Imperial College London


Faculty of MedicineDepartment of Medicine

Research Manager



+44 (0)20 7594 7096r.tyacke




E514Burlington DanesHammersmith Campus





I am the Research Manager at the Centre for Neuropsychopharmacology and am involved in the management and implementation of experimental medicine and translation neuroscience research projects.  My main area of interest is the development and evaluation of novel PET ligands for neuroscience, as well as better understanding the cellular underpinning of the PET signal.  However, I also have interests in other neuroimaging techniques such as functional and pharmacological MR.



Mirzaei N, Tang S, Ashworth S, et al., In vivo Imaging of microglial activation by positron emission tomography with [11C]PBR28 in the 5XFAD model of Alzheimer’s disease, Glia, ISSN:0894-1491

Mirzaei N, Sac PT, Ashworth S, et al., 2016, In Vivo Imaging of Microglial Activation by Positron Emission Tomography with [C-11] PBR28 in the 5XFAD Model of Alzheimer's Disease, Glia, Vol:64, ISSN:0894-1491, Pages:993-1006

Carhart-Harris RL, Murphy K, Leech R, et al., 2015, The Effects of Acutely Administered 3,4-Methylenedioxymethamphetamine on Spontaneous Brain Function in Healthy Volunteers Measured with Arterial Spin Labeling and Blood Oxygen Level-Dependent Resting State Functional Connectivity, Biological Psychiatry, Vol:78, ISSN:0006-3223, Pages:554-562

Tyacke RJ, Nutt DJ, 2015, Optimising PET approaches to measuring 5-HT release in human brain, Synapse, Vol:69, ISSN:0887-4476, Pages:505-511

Quelch D, De Santis V, Strege A, et al., 2015, Influence of Agonist Induced Internalization on [H-3]Ro15-4513 Binding-An Application to Imaging Fluctuations in Endogenous GABA With Positron Emission Tomography, Synapse, Vol:69, ISSN:0887-4476, Pages:60-65

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