Imperial College London

Prof. Ramon Vilar

Faculty of Natural SciencesDepartment of Chemistry

Professor of Medicinal Inorganic Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 1967r.vilar Website

 
 
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Location

 

301HMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Publication Type
Year
to

166 results found

Arola A, Vilar R, 2008, Stabilisation of G-Quadruplex DNA by Small Molecules, CURRENT TOPICS IN MEDICINAL CHEMISTRY, Vol: 8, Pages: 1405-1415, ISSN: 1568-0266

Journal article

Reed J, Gunaratnam M, Beltran M, Reszka AP, Vilar R, Neidle Set al., 2008, TRAP-LIG, a modified telomere repeat amplification protocol assay to quantitate telomerase inhibition by small molecules, ANALYTICAL BIOCHEMISTRY, Vol: 380, Pages: 99-105, ISSN: 0003-2697

Journal article

Long NJ, Miller PW, de Mello A, Vilar R, Gee ADet al., 2008, INOR 301-New strategies for 11-carbon labeling in PET: From fast synthesis to microfluidics, 236th National Meeting of the American-Chemical-Society, Publisher: AMER CHEMICAL SOC, ISSN: 0065-7727

Conference paper

Vilar R, 2008, Structure and Bonding: Preface, ISBN: 9783540790914

Book

Miller PW, Long NJ, Vilar R, Gee ADet al., 2008, Synthetic radiolabelling strategies for radiotracers in Positron Emission Tomography (PET) imaging, Angewandte Chemie Int. Ed., Vol: 47, Pages: 8998-9033

Journal article

Gimeno N, Li X, Durrant JR, Vilar Ret al., 2008, Cyanide sensing with organic dyes: Studies in solution and on nanostructured Al(2)O(3) surfaces, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 14, Pages: 3006-3012, ISSN: 0947-6539

Journal article

Vilar R, 2008, Anion templates in synthesis and dynamic combinatorial libraries, RECOGNITION OF ANIONS, Vol: 129, Pages: 175-206, ISSN: 0081-5993

Journal article

Vilar R, 2008, Anion recognition and templation in coordination chemistry, EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, Pages: 357-367, ISSN: 1434-1948

Journal article

Tovilla JA, Carlqvist P, Benet-Buchholz J, Maseras F, Vilar Ret al., 2007, Di-palladium complexes with urea-containing ligands as anion receptors, SUPRAMOLECULAR CHEMISTRY, Vol: 19, Pages: 599-611, ISSN: 1061-0278

Journal article

Vilar R, 2007, PET Imaging in Chemical Biology, Chemical Biology: Applications and Techniques, Pages: 217-229, ISBN: 9780470090640

Book chapter

Gimeno N, Formentin P, Steinke JHG, Vilar Ret al., 2007, Phenylphosphoric acid as a new additive to inhibit olefin isomerisation in ruthenium-catalysed metathesis reactions, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Pages: 918-924, ISSN: 1434-193X

Journal article

Shalom D, Wootton RCR, Winkle RF, Cottam BF, Vilar R, deMello AJ, Wilde CPet al., 2007, Synthesis of thiol functionalized gold nanoparticles using a continuous flow microfluidic reactor, MATERIALS LETTERS, Vol: 61, Pages: 1146-1150, ISSN: 0167-577X

Journal article

Diaz P, Tovilla JA, Ballester P, Benet-Buchholz J, Vilar Ret al., 2007, Synthesis, structural characterization and anion binding studies of palladium macrocycles with hydrogen-bonding ligands, DALTON TRANSACTIONS, Pages: 3516-3525, ISSN: 1477-9226

Journal article

Reed JE, Neidle S, Vilar R, 2007, Stabilisation of human telomeric quadruplex DNA and inhibition of telomerase by a platinum-phenanthroline complex, CHEMICAL COMMUNICATIONS, Pages: 4366-4368, ISSN: 1359-7345

Journal article

Miller PW, Long NJ, de Mello AJ, Vilar R, Audrain H, Bender D, Passchier J, Gee Aet al., 2007, Rapid multiphase carbonylation reactions using a micro-tube reactor: Applications in Positron Emission Tomography (PET) 11C-Radiolabelling, Angewandte Chemie International Edition, Vol: 46, Pages: 2875-2878

Journal article

Christmann U, Pantazis DA, Benet-Buchholz J, McGrady JE, Maseras F, Vilar Ret al., 2006, Synthesis and computational studies of palladium(I) dimers Pd2X2((PBu2Ph)-Bu-t)(2) (X = Br, I): Phenyl versus halide bridging modes, ORGANOMETALLICS, Vol: 25, Pages: 5990-5995, ISSN: 0276-7333

Journal article

Rosivatz E, Matthews JG, McDonald NQ, Mulet X, Ho KK, Lossi N, Schmid AC, Mirabelli M, Pomeranz KM, Erneux C, Lam EW, Vilar R, Woscholski Ret al., 2006, A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN), ACS Chem.Biol., Vol: 1, Pages: 780-790

