Imperial College London

Prof. Ramon Vilar

Faculty of Natural SciencesDepartment of Chemistry

Professor of Medicinal Inorganic Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 1967r.vilar Website

 
 
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Location

 

301HMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Publication Type
Year
to

167 results found

Mendoza C, Jansat S, Vilar R, Pericas MAet al., 2015, Clickable complexing agents: functional crown ethers for immobilisation onto polymers and magnetic nanoparticles, RSC ADVANCES, Vol: 5, Pages: 87352-87363, ISSN: 2046-2069

Journal article

Moffat CD, Weiss DJ, Shivalingam A, White AJP, Salauen P, Vilar Ret al., 2014, Molecular Recognition and Scavenging of Arsenate from Aqueous Solution Using Dimetallic Receptors, Chemistry-A European Journal, Vol: 20, Pages: 17168-17177, ISSN: 1521-3765

A series of copper(II), nickel(II) and zinc(II) dimetallic complexes were prepared and their affinities towards arsenate investigated. Indicator displacement assays (IDAs) were carried out to establish the complexes with best affinities towards arsenate. A di-zinc complex (3) was selected and its arsenate-binding abilities investigated by isothermal titration calorimetry (ITC). The X-ray crystal structure of this metallo-receptor bound to arsenate is also reported, which allowed us to establish the binding mode between 3 and this oxyanion. Immobilising 3 onto HypoGel resin yielded a novel adsorbent (Zn–HypoGel) with high affinity for arsenate. Adsorption of arsenate from competitive solutions and natural groundwater was greater than that of the commercially used iron oxide Bayoxide E33. Zn–HypoGel could be efficiently and simply regenerated by washing with sodium acetate solution.

Journal article

Stafford VS, Suntharalingam K, Shivalingam A, White AJP, Mann DJ, Vilar Ret al., 2014, Syntheses of polypyridyl metal complexes and studies of their interaction with quadruplex DNA, Dalton Transactions, Vol: 44, Pages: 3686-3700, ISSN: 1477-9226

A series of mono- and bi-metallic metal complexes (with CuII, PtII and ZnII) with substituted polypyridylligands have been prepared and their binding affinities towards quadruplex (c-Myc and human telomeric)and duplex DNA (ds26 and calf thymus) determined using fluorescent indicator displacement (FID) assaysand UV/vis spectroscopic titrations. These studies have shown that the number of aromatic rings andnumber/position of cyclic amine substituents on the ligands, play an important role in defining the DNAbinding abilities of the resulting metal complexes. We also show that bi-metallic complexes preparedusing a novel terpyridine-cyclen ligand have higher affinity towards G-quadruplex DNA as compared totheir mono-metallic counterparts. Cytotoxicity assays were carried out for all the new complexes againstan osteosarcoma cancer cell line (U2OS) as well as a normal fibroblast cell line (GM05757). Several ofthese compounds displayed cytotoxicity similar to that of cisplatin.

Journal article

Cilibrizzi A, Collins J, Woscholski R, Leatherbarrow R, Vilar Ret al., 2014, New vanadium complexes as optical probes to detect Cys sulfenic modifications in PTEN, 12th European Biological Inorganic Chemistry Conference (EuroBIC), Publisher: Springer Verlag (Germany), Pages: S873-S873, ISSN: 1432-1327

Conference paper

Stafford V, Shivalingam A, Suntharalingam K, Mann D, Vilar Ret al., 2014, Interaction of metal complexes with G-quadruplex DNA and their effects on gene expression, 12th European Biological Inorganic Chemistry Conference (EuroBIC), Publisher: SPRINGER, Pages: S740-S740, ISSN: 0949-8257

Conference paper

Zhou W, Vilar R, Ying L, Harding SEet al., 2014, Transcriptional regulatory roles of G-quadruplex DNA in promoters of genes involved in beta-adrenergic signaling pathway, CARDIOVASCULAR RESEARCH, Vol: 103, ISSN: 0008-6363

Journal article

Sala R, Quang-De N, Patel CBK, Mann D, Steinke JHG, Vilar R, Aboagye EOet al., 2014, Phosphorylation Status of Thymidine Kinase 1 Following Antiproliferative Drug Treatment Mediates 3 '-Deoxy-3 '-[F-18]-Fluorothymidine Cellular Retention, PLOS ONE, Vol: 9, ISSN: 1932-6203

Journal article

Ghosh S, Mendoza O, Cubo L, Rosu F, Gabelica V, White AJP, Vilar Ret al., 2014, Assembly of Palladium(II) and Platinum(II) Metallo-Rectangles with a Guanosine-Substituted Terpyridine and Study of Their Interactions with Quadruplex DNA, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 20, Pages: 4772-4779, ISSN: 0947-6539

Journal article

D'Arcy M, Bullough F, Moffat C, Borgomeo E, Teh M, Vilar R, Weiss DJet al., 2014, Adsorption of Oxy-Anions in the Teaching Laboratory: An Experiment To Study a Fundamental Environmental Engineering Problem, JOURNAL OF CHEMICAL EDUCATION, Vol: 91, Pages: 505-510, ISSN: 0021-9584

