Imperial College London

Prof. Ramon Vilar

Faculty of Natural SciencesDepartment of Chemistry

Professor of Medicinal Inorganic Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 1967r.vilar Website

 
 
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Location

 

301HMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@inbook{Gonzalez-Garcia:2017:10.1016/B978-0-12-409547-2.12549-1,
author = {Gonzalez-Garcia, J and Vilar, R},
booktitle = {Comprehensive Supramolecular Chemistry II},
doi = {10.1016/B978-0-12-409547-2.12549-1},
pages = {39--70},
title = {Supramolecular Principles for Small Molecule Binding to DNA Structures},
url = {http://dx.doi.org/10.1016/B978-0-12-409547-2.12549-1},
year = {2017}
}

RIS format (EndNote, RefMan)

TY  - CHAP
AB - © 2017 Elsevier Ltd. All rights reserved. Small molecules that interact with deoxyribonucleic acid (DNA) are important for the development of drugs and biomolecular tools. There are indeed several drugs in clinical use whose main biological target is DNA; likewise, a range of optical probes that bind to DNA are routinely used to study biological systems. Therefore, understanding, rationalizing, and predicting the interaction of small molecules with DNA is an important area of research. This article provides an overview of the key noncovalent interactions used by small organic and metal-organic molecules to bind to DNA. The first part of the article provides an overview of the different DNA structures/topologies and the key supramolecular interactions they display. The subsequent sections of the article have been divided by the type of DNA structure that is being targeted as well as by the binding mode displayed by the molecules discussed. Rather than providing an exhaustive and comprehensive review of the very extensive literature, the main aim of this article is to highlight the key supramolecular principles that drive these interactions.
AU - Gonzalez-Garcia,J
AU - Vilar,R
DO - 10.1016/B978-0-12-409547-2.12549-1
EP - 70
PY - 2017///
SN - 9780128031995
SP - 39
TI - Supramolecular Principles for Small Molecule Binding to DNA Structures
T1 - Comprehensive Supramolecular Chemistry II
UR - http://dx.doi.org/10.1016/B978-0-12-409547-2.12549-1
ER -