Imperial College London
Alternate

Prof. Ramon Vilar

Faculty of Natural Sciences, Department of Chemistry

Professor of Medicinal Inorganic Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 1967r.vilar Website

 
 
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Location

 

301HMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cowell:2017:10.1039/C7DT03108D,
author = {Cowell, S and Carroll, L and Lavdas, I and Aboagye, E and Vilar, Compte R},
doi = {10.1039/C7DT03108D},
journal = {Dalton Transactions},
pages = {1530--1534},
title = {Towards an MMP-2-activated molecular agent for cancer imaging},
url = {http://dx.doi.org/10.1039/C7DT03108D},
volume = {47},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Matrix metalloproteinases (MMPs) have been identified as biomarkers for cancer, offering prognostic potential; however, non-invasive detection protocols are currently lacking. Herein, we describe the synthesis of a DOTA-containing peptide sequence that can be radiolabelled easily with 68Gallium or can be incorporated with gadolinium for possible MRI applications with clear selectivity for MMP-2 over other members of the MMP family, giving MMP-2 selective cleavage of the labelled peptides.
AU  - Cowell,S
AU  - Carroll,L
AU  - Lavdas,I
AU  - Aboagye,E
AU  - Vilar,Compte R
DO  - 10.1039/C7DT03108D
EP  - 1534
PY  - 2017///
SN  - 1477-9234
SP  - 1530
TI  - Towards an MMP-2-activated molecular agent for cancer imaging
T2  - Dalton Transactions
UR  - http://dx.doi.org/10.1039/C7DT03108D
UR  - http://hdl.handle.net/10044/1/55308
VL  - 47
ER  -
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