Imperial College London

Prof. Ramon Vilar

Faculty of Natural SciencesDepartment of Chemistry

Professor of Medicinal Inorganic Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 1967r.vilar Website

 
 
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Location

 

301HMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Pont:2018:10.1002/chem.201802077,
author = {Pont, I and González-García, J and Inclán, M and Reynolds, M and Delgado-Pinar, E and Albelda, MT and Vilar, R and García-España, EV},
doi = {10.1002/chem.201802077},
journal = {Chemistry - A European Journal},
pages = {10850--10858},
title = {Aza-macrocyclic triphenylamine ligands for G-quadruplex recognition},
url = {http://dx.doi.org/10.1002/chem.201802077},
volume = {24},
year = {2018}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - A new series of triphenylamine-based ligands with one (TPA1PY), two (TPA2PY) or three pending aza-macrocycle(s) (TPA3PY) have been synthesised and studied by means of pH-metric titrations, UV/Vis spectroscopy and fluorescence experiments. The affinity of these ligands for G-quadruplex (G4) DNA and its selectivity over duplex DNA were investigated by FRET melting assays, fluorimetric titrations and circular dichroism (CD) spectroscopy. Interestingly, the interaction of the bi- and specially the tri-branched ligand with G4 leads to a very intense red-shifted fluorescence emission band which may be associated with intermolecular aggregation between the molecule and the DNA. This light-up effect allows the application of the ligands as fluorescence probes to selectivity detect G4.
AU - Pont,I
AU - González-García,J
AU - Inclán,M
AU - Reynolds,M
AU - Delgado-Pinar,E
AU - Albelda,MT
AU - Vilar,R
AU - García-España,EV
DO - 10.1002/chem.201802077
EP - 10858
PY - 2018///
SN - 0947-6539
SP - 10850
TI - Aza-macrocyclic triphenylamine ligands for G-quadruplex recognition
T2 - Chemistry - A European Journal
UR - http://dx.doi.org/10.1002/chem.201802077
UR - https://www.ncbi.nlm.nih.gov/pubmed/29768679
UR - http://hdl.handle.net/10044/1/60205
VL - 24
ER -