Imperial College London
Alternate

ProfessorRobinShattock

Faculty of Medicine, Department of Infectious Disease

Chair in Mucosal Infection and Immunity
 
 
 
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Contact

 

+44 (0)20 7594 5206r.shattock

 
 
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Location

 

453Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Makinde:2018:10.1111/aji.12801,
author = {Makinde, J and Jones, C and Bartolf, A and Sibeko, S and Baden, S and Cosgrove, C and Shattock, RJ},
doi = {10.1111/aji.12801},
journal = {AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY},
title = {Localized cyclical variations in immunoproteins in the female genital tract and the implications on the design and assessment of mucosal infection and therapies},
url = {http://dx.doi.org/10.1111/aji.12801},
volume = {79},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - ProblemFluctuating hormones regulate reproductive processes in the female genital tract. Consequent changes in the local immunological environment are likely to affect cellular interaction with infectious agents and the assessment of therapies that target mucosal infections.Method of studyWe compared Softcup and WeckCel sampling protocols and assessed the changes in the concentrations of 39 soluble proteins with menstrual cycle progression in the mucosal and peripheral compartments.ResultsWe demonstrate that the mucosal immunological profile is distinct from serum with inflammatory and migratory signatures that are localized throughout the cycle. The analytes highlighted in the mucosal compartment were generally highest at the follicular phase with a tendency to fall as the cycle progressed through ovulation to the luteal phase.ConclusionOur results underscore the need to consider these localized cyclical differences in studies aimed at assessing the outcome of disease and the efficacy of mucosal vaccines and other therapies.
AU  - Makinde,J
AU  - Jones,C
AU  - Bartolf,A
AU  - Sibeko,S
AU  - Baden,S
AU  - Cosgrove,C
AU  - Shattock,RJ
DO  - 10.1111/aji.12801
PY  - 2018///
SN  - 1046-7408
TI  - Localized cyclical variations in immunoproteins in the female genital tract and the implications on the design and assessment of mucosal infection and therapies
T2  - AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
UR  - http://dx.doi.org/10.1111/aji.12801
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000423176200008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/60989
VL  - 79
ER  -
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