164 results found
Ferraro G, Pica A, Petruk G, et al., 2018, Preparation, structure, cytotoxicity and mechanism of action of ferritin-Pt(II) terpyridine compound nanocomposites, NANOMEDICINE, Vol: 13, Pages: 2995-3007, ISSN: 1743-5889
Leczkowska A, Gonzalez-Garcia J, Perez-Arnaiz C, et al., 2018, Binding Studies of Metal-Salphen and Metal-Bipyridine Complexes towards G-Quadruplex DNA, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 24, Pages: 11785-11794, ISSN: 0947-6539
Pont I, Gonzalez-Garcia J, Inclan M, et al., 2018, Aza-Macrocyclic Triphenylamine Ligands for G-Quadruplex Recognition, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 24, Pages: 10850-10858, ISSN: 0947-6539
Ferraro G, Marzo T, Infrasca T, et al., 2018, A case of extensive protein platination: the reaction of lysozyme with a Pt(II)-terpyridine complex, DALTON TRANSACTIONS, Vol: 47, Pages: 8716-8723, ISSN: 1477-9226
Chan TG, Morse SV, Copping MJ, et al., 2018, Targeted Delivery of DNA-Au Nanoparticles across the Blood-Brain Barrier Using Focused Ultrasound, CHEMMEDCHEM, Vol: 13, Pages: 1311-1314, ISSN: 1860-7179
Rakers V, Cadinu P, Edel JB, et al., 2018, Development of microfluidic platforms for the synthesis of metal complexes and evaluation of their DNA affinity using online FRET melting assays, CHEMICAL SCIENCE, Vol: 9, Pages: 3459-3469, ISSN: 2041-6520
Cowell S, Carroll L, Lavdas I, et al., 2018, Towards an MMP-2-activated molecular agent for cancer imaging, DALTON TRANSACTIONS, Vol: 47, Pages: 1530-1534, ISSN: 1477-9226
, 2018, Nucleic acid quadruplexes and metallo-drugs, Metallo-Drugs: Development and Action of Anticancer Agents, Pages: 325-349, ISBN: 9783110470734
© Walter de Gruyter GmbH, Berlin, Germany 2018. Guanine-rich sequences of DNA can readily fold into tetra-stranded helical assemblies known as G-quadruplexes (G4s). It has been proposed that these structures play important biological roles in transcription, translation, replication, and telomere maintenance. Therefore, over the past 20 years they have been investigated as potential drug targets for small molecules including metal complexes. This chapter provides an overview of the different classes of metal complexes as G4-binders and discusses the application of these species as optical probes for G-quadruplexes as well as metallo-drugs.
Bandeira S, Gonzalez-Garcia J, Pensa E, et al., 2018, A Redox-Activated G-Quadruplex DNA Binder Based on a Platinum(IV)-Salphen Complex, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 57, Pages: 310-313, ISSN: 1433-7851
Cilibrizzi A, Terenghi M, Fedorova M, et al., 2017, Small-molecule optical probes for cell imaging of protein sulfenylation and their application to monitor cisplatin induced protein oxidation, SENSORS AND ACTUATORS B-CHEMICAL, Vol: 248, Pages: 437-446, ISSN: 0925-4005
Pyne ALB, Hoogenboom BW, Vilar R, et al., 2017, Visualisation of DNA conformational changes in situ at nanometre resolution, 19th IUPAB Congress / 11th EBSA Congress, Publisher: SPRINGER, Pages: S369-S369, ISSN: 0175-7571
, 2017, Supramolecular Principles for Small Molecule Binding to DNA Structures, Comprehensive Supramolecular Chemistry II, Pages: 39-70, ISBN: 9780128031988
© 2017 Elsevier Ltd. All rights reserved. Small molecules that interact with deoxyribonucleic acid (DNA) are important for the development of drugs and biomolecular tools. There are indeed several drugs in clinical use whose main biological target is DNA; likewise, a range of optical probes that bind to DNA are routinely used to study biological systems. Therefore, understanding, rationalizing, and predicting the interaction of small molecules with DNA is an important area of research. This article provides an overview of the key noncovalent interactions used by small organic and metal-organic molecules to bind to DNA. The first part of the article provides an overview of the different DNA structures/topologies and the key supramolecular interactions they display. The subsequent sections of the article have been divided by the type of DNA structure that is being targeted as well as by the binding mode displayed by the molecules discussed. Rather than providing an exhaustive and comprehensive review of the very extensive literature, the main aim of this article is to highlight the key supramolecular principles that drive these interactions.
