Imperial College London

Prof. Ramon Vilar

Faculty of Natural SciencesDepartment of Chemistry

Professor of Medicinal Inorganic Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 1967r.vilar Website

 
 
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Location

 

301HMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Vilar:2018:10.1515/9783110470734-018,
author = {Vilar, R},
doi = {10.1515/9783110470734-018},
journal = {Met Ions Life Sci},
title = {Nucleic Acid Quadruplexes and Metallo-Drugs.},
url = {http://dx.doi.org/10.1515/9783110470734-018},
volume = {18},
year = {2018}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Guanine-rich sequences of DNA can readily fold into tetra-stranded helical assemblies known as G-quadruplexes (G4s). It has been proposed that these structures play important biological roles in transcription, translation, replication, and telomere maintenance. Therefore, over the past 20 years they have been investigated as potential drug targets for small molecules including metal complexes. This chapter provides an overview of the different classes of metal complexes as G4-binders and discusses the application of these species as optical probes for G-quadruplexes as well as metallo-drugs.
AU - Vilar,R
DO - 10.1515/9783110470734-018
PY - 2018///
SN - 1559-0836
TI - Nucleic Acid Quadruplexes and Metallo-Drugs.
T2 - Met Ions Life Sci
UR - http://dx.doi.org/10.1515/9783110470734-018
UR - https://www.ncbi.nlm.nih.gov/pubmed/29394031
VL - 18
ER -