166 results found
Child ES, Georgiades SN, Rose KN, et al., 2011, Inhibition of mitogen-activated protein kinase (MAPK) and cyclin-dependent kinase 2 (Cdk2) by platinum(II) phenanthroline complexes., J Chem Biol, Vol: 4, Pages: 159-165
UNLABELLED: Inhibition of protein kinases in the fight against disease remains a constant challenge for medicinal chemists, who have screened multitudes of predominantly planar organic scaffolds, natural and synthetic, to identify potent-albeit not always selective-kinase inhibitors. Herein, in an effort to investigate the potential biological utility of metal-based compounds as inhibitors against the cancer-relevant targets mitogen-activated protein kinase and cyclin-dependent kinase 2, we explore various parameters in planar platinum(II) complexes with substituted phenanthroline ligands and aliphatic diamine chelate co-ligands, to identify combinations that yield promising inhibitory activity. The individual ligands' steric requirements as well as their pattern of hydrogen bond donors/acceptors appear to alter inhibitory potency when modulated. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s12154-011-0059-5) contains supplementary material, which is available to authorized users.
Mak LH, Georgiades SN, Rosivatz E, et al., 2011, A Small Molecule Mimicking a Phosphatidylinositol (4,5)-Bisphosphate Binding Pleckstrin Homology Domain, ACS Chemical Biology, ISSN: 1554-8929
Suntharalingam K, Vilar R, 2011, Interaction of metal complexes with nucleic acids, Annual Reports on the Progress of Chemistry - Section A, Vol: 107, Pages: 339-358, ISSN: 0260-1818
This chapter, divided into three sections, reviews the literature reported during 2010 in the field of interaction of metal complexes with nucleic acids and complex formation between metals and coordinating moieties within nucleic acids. The first two sections focus on the interaction of metal complexes and ions with DNA and RNA, respectively, and are organised by mode of interaction. In the last section examples where transition metals occupy coordination sites covalently incorporated within nucleic acids strands' are discussed. © 2011 The Royal Society of Chemistry.
Campbelll NH, Karim NHA, Parkinson GN, et al., 2011, The first crystal structure of a telomeric quadruplex DNA with a metal containing ligand, CANCER RESEARCH, Vol: 71, ISSN: 0008-5472
Georgiades S, Mak L, Angurell I, et al., 2011, Identification of a potent activator of Akt phosphorylation from a novel series of phenolic, picolinic, pyridino, and hydroxamic zinc(II) complexes, Journal of Biological Inorganic Chemistry, Vol: 16, Pages: 195-208, ISSN: 0949-8257
Li X, Nazeeruddin MK, Thelakkat M, et al., 2011, Spectroelectrochemical studies of hole percolation on functionalised nanocrystalline TiO2 films: a comparison of two different ruthenium complexes, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, Vol: 13, Pages: 1575-1584, ISSN: 1463-9076
Buscemi G, Miller PW, Kealey S, et al., 2011, Rapid carbonylative coupling reactions using palladium(I) dimers: applications to (CO)-C-11-radiolabelling for the synthesis of PET tracers, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol: 9, Pages: 3499-3503, ISSN: 1477-0520
Marti-Centelles V, Kumar DK, White AJP, et al., 2011, Zinc(ii) coordination polymers with pseudopeptidic ligands, CrystEngComm, Vol: 13, Pages: 6997-7008
Two new phenyl-bridged pseudopeptidic ligands have been prepared and structurally characterised. The nature of the ligands' substituents play an important role in the nature of the solid state structure yielding either hydrogen bonded linked sheets of molecules or infinite hydrogen bonded networks. Both these ligands were reacted with a range of zinc(ii) salts with the aim of synthesising coordination polymers and networks and exploring the role that anions could play in determining the final structure. The crystal structures of four of these systems (with ZnSO4 and ZnBr2) were determined; in one case, a 3D coordination network was obtained where zinc-ligand coordination bonds generated the 3D arrangements. Three other 3D networks were obtained by anion-mediated hydrogen bonding of coordination 1D chains or 2D sheets. These four very different structures highlight the important role played by the ligands' substituents and the counteranions present in the system.
