Imperial College London

Prof. Ramon Vilar

Faculty of Natural SciencesDepartment of Chemistry

Professor of Medicinal Inorganic Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 1967r.vilar Website

 
 
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Location

 

301HMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ferraro:2018:10.2217/nnm-2018-0259,
author = {Ferraro, G and Pica, A and Petruk, G and Pane, F and Amoresano, A and Cilibrizzi, A and Vilar, R and Monti, DM and Merlino, A},
doi = {10.2217/nnm-2018-0259},
journal = {Nanomedicine},
pages = {2995--3007},
title = {Preparation, structure, cytotoxicity and mechanism of action of ferritin-Pt(II) terpyridine compound nanocomposites},
url = {http://dx.doi.org/10.2217/nnm-2018-0259},
volume = {13},
year = {2018}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Aim: A Pt(II)-terpyridine compound, bearing two piperidine substituents at positions 2 and 2′ of the terpyridine ligand (1), is highly cytotoxic and shows a mechanism of action distinct from cisplatin. 1 has been incorporated within the ferritin nanocage (AFt). Materials & methods: Spectroscopic and crystallographic data of the Pt(II)–AFt nanocomposite have been collected and in vitro anticancer activity has been explored using cancer cells. Results: Pt(II)-containing fragments bind His49, His114 and His132. Pt(II)–AFt nanocomposite is less cytotoxic than 1, but it is more toxic than cisplatin at high concentrations. The Pt(II)–AFt nanocomposite triggers necrosis in cancer cells, as free 1 does. Conclusion: Pt(II)–AFt nanocomposites are promising vehicles to deliver Pt-based drugs to cancer cells.
AU - Ferraro,G
AU - Pica,A
AU - Petruk,G
AU - Pane,F
AU - Amoresano,A
AU - Cilibrizzi,A
AU - Vilar,R
AU - Monti,DM
AU - Merlino,A
DO - 10.2217/nnm-2018-0259
EP - 3007
PY - 2018///
SN - 1743-5889
SP - 2995
TI - Preparation, structure, cytotoxicity and mechanism of action of ferritin-Pt(II) terpyridine compound nanocomposites
T2 - Nanomedicine
UR - http://dx.doi.org/10.2217/nnm-2018-0259
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000453001300004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - http://hdl.handle.net/10044/1/65364
VL - 13
ER -