org/grantees/Pages/Grantee-Shattock.aspx) which aims to apply recent state of the art technological advances in DNA vaccination and immune monitoring, both at the single cell and molecular level, to enable detailed probing of developing vaccine induced antibody responses.
ADITEC (Advanced Immunisation Technologies: http://www.aditecproject.eu) is funded under the 7th Framework by the EU. ADITEC is a collaborative research programme with 42 partners from 13 EU countries that aims to accelerate the development of novel and powerful immunisation technologies for the next generation of human vaccines. Professor Shattock leads the Prime-boost workpackage for the consortium.
BioVacSafe (Biomarkers for enhanced vaccines immunosafety - http://www.biovacsafe.eu) is a 5 years project funded by EU Innovative Medicine initiative (IMI). BioVacSafe aims to develop cutting edge tools to speed up and improve the testing and monitoring of vaccine safety, both before and after release to the market. It is a public private consortium of 19 partners involving three of Europe's leading vaccine producing companies, experts from major academic institutions, small and medium-sized enterprises (SMEs) and non-governmental organization (NGO): http://www.biovacsafe.eu/#sthash.UN2RSrBe.dpuf. Professor Shattock leads the work package on preclinical models.
The EAVI2020 consortium, funded under H2020 by the EU, is led by Prof Shattock at Imperial College London, and brings together leading HIV researchers from 23 public organisations and biotech companies from across Europe, Australia, Canada and the USA, pooling their knowledge and expertise to develop novel candidate vaccines that can be taken through to human trials within five years. http://www.eavi2020.eu. In addition to coordinating the programme, Prof Shattock’s group is responsible for performing a range of Experimental Medicine clinical trials of promising new HIV candidates.
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Publications
Journals
Dastgerdi NK, Gumus N, Bayraktutan H, et al., 2024, Charge neutralized poly(β-amino ester) polyplex nanoparticles for delivery of self-amplifying RNA., Nanoscale Adv, Vol:6, Pages:1409-1422
Olsen AW, Rosenkrands I, Jacobsen CS, et al., 2024, Immune signature of Chlamydia vaccine CTH522/CAF®01 translates from mouse-to-human and induces durable protection in mice., Nat Commun, Vol:15
Shattock RJ, Andrianaivoarimanana V, Mckay PF, et al., 2023, A self-amplifying RNA vaccine provides protection in a murine model of bubonic plague, Frontiers in Microbiology, Vol:14
Zhou J, Sukhova K, Peacock TP, et al., 2023, Omicron breakthrough infections in vaccinated or previously infected hamsters, Proceedings of the National Academy of Sciences of Usa, Vol:120, ISSN:0027-8424
Hayes G, Dias-Barbieri B, Yilmaz G, et al., 2023, Poly(2-oxazoline)/saRNA Polyplexes for Targeted and Nonviral Gene Delivery, Biomacromolecules, ISSN:1525-7797