Phosphatase and tensin homologue deleted on chromosome 10 (PTEN), a phosphoinositide 3-phosphatase, is an important regulator of insulin-dependent signaling. The loss or impairment of PTEN results in an antidiabetic impact, which led to the suggestion that PTEN could be an important target for drugs against type II diabetes. Here we report the design and validation of a small- molecule inhibitor of PTEN. Compared with other cysteine-based phosphatases, PTEN has a much wider active site cleft enabling it to bind the PtdIns(3,4,5)P3 substrate. We have exploited this feature in the design of vanadate scaffolds complexed to a range of different organic ligands, some of which show potent inhibitory activity. A vanadyl complexed to hydroxypicolinic acid was found to be a highly potent and specific inhibitor of PTEN that increases cellular PtdIns(3,4,5)P3 levels, phosphorylation of Akt, and glucose uptake in adipocytes at nanomolar concentrations. The findings presented here demonstrate the applicability of a novel and specific chemical inhibitor against PTEN in research and drug development

Journal article

Gimeno N, Vilar R, 2006, Anions as templates in coordination and supramolecular chemistry, COORDINATION CHEMISTRY REVIEWS, Vol: 250, Pages: 3161-3189, ISSN: 0010-8545

Journal article

Burkill HA, Vilar R, White AJP, 2006, Synthesis of a series of ruthenium and rhodium complexes with tridentate pyridine-based ligands containing hydrogen bonding groups, INORGANICA CHIMICA ACTA, Vol: 359, Pages: 3709-3722, ISSN: 0020-1693

Journal article

Christmann U, Pantazis DA, Benet-Buchholz J, McGrady JE, Maseras F, Vilar Ret al., 2006, Experimental and theoretical investigations of new dinuclear palladium complexes as precatalysts for the amination of aryl chlorides, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol: 128, Pages: 6376-6390, ISSN: 0002-7863

Journal article

Reed JE, Arnal AA, Neidle S, Vilar Ret al., 2006, Stabilization of G-quadruplex DNA and inhibition of telomerase activity by square-planar nickel(II) complexes, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol: 128, Pages: 5992-5993, ISSN: 0002-7863

Journal article

Diaz P, Benet-Buchholz J, Vilar R, White AJPet al., 2006, Anion influence on the structures of a series of copper(II) metal-organic frameworks, INORGANIC CHEMISTRY, Vol: 45, Pages: 1617-1626, ISSN: 0020-1669

Journal article

Miller PW, Long NJ, de Mello AJ, Vilar R, Passchier J, Gee Aet al., 2006, Rapid formation of amides via carbonylative coupling reactions using a microfluidic device, CHEMICAL COMMUNICATIONS, Pages: 546-548, ISSN: 1359-7345

Journal article

Miller PW, Long NJ, De Mello AJ, Vilar R, Passchier J, Gee Aet al., 2006, Rapid gas-liquid palladium carbonylative cross-coupling reactions using a glass fabricated microfluidic chip for applications in<sup>11</sup>C- radiolabelling, Pages: 876-878

A series of gas-liquid palladium catalysed carbonylative cross-coupling reactions, forming secondary amides, were carried out using a glass fabricated microfluidic device. Improved yields from the microreactions were obtained in short reaction times (< 2 min) and were higher in all cases when compared to their corresponding batch reactions. We are currently in the process of applying our reaction set-up to [11C]CO radiolabelling to be used in PET (Positron Emission Tomography) imaging. © 2006 Society for Chemistry and Micro-Nano Systems.

Conference paper

Reed JE, Arola A, Vilar R, Neidle Set al., 2005, Metal-containing stabilisers of G-quadruplex DNA as telomerase inhibitors., 17th EORTC/AACR/NCI International Conference on Molecular Targets and Cancer Therapeutics, Publisher: AMER ASSOC CANCER RESEARCH, Pages: 9051S-9051S, ISSN: 1078-0432

Conference paper

Owen GR, Burkill HA, Vilar R, White AJP, Williams DJet al., 2005, Palladium complexes containing ligands with hydrogen-bonding functionalities. Reactivity and catalytic studies with CO and olefins, Journal of Organometallic Chemistry, Vol: 690, Pages: 5113-5124, ISSN: 0022-328X

Journal article

Formentin P, Gimeno N, Steinke JHG, Vilar Ret al., 2005, Reactivity of Grubbs' catalysts with urea- and amide-substituted olefins. Metathesis and isomerization, JOURNAL OF ORGANIC CHEMISTRY, Vol: 70, Pages: 8235-8238, ISSN: 0022-3263

Journal article

Coronado E, Galan-Mascaros JR, Marti-Gastaldo C, Palomares E, Durrant JR, Vilar R, Gratzel M, Nazeeruddin MKet al., 2005, Reversible colorimetric probes for mercury sensing, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol: 127, Pages: 12351-12356, ISSN: 0002-7863

Journal article

Rosivatz E, Vilar R, Woscholski R, 2005, Imaging of PKB phosphorylation as an in vivo readout for PTEN inhibition studies, IUBMB 50th Anniversary Symposium, Publisher: BLACKWELL PUBLISHING, Pages: 313-313, ISSN: 1742-464X

Conference paper

Burkill HA, Robertson NR, Vilar R, White AJP, Williams DJet al., 2005, Synthesis, structural characterization, and magnetic studies of polynuclear iron complexes with a new disubstituted pyridine ligand, INORGANIC CHEMISTRY, Vol: 44, Pages: 3337-3346, ISSN: 0020-1669

Journal article

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