Imperial College London

Prof. Ramon Vilar

Faculty of Natural SciencesDepartment of Chemistry

Professor of Medicinal Inorganic Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 1967r.vilar Website

 
 
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Location

 

301HMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Vilar:2017:10.1002/anie.201709968,
author = {Vilar, R and Bandeira, S and Gonzalez, Garcia J and Pensa, E and Albrecht, T},
doi = {10.1002/anie.201709968},
journal = {Angewandte Chemie International Edition},
pages = {310--313},
title = {A redox-activated G-quadruplex DNA binder based on a platinum(IV)-salphen complex.},
url = {http://dx.doi.org/10.1002/anie.201709968},
volume = {57},
year = {2017}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - There has been increasing interest in the development of small molecules that can selectively bind to G-quadruplex DNA structures. The latter have been associated to a number of key biological processes and therefore are proposed to be potential targets for drug development. In this paper we report the first example of a reduction-activated G-quadruplex DNA binder. We show that a new octahedral platinum(IV)-salphen complex does not interact with DNA in aqueous media at pH 7.4; however, upon addition of bio-reductants such as ascorbic acid or glutathione, the compound readily reduces to the corresponding square planar platinum(II) complex. In contrast to the parent platinum(IV) complex, the in situ generated platinum(II) complex binds to HTelo and c-Myc G-quadruplex DNA with affinity constants up to 106 M-1.
AU - Vilar,R
AU - Bandeira,S
AU - Gonzalez,Garcia J
AU - Pensa,E
AU - Albrecht,T
DO - 10.1002/anie.201709968
EP - 313
PY - 2017///
SN - 1521-3757
SP - 310
TI - A redox-activated G-quadruplex DNA binder based on a platinum(IV)-salphen complex.
T2 - Angewandte Chemie International Edition
UR - http://dx.doi.org/10.1002/anie.201709968
UR - http://hdl.handle.net/10044/1/54030
VL - 57
ER -