Imperial College London

Prof. Ramon Vilar

Faculty of Natural SciencesDepartment of Chemistry

Professor of Medicinal Inorganic Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 1967r.vilar Website

 
 
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Location

 

301HMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Publication Type
Year
to

166 results found

Child ES, Georgiades SN, Rose KN, Stafford VS, Patel CBK, Steinke JHG, Mann DJ, Vilar Ret al., 2011, Inhibition of mitogen-activated protein kinase (MAPK) and cyclin-dependent kinase 2 (Cdk2) by platinum(II) phenanthroline complexes., J Chem Biol, Vol: 4, Pages: 159-165

UNLABELLED: Inhibition of protein kinases in the fight against disease remains a constant challenge for medicinal chemists, who have screened multitudes of predominantly planar organic scaffolds, natural and synthetic, to identify potent-albeit not always selective-kinase inhibitors. Herein, in an effort to investigate the potential biological utility of metal-based compounds as inhibitors against the cancer-relevant targets mitogen-activated protein kinase and cyclin-dependent kinase 2, we explore various parameters in planar platinum(II) complexes with substituted phenanthroline ligands and aliphatic diamine chelate co-ligands, to identify combinations that yield promising inhibitory activity. The individual ligands' steric requirements as well as their pattern of hydrogen bond donors/acceptors appear to alter inhibitory potency when modulated. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s12154-011-0059-5) contains supplementary material, which is available to authorized users.

Journal article

Mak LH, Georgiades SN, Rosivatz E, Whyte GF, Mirabelli M, Vilar R, Woscholski Ret al., 2011, A Small Molecule Mimicking a Phosphatidylinositol (4,5)-Bisphosphate Binding Pleckstrin Homology Domain, ACS Chemical Biology, ISSN: 1554-8929

Journal article

Suntharalingam K, Vilar R, 2011, Interaction of metal complexes with nucleic acids, Annual Reports on the Progress of Chemistry - Section A, Vol: 107, Pages: 339-358, ISSN: 0260-1818

This chapter, divided into three sections, reviews the literature reported during 2010 in the field of interaction of metal complexes with nucleic acids and complex formation between metals and coordinating moieties within nucleic acids. The first two sections focus on the interaction of metal complexes and ions with DNA and RNA, respectively, and are organised by mode of interaction. In the last section examples where transition metals occupy coordination sites covalently incorporated within nucleic acids strands' are discussed. © 2011 The Royal Society of Chemistry.

Journal article

Campbelll NH, Karim NHA, Parkinson GN, Vilar R, Neidie Set al., 2011, The first crystal structure of a telomeric quadruplex DNA with a metal containing ligand, CANCER RESEARCH, Vol: 71, ISSN: 0008-5472

Journal article

Georgiades S, Mak L, Angurell I, Rosivatz E, Firouz Mohd Mustapa M, Polychroni C, Woscholski R, Vilar Ret al., 2011, Identification of a potent activator of Akt phosphorylation from a novel series of phenolic, picolinic, pyridino, and hydroxamic zinc(II) complexes, Journal of Biological Inorganic Chemistry, Vol: 16, Pages: 195-208, ISSN: 0949-8257

Journal article

Li X, Nazeeruddin MK, Thelakkat M, Barnes PRF, Vilar R, Durrant JRet al., 2011, Spectroelectrochemical studies of hole percolation on functionalised nanocrystalline TiO2 films: a comparison of two different ruthenium complexes, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, Vol: 13, Pages: 1575-1584, ISSN: 1463-9076

Journal article

Buscemi G, Miller PW, Kealey S, Gee AD, Long NJ, Passchier J, Vilar Ret al., 2011, Rapid carbonylative coupling reactions using palladium(I) dimers: applications to (CO)-C-11-radiolabelling for the synthesis of PET tracers, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol: 9, Pages: 3499-3503, ISSN: 1477-0520

Journal article

Marti-Centelles V, Kumar DK, White AJP, Luis SV, Vilar Ret al., 2011, Zinc(ii) coordination polymers with pseudopeptidic ligands, CrystEngComm, Vol: 13, Pages: 6997-7008