D'Arcy M, Weiss DJ, Bluck M, et al., 2011, Adsorption kinetics, capacity and mechanism of arsenate and phosphate on a bifunctional TiO2-Fe2O3 bi-composite, Journal of Colloid and Interface Science, Vol: 364, Pages: 205-212
Surman AJ, Bonnet CS, Lowe MP, et al., 2011, A Pyrophosphate-Responsive Gadolinium(III) MRI Contrast Agent, Chemistry - A European Journal, Vol: 17, Pages: 223-230, ISSN: 0947-6539
Miller PW, Audrain H, Bender D, et al., 2011, Rapid Carbon-11 Radiolabelling for PET Using Microfluidics, Chemistry - A European Journal, Vol: 17, Pages: 460-463
Surman AJ, Kenny GD, Kumar DK, et al., 2011, Targeting of anionic membrane species by lanthanide(iii) complexes: towards improved MRI contrast agents for apoptosis, Chemical Communications, ISSN: 1359-7345
Mak L, Vilar R, Woscholski R, 2010, Characterisation of the PTEN inhibitor VO-OHpic, Journal of Chemical Biology, Vol: 3, Pages: 157-163, ISSN: 1864-6158
Suntharalingam K, White AJP, Vilar R, 2010, Two Metals Are Better than One: Investigations on the Interactions between Dinuclear Metal Complexes and Quadruplex DNA, INORGANIC CHEMISTRY, Vol: 49, Pages: 8371-8380, ISSN: 0020-1669
Vilar R, Suntharalingam K, 2010, Two metals are better than one: Interactions between dinuclear metal complexes and quadruplex DNA, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol: 240, ISSN: 0065-7727
Georgiades SN, Vilar R, 2010, Interaction of metal complexes with nucleic acids, Annual Reports on the Progress of Chemistry - Section A, Vol: 106, Pages: 481-503, ISSN: 0260-1818
This chapter reviews the literature reported during 2009 in the field of interaction of metal complexes with nucleic acids, also covering complex formation between transition metal ions and coordinating moieties within nucleic acids. The chapter has been divided into three sections. The first focuses on the interaction of metal complexes with DNA and is organised according to mode of interaction. The second section discusses examples of metal complexes and metal ions that interact with RNA. The last section presents examples where transition metal cations occupy coordination sites covalently incorporated within DNA strands to yield materials with distinct properties. © 2010 The Royal Society of Chemistry.
Martinelli J, Balali-Mood B, Panizzo R, et al., 2010, Coordination chemistry of amide-functionalised tetraazamacrocycles: structural, relaxometric and cytotoxicity studies, DALTON TRANSACTIONS, Vol: 39, Pages: 10056-10067, ISSN: 1477-9226
Georgiades SN, Abd Karim NH, Suntharalingam K, et al., 2010, Interaction of Metal Complexes with G-Quadruplex DNA, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 49, Pages: 4020-4034, ISSN: 1433-7851
Suntharalingam K, Gupta D, Miguel PJS, et al., 2010, Synthesis, Structural Characterisation and Quadruplex DNA Binding Studies of a New Gold(III) Pyrazolylpyridine Complex, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 16, Pages: 3613-3616, ISSN: 0947-6539
He X, Herranz F, Cheng EC-C, et al., 2010, Design, Synthesis, Photophysics, and Anion-Binding Studies of Bis(dicyclohexylphosphino)methane-Containing Dinuclear Gold(I) Thiolate Complexes with Urea Receptors, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 16, Pages: 9123-9131, ISSN: 0947-6539
Owen GR, White AJP, Vilar R, 2009, Palladium Iminoacyl Imine Complexes: Strategies toward Imine Insertion, ORGANOMETALLICS, Vol: 28, Pages: 5783-5793, ISSN: 0276-7333
Suntharalingam K, White AJP, Vilar R, 2009, Synthesis, Structural Characterization, and Quadruplex DNA Binding Studies of Platinum(II)-Terpyridine Complexes, INORGANIC CHEMISTRY, Vol: 48, Pages: 9427-9435, ISSN: 0020-1669
Vilar R, 2009, Bioinorganic chemistry, Annual Reports on the Progress of Chemistry - Section A, Vol: 105, Pages: 477-504, ISSN: 0260-1818
This chapter reviews the literature reported during 2008 in the field of bioinorganic chemistry. The chapter focuses on metalloproteins that contain d-block metals on their active site and highlights some relevant bio-mimetic models. The interactions of d-block metals with peptides and biological chelators are also presented. © The Royal Society of Chemistry 2009.
Barry NPE, Abd Karim NH, Vilar R, et al., 2009, Interactions of ruthenium coordination cubes with DNA, DALTON TRANSACTIONS, Pages: 10717-10719, ISSN: 1477-9226
Miller P, Long N, Vilar R, et al., 2009, NOVEL MICROREACTOR TECHNOLOGIES FOR 11C RADIOLABELLING, Publisher: JOHN WILEY & SONS LTD, Pages: S13-S13, ISSN: 0362-4803
Mendoza C, Benet-Buchholz J, Pericas MA, et al., 2009, Di-platinum complexes containing thiolato-urea ligands: structural and anion binding studies, DALTON TRANSACTIONS, Pages: 2974-2985, ISSN: 1477-9226
Reed JE, White AJP, Neidle S, et al., 2009, Effect of metal coordination on the interaction of substituted phenanthroline and pyridine ligands with quadruplex DNA, DALTON TRANSACTIONS, Pages: 2558-2568, ISSN: 1477-9226
Miller PW, Jennings LE, deMello AJ, et al., 2009, A microfluidic approach to the rapid screening of palladium catalysed aminocarbonylation reactions, Advanced Synthesis and Catalysis, Vol: 351, Pages: 3260-3268
Arola-Arnal A, Benet-Buchholz J, Neidle S, et al., 2008, Effects of Metal Coordination Geometry on Stabilization of Human Telomeric Quadruplex DNA by Square-Planar and Square-Pyramidal Metal Complexes, INORGANIC CHEMISTRY, Vol: 47, Pages: 11910-11919, ISSN: 0020-1669
Herranz F, Puerto Morales M, Roca AG, et al., 2008, A new method for the aqueous functionalization of superparamagnetic Fe2O3 nanoparticles, CONTRAST MEDIA & MOLECULAR IMAGING, Vol: 3, Pages: 215-222, ISSN: 1555-4309
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