Imperial College London

Prof. Ramon Vilar

Faculty of Natural SciencesDepartment of Chemistry

Professor of Medicinal Inorganic Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 1967r.vilar Website

 
 
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Location

 

301HMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Zhou:2017:10.1002/chem.201700276,
author = {Zhou, CQ and Liao, TC and Li, ZQ and Gonzalez, Garcia J and Reynolds, M and Zou, M and Vilar, Compte R},
doi = {10.1002/chem.201700276},
journal = {Chemistry - A European Journal},
pages = {4713--4722},
title = {Di-nickel-salphen complexes as binders of human telomeric dimeric G-quadruplexes},
url = {http://dx.doi.org/10.1002/chem.201700276},
volume = {23},
year = {2017}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Three new polyether-tethered di-nickel-salphen complexes (2a-c) have been synthesized and fully characterized by NMR spectroscopy, mass spectrometry and elemental analyses. The binding affinity and selectivity of these complexes and of the parent mono-nickel complex (1) towards dimeric quadruplex DNA have been determined by UV-Vis titrations, fluorescence spectroscopy, CD spectroscopy and electrophoresis. These studies have shown that the di-nickel-salphen complex with the longest polyether linker (2c) has higher binding affinity and selectivity towards dimeric quadruplexes (over monomeric quadruplexes) than the di-nickel-salphen complexes with the shorter polyether linkers (2a and 2b). Complex 2c also has higher selectivity towards human telomeric dimeric quadruplexes with one TTA linker than the monometallic complex 1. Based on the spectroscopic data, a possible binding mode between complex 2c and the dimeric G-quadruplex DNA under study is proposed.
AU - Zhou,CQ
AU - Liao,TC
AU - Li,ZQ
AU - Gonzalez,Garcia J
AU - Reynolds,M
AU - Zou,M
AU - Vilar,Compte R
DO - 10.1002/chem.201700276
EP - 4722
PY - 2017///
SN - 0947-6539
SP - 4713
TI - Di-nickel-salphen complexes as binders of human telomeric dimeric G-quadruplexes
T2 - Chemistry - A European Journal
UR - http://dx.doi.org/10.1002/chem.201700276
UR - http://hdl.handle.net/10044/1/44789
VL - 23
ER -