Two new phenyl-bridged pseudopeptidic ligands have been prepared and structurally characterised. The nature of the ligands' substituents play an important role in the nature of the solid state structure yielding either hydrogen bonded linked sheets of molecules or infinite hydrogen bonded networks. Both these ligands were reacted with a range of zinc(ii) salts with the aim of synthesising coordination polymers and networks and exploring the role that anions could play in determining the final structure. The crystal structures of four of these systems (with ZnSO4 and ZnBr2) were determined; in one case, a 3D coordination network was obtained where zinc-ligand coordination bonds generated the 3D arrangements. Three other 3D networks were obtained by anion-mediated hydrogen bonding of coordination 1D chains or 2D sheets. These four very different structures highlight the important role played by the ligands' substituents and the counteranions present in the system.

Journal article

D'Arcy M, Weiss DJ, Bluck M, Vilar Ret al., 2011, Adsorption kinetics, capacity and mechanism of arsenate and phosphate on a bifunctional TiO2-Fe2O3 bi-composite, Journal of Colloid and Interface Science, Vol: 364, Pages: 205-212

Journal article

Surman AJ, Bonnet CS, Lowe MP, Kenny GD, Bell JD, Toth E, Vilar Ret al., 2011, A Pyrophosphate-Responsive Gadolinium(III) MRI Contrast Agent, Chemistry - A European Journal, Vol: 17, Pages: 223-230, ISSN: 0947-6539

Journal article

Miller PW, Audrain H, Bender D, deMello AJ, Gee AD, Long NJ, Vilar Ret al., 2011, Rapid Carbon-11 Radiolabelling for PET Using Microfluidics, Chemistry - A European Journal, Vol: 17, Pages: 460-463

Journal article

Surman AJ, Kenny GD, Kumar DK, Bell JD, Casey DR, Vilar Ret al., 2011, Targeting of anionic membrane species by lanthanide(iii) complexes: towards improved MRI contrast agents for apoptosis, Chemical Communications, ISSN: 1359-7345

Journal article

Mak L, Vilar R, Woscholski R, 2010, Characterisation of the PTEN inhibitor VO-OHpic, Journal of Chemical Biology, Vol: 3, Pages: 157-163, ISSN: 1864-6158

Journal article

Suntharalingam K, White AJP, Vilar R, 2010, Two Metals Are Better than One: Investigations on the Interactions between Dinuclear Metal Complexes and Quadruplex DNA, INORGANIC CHEMISTRY, Vol: 49, Pages: 8371-8380, ISSN: 0020-1669

Journal article

Vilar R, Suntharalingam K, 2010, Two metals are better than one: Interactions between dinuclear metal complexes and quadruplex DNA, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol: 240, ISSN: 0065-7727

Journal article

Georgiades SN, Vilar R, 2010, Interaction of metal complexes with nucleic acids, Annual Reports on the Progress of Chemistry - Section A, Vol: 106, Pages: 481-503, ISSN: 0260-1818

This chapter reviews the literature reported during 2009 in the field of interaction of metal complexes with nucleic acids, also covering complex formation between transition metal ions and coordinating moieties within nucleic acids. The chapter has been divided into three sections. The first focuses on the interaction of metal complexes with DNA and is organised according to mode of interaction. The second section discusses examples of metal complexes and metal ions that interact with RNA. The last section presents examples where transition metal cations occupy coordination sites covalently incorporated within DNA strands to yield materials with distinct properties. © 2010 The Royal Society of Chemistry.