Journal article

Leczkowska A, Vilar R, 2014, Targeting quadruplex nucleic acids with metal complexes, 16th International Conference on Biological Inorganic Chemistry (ICBIC), Publisher: SPRINGER, Pages: S378-S378, ISSN: 0949-8257

Conference paper

Pujol A, Vilar R, 2014, Multimetallic and Bifunctional MRI-probes for imaging apoptotic cells., 16th International Conference on Biological Inorganic Chemistry (ICBIC), Publisher: SPRINGER, Pages: S620-S620, ISSN: 0949-8257

Conference paper

Ali SMH, Yan Y-K, Lee PPF, Khong KZX, Sk MA, Lim KH, Klejevskaja B, Vilar Ret al., 2014, Copper(II) complexes of substituted salicylaldehyde dibenzyl semicarbazones: synthesis, cytotoxicity and interaction with quadruplex DNA, DALTON TRANSACTIONS, Vol: 43, Pages: 1449-1459, ISSN: 1477-9226

Journal article

Karim NHA, Mendoza O, Shivalingam A, Thompson AJ, Ghosh S, Kuimova MK, Vilar Ret al., 2014, Salphen metal complexes as tunable G-quadruplex binders and optical probes, RSC ADVANCES, Vol: 4, Pages: 3355-3363, ISSN: 2046-2069

Journal article

Łȩczkowska A, Vilar R, 2013, Interaction of metal complexes with nucleic acids, Annual Reports on the Progress of Chemistry - Section A, Vol: 109, Pages: 299-316, ISSN: 0260-1818

This chapter reviews the literature reported during 2012 in the field of interaction of metal complexes with nucleic acids, also covering complex formation between transition metal ions and coordinating moieties within nucleic acids. As for the previous year, we have divided the chapter into three sections. The first focuses on the interaction of metal centres with DNA and is organised according to mode of interaction. The second section presents studies of metal complexes and metal ions that interact with RNA. In the last section we discuss examples where transition metals occupy coordination sites covalently incorporated within nucleic acids strands. © 2013 The Royal Society of Chemistry.

Journal article

von Grebe P, Suntharalingam K, Vilar R, Sanz Miguel PJ, Herres-Pawlis S, Lippert Bet al., 2013, A Conformationally Flexible Dinuclear Pt-II Complex with Differential Behavior of its Two States toward Quadruplex DNA, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 19, Pages: 11429-11438, ISSN: 0947-6539

Journal article

Whyte GF, Vilar R, Woscholski R, 2013, Molecular recognition with boronic acids-applications in chemical biology., J Chem Biol, Vol: 6, Pages: 161-174, ISSN: 1864-6158

Small molecules have long been used for the selective recognition of a wide range of analytes. The ability of these chemical receptors to recognise and bind to specific targets mimics certain biological processes (such as protein-substrate interactions) and has therefore attracted recent interest. Due to the abundance of biological molecules possessing polyhydroxy motifs, boronic acids-which form five-membered boronate esters with diols-have become increasingly popular in the synthesis of small chemical receptors. Their targets include biological materials and natural products including phosphatidylinositol bisphosphate, saccharides and polysaccharides, nucleic acids, metal ions and the neurotransmitter dopamine. This review will focus on the many ways in which small chemical receptors based on boronic acids have been used as biochemical tools for various purposes, including sensing and detection of analytes, interference in signalling pathways, enzyme inhibition and cell delivery systems. The most recent developments in each area will be highlighted.

Journal article

Cowell S, Nguyen Q-D, Twyman F, Lavdas I, Carroll L, Vilar R, Aboagye Eet al., 2013, Towards multimodal molecular probes responsive to matrix metalloproteinases, JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, Vol: 56, Pages: S235-S235, ISSN: 0362-4803

Journal article

Sala R, Quang-De N, Patel C, Mann D, Steinke JHG, Vilar R, Aboagye EOet al., 2013, Regulation of 18F-fluorothymidine uptake by thymidine kinase 1 protein phosphorylation., 104th Annual Meeting of the American-Association-for-Cancer-Research (AACR), Publisher: AMER ASSOC CANCER RESEARCH, ISSN: 0008-5472

Conference paper

Zhou W, Suntharalingam K, Brand NJ, Barton PJR, Vilar R, Ying Let al., 2013, Possible Regulatory Roles of Promoter G-Quadruplexes in Cardiac Function-Related Genes - Human TnIc as a Model, PLOS One, Vol: 8, ISSN: 1932-6203