Cilibrizzi A, Fedorova M, Collins J, et al., 2017, A tri-functional vanadium(IV) complex to detect cysteine oxidation, DALTON TRANSACTIONS, Vol: 46, Pages: 6994-7004, ISSN: 1477-9226
Zhou C-Q, Liao T-C, Li Z-Q, et al., 2017, Dinickel-Salphen Complexes as Binders of Human Telomeric Dimeric G-Quadruplexes, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 23, Pages: 4713-4722, ISSN: 0947-6539
Markovic T, Manzoor S, Humphreys-Williams E, et al., 2017, Experimental Determination of Zinc Isotope Fractionation in Complexes with the Phytosiderophore 2 '-Deoxymugeneic Acid (DMA) and Its Structural Analogues, and Implications for Plant Uptake Mechanisms, ENVIRONMENTAL SCIENCE & TECHNOLOGY, Vol: 51, Pages: 98-107, ISSN: 0013-936X
Kotar A, Wang B, Shivalingam A, et al., 2016, NMR Structure of a Triangulenium-Based Long-Lived Fluorescence Probe Bound to a G-Quadruplex, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 55, Pages: 12508-12511, ISSN: 1433-7851
Vilar Compte R, Klejevskaja B, Pyne LBA, et al., 2016, Studies of G-quadruplexes formed within self-assembled DNA mini-circles, Chemical Communications (London), Vol: 52, Pages: 12454-12457, ISSN: 0009-241X
We have developed self-assembled DNA mini-circles that contain a G-quadruplex-forming sequence from the c-Myc oncogene promoter and demonstrate by FRET that the G-quadruplex unfolding kinetics are 10-fold slower than for the simpler 24-mer G-quadruplex that is commonly used for FRET experiments.
Gama S, Rodrigues I, Mendes F, et al., 2016, Anthracene-terpyridine metal complexes as new G-quadruplex DNA binders, JOURNAL OF INORGANIC BIOCHEMISTRY, Vol: 160, Pages: 275-286, ISSN: 0162-0134
Shivalingam A, Vysniauskas A, Albrecht T, et al., 2016, Trianguleniums as Optical Probes for G-Quadruplexes: APhotophysical, Electrochemical, and Computational Study, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 22, Pages: 4129-4139, ISSN: 0947-6539
Ang DL, Harper BWJ, Cubo L, et al., 2016, Quadruplex DNA-Stabilising Dinuclear Platinum(II) Terpyridine Complexes with Flexible Linkers, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 22, Pages: 2317-2325, ISSN: 0947-6539
Ang DL, Harper BWJ, Cubo L, et al., 2016, Back Cover: Quadruplex DNA-Stabilising Dinuclear Platinum(II) Terpyridine Complexes with Flexible Linkers (Chem. Eur. J. 7/2016), Chemistry - A European Journal, Vol: 22, Pages: 2540-2540, ISSN: 0947-6539
Collins J, Cilibrizzi A, Fedorova M, et al., 2016, Vanadyl complexes with dansyl-labelled dipicolinic acid ligands: synthesis, phosphatase inhibition activity and cellular uptake studies, DALTON TRANSACTIONS, Vol: 45, Pages: 7104-7113, ISSN: 1477-9226
Turek VA, Francescato Y, Cadinu P, et al., 2016, Self-Assembled Spherical Supercluster Metamaterials from Nanoscale Building Blocks, ACS PHOTONICS, Vol: 3, Pages: 35-42, ISSN: 2330-4022
Wilson N, Mak LH, Cilibrizzi A, et al., 2016, A lipophilic copper(II) complex as an optical probe for intracellular detection of NO, DALTON TRANSACTIONS, Vol: 45, Pages: 18177-18182, ISSN: 1477-9226
Mion G, Gianferrara T, Bergamo A, et al., 2015, Phototoxic Activity and DNA Interactions of Water-Soluble Porphyrins and Their Rhenium(I) Conjugates, CHEMMEDCHEM, Vol: 10, Pages: 1901-1914, ISSN: 1860-7179
Shivalingam A, Izquierdo MA, Le Marois A, et al., 2015, The interactions between a small molecule and G-quadruplexes are visualized by fluorescence lifetime imaging microscopy, NATURE COMMUNICATIONS, Vol: 6, ISSN: 2041-1723
Mendoza C, Jansat S, Vilar R, et al., 2015, Clickable complexing agents: functional crown ethers for immobilisation onto polymers and magnetic nanoparticles, RSC ADVANCES, Vol: 5, Pages: 87352-87363, ISSN: 2046-2069
Moffat CD, Weiss DJ, Shivalingam A, et al., 2014, Molecular Recognition and Scavenging of Arsenate from Aqueous Solution Using Dimetallic Receptors, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 20, Pages: 17168-17177, ISSN: 0947-6539
Stafford VS, Suntharalingam K, Shivalingam A, et al., 2014, Syntheses of polypyridyl metal complexes and studies of their interaction with quadruplex DNA, Dalton Transactions, Vol: 44, Pages: 3686-3700, ISSN: 1477-9226
A series of mono- and bi-metallic metal complexes (with CuII, PtII and ZnII) with substituted polypyridylligands have been prepared and their binding affinities towards quadruplