Imperial College London


Faculty of MedicineDepartment of Medicine

Research Manager



+44 (0)20 7594 7096r.tyacke




E514Burlington DanesHammersmith Campus





I am the Research Manager at the Centre for Neuropsychopharmacology and am involved in the management and implementation of experimental medicine and translation neuroscience research projects.  My main area of interest is the development and evaluation of novel PET ligands for neuroscience, as well as better understanding the cellular underpinning of the PET signal.  However, I also have interests in other neuroimaging techniques such as functional and pharmacological MR.



Mirzaei N, Tang S, Ashworth S, et al., In vivo Imaging of microglial activation by positron emission tomography with [11C]PBR28 in the 5XFAD model of Alzheimer’s disease, Glia, ISSN:0894-1491

Tyacke RJ, Myers JFM, Venkataraman A, et al., 2018, Evaluation of 11C-BU99008, a positron emission tomography ligand for the Imidazoline2 binding site in human brain., J Nucl Med

Mirzaei N, Sac PT, Ashworth S, et al., 2016, In Vivo Imaging of Microglial Activation by Positron Emission Tomography with [C-11] PBR28 in the 5XFAD Model of Alzheimer's Disease, Glia, Vol:64, ISSN:0894-1491, Pages:993-1006

Ghazaleh HA, Tyacke RJ, Hudson AL, 2015, Borne Identity: Leading Endogenous Suspects at Imidazoline Binding Sites, Journal of Neurology and Neuroscience, Vol:06


Tang SP, Mirzaei N, Coello C, et al., 2016, EVALUATION OF [11C]PBR28 PET IMAGING TO DETECT CHANGES IN MICROGLIAL ACTIVATION IN MOUSE MODELS OF ALZHEIMER'S DISEASE, 27th International Symposium on Cerebral Blood Flow, Metabolism and Function / 12th International Conference on Quantification of Brain Function with PET, SAGE PUBLICATIONS INC, Pages:654-655, ISSN:0271-678X

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