G-quadruplexes (G4s) are four-stranded DNA secondary structures, which are involved in a diverse range of biological processes. Although the anti-cancer potential of G4s in oncogene promoters has been thoroughly investigated, the functions of promoter G4s in non-cancer-related genes are not well understood. We have explored the possible regulatory roles of promoter G4s in cardiac function-related genes using both computational and a wide range of experimental approaches. According to our bioinformatics results, it was found that potential G4-forming sequences are particularly enriched in the transcription regulatory regions (TRRs) of cardiac function-related genes. Subsequently, the promoter of human cardiac troponin I (TnIc) was chosen as a model, and G4s found in this region were subjected to biophysical characterisations. The chromosome 19 specific minisatellite G4 sequence (MNSG4) and near transcription start site (TSS) G4 sequence (−80 G4) adopt anti-parallel and parallel structures respectively in 100 mM KCl, with stabilities comparable to those of oncogene G4s. It was also found that TnIc G4s act cooperatively as enhancers in gene expression regulation in HEK293 cells, when stabilised by a synthetic G4-binding ligand. This study provides the first evidence of the biological significance of promoter G4s in cardiac function-related genes. The feasibility of using a single ligand to target multiple G4s in a particular gene has also been discussed.

Journal article

Suntharalingam K, Mendoza O, Duarte AA, Mann DJ, Vilar Ret al., 2013, A platinum complex that binds non-covalently to DNA and induces cell death via a different mechanism than cisplatin, METALLOMICS, Vol: 5, Pages: 514-523, ISSN: 1756-5901

Journal article

Ghosh S, Silber GT, White AJP, Robertson N, Vilar Ret al., 2013, Synthesis of a self-assembled copper(II) metallo-rectangle with a guanosine-substituted terpyridine, DALTON TRANSACTIONS, Vol: 42, Pages: 13813-13816, ISSN: 1477-9226

Journal article

Jimeno C, Christmann U, Escudero-Adan EC, Vilar R, Pericas MAet al., 2012, Studies on the Amination of Aryl Chlorides with a Monoligated Palladium Catalyst: Kinetic Evidence for a Cooperative Mechanism, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 18, Pages: 16510-16516, ISSN: 0947-6539

Journal article

Suntharalingam K, Leczkowska A, Furrer MA, Wu Y, Kuimova MK, Therrien B, White AJP, Vilar Ret al., 2012, A Cyclometallated Platinum Complex as a Selective Optical Switch for Quadruplex DNA, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 18, Pages: 16277-16282, ISSN: 0947-6539

Journal article

Łeczkowska A, Vilar R, 2012, Interaction of metal complexes with nucleic acids, Annual Reports on the Progress of Chemistry - Section A, Vol: 108, Pages: 330-349, ISSN: 0260-1818

This chapter reviews the literature reported during 2011 in the field of interaction of metal complexes with nucleic acids, also covering complex formation between transition metal ions and coordinating moieties within nucleic acids. As for the previous year, we have divided the chapter into three sections. The first focuses on the interaction of metal centres with DNA and is organised according to mode of interaction. The second section presents studies of metal complexes and metal ions that interact with RNA. In the last section we discuss examples where transition metals occupy coordination sites covalently incorporated within nucleic acids strands. © 2012 The Royal Society of Chemistry.

Journal article

Suntharalingam K, Hunt DJ, Duarte AA, White AJP, Mann DJ, Vilar Ret al., 2012, A Tri-copper(II) Complex Displaying DNA-Cleaving Properties and Antiproliferative Activity against Cancer Cells, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 18, Pages: 15133-15141, ISSN: 0947-6539

Journal article

Tate CW, Gee AD, Vilar R, White AJP, Long NJet al., 2012, Reversible carbon monoxide binding at copper(I) P-S-X (X=N, O) coordination polymers, JOURNAL OF ORGANOMETALLIC CHEMISTRY, Vol: 715, Pages: 39-42, ISSN: 0022-328X

Journal article

Herranz F, Schmidt-Weber CB, Shamji MH, Narkus A, Ruiz-Cabello J, Vilar Ret al., 2012, Superparamagnetic iron oxide nanoparticles conjugated to a grass pollen allergen and an optical probe, CONTRAST MEDIA & MOLECULAR IMAGING, Vol: 7, Pages: 435-439, ISSN: 1555-4309

Journal article

Campbell NH, Abd Karim NH, Parkinson GN, Gunaratnam M, Petrucci V, Todd AK, Vilar R, Neidle Set al., 2012, Molecular Basis of Structure-Activity Relationships between Salphen Metal Complexes and Human Telomeric DNA Quadruplexes, JOURNAL OF MEDICINAL CHEMISTRY, Vol: 55, Pages: 209-222, ISSN: 0022-2623

Journal article

Marti-Centelles V, Isabel Burguete M, Galindo F, Angeles Izquierdo M, Kumar DK, White AJP, Luis SV, Vilar Ret al., 2012, Fluorescent Acridine-Based Receptors for H2PO4-, JOURNAL OF ORGANIC CHEMISTRY, Vol: 77, Pages: 490-500, ISSN: 0022-3263

Journal article

Tate CW, deMello A, Gee AD, Kealey S, Vilar R, White AJP, Long NJet al., 2012, Hemilabile and reversible carbon monoxide binding properties of iron(II), cobalt(II) and nickel(II) complexes containing a new tridentate P-S-N ligand, DALTON TRANSACTIONS, Vol: 41, Pages: 83-89, ISSN: 1477-9226

Journal article

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