Journal article

Martinelli J, Balali-Mood B, Panizzo R, Lythgoe MF, White AJP, Ferretti P, Steinke JHG, Vilar Ret al., 2010, Coordination chemistry of amide-functionalised tetraazamacrocycles: structural, relaxometric and cytotoxicity studies, DALTON TRANSACTIONS, Vol: 39, Pages: 10056-10067, ISSN: 1477-9226

Journal article

Georgiades SN, Abd Karim NH, Suntharalingam K, Vilar Ret al., 2010, Interaction of Metal Complexes with G-Quadruplex DNA, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 49, Pages: 4020-4034, ISSN: 1433-7851

Journal article

Suntharalingam K, Gupta D, Miguel PJS, Lippert B, Vilar Ret al., 2010, Synthesis, Structural Characterisation and Quadruplex DNA Binding Studies of a New Gold(III) Pyrazolylpyridine Complex, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 16, Pages: 3613-3616, ISSN: 0947-6539

Journal article

He X, Herranz F, Cheng EC-C, Vilar R, Yam VW-Wet al., 2010, Design, Synthesis, Photophysics, and Anion-Binding Studies of Bis(dicyclohexylphosphino)methane-Containing Dinuclear Gold(I) Thiolate Complexes with Urea Receptors, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 16, Pages: 9123-9131, ISSN: 0947-6539

Journal article

Owen GR, White AJP, Vilar R, 2009, Palladium Iminoacyl Imine Complexes: Strategies toward Imine Insertion, ORGANOMETALLICS, Vol: 28, Pages: 5783-5793, ISSN: 0276-7333

Journal article

Suntharalingam K, White AJP, Vilar R, 2009, Synthesis, Structural Characterization, and Quadruplex DNA Binding Studies of Platinum(II)-Terpyridine Complexes, INORGANIC CHEMISTRY, Vol: 48, Pages: 9427-9435, ISSN: 0020-1669

Journal article

Vilar R, 2009, Bioinorganic chemistry, Annual Reports on the Progress of Chemistry - Section A, Vol: 105, Pages: 477-504, ISSN: 0260-1818

This chapter reviews the literature reported during 2008 in the field of bioinorganic chemistry. The chapter focuses on metalloproteins that contain d-block metals on their active site and highlights some relevant bio-mimetic models. The interactions of d-block metals with peptides and biological chelators are also presented. © The Royal Society of Chemistry 2009.

Journal article

Barry NPE, Abd Karim NH, Vilar R, Therrien Bet al., 2009, Interactions of ruthenium coordination cubes with DNA, DALTON TRANSACTIONS, Pages: 10717-10719, ISSN: 1477-9226

Journal article

Miller P, Long N, Vilar R, de Mello A, Gee A, Bender D, Audrain H, Golonka L, Malecha Ket al., 2009, NOVEL MICROREACTOR TECHNOLOGIES FOR 11C RADIOLABELLING, Publisher: JOHN WILEY & SONS LTD, Pages: S13-S13, ISSN: 0362-4803

Conference paper

Mendoza C, Benet-Buchholz J, Pericas MA, Vilar Ret al., 2009, Di-platinum complexes containing thiolato-urea ligands: structural and anion binding studies, DALTON TRANSACTIONS, Pages: 2974-2985, ISSN: 1477-9226

Journal article

Reed JE, White AJP, Neidle S, Vilar Ret al., 2009, Effect of metal coordination on the interaction of substituted phenanthroline and pyridine ligands with quadruplex DNA, DALTON TRANSACTIONS, Pages: 2558-2568, ISSN: 1477-9226

Journal article

Miller PW, Jennings LE, deMello AJ, Gee AD, Long NJ, Vilar Ret al., 2009, A microfluidic approach to the rapid screening of palladium catalysed aminocarbonylation reactions, Advanced Synthesis and Catalysis, Vol: 351, Pages: 3260-3268

Journal article

Arola-Arnal A, Benet-Buchholz J, Neidle S, Vilar Ret al., 2008, Effects of Metal Coordination Geometry on Stabilization of Human Telomeric Quadruplex DNA by Square-Planar and Square-Pyramidal Metal Complexes, INORGANIC CHEMISTRY, Vol: 47, Pages: 11910-11919, ISSN: 0020-1669

Journal article

Herranz F, Puerto Morales M, Roca AG, Vilar R, Ruiz-Cabello Jet al., 2008, A new method for the aqueous functionalization of superparamagnetic Fe2O3 nanoparticles, CONTRAST MEDIA & MOLECULAR IMAGING, Vol: 3, Pages: 215-222, ISSN: 1555-4309

Journal article

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