Imperial College London

Prof. Ramon Vilar

Faculty of Natural SciencesDepartment of Chemistry

Professor of Medicinal Inorganic Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 1967r.vilar Website

 
 
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Location

 

301HMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@inbook{Vilar:2018:10.1515/9783110470734-012,
author = {Vilar, R},
booktitle = {Metallo-Drugs: Development and Action of Anticancer Agents},
doi = {10.1515/9783110470734-012},
pages = {325--349},
title = {Nucleic acid quadruplexes and metallo-drugs},
url = {http://dx.doi.org/10.1515/9783110470734-012},
year = {2018}
}

RIS format (EndNote, RefMan)

TY  - CHAP
AB - © Walter de Gruyter GmbH, Berlin, Germany 2018. Guanine-rich sequences of DNA can readily fold into tetra-stranded helical assemblies known as G-quadruplexes (G4s). It has been proposed that these structures play important biological roles in transcription, translation, replication, and telomere maintenance. Therefore, over the past 20 years they have been investigated as potential drug targets for small molecules including metal complexes. This chapter provides an overview of the different classes of metal complexes as G4-binders and discusses the application of these species as optical probes for G-quadruplexes as well as metallo-drugs.
AU - Vilar,R
DO - 10.1515/9783110470734-012
EP - 349
PY - 2018///
SN - 9783110469844
SP - 325
TI - Nucleic acid quadruplexes and metallo-drugs
T1 - Metallo-Drugs: Development and Action of Anticancer Agents
UR - http://dx.doi.org/10.1515/9783110470734-012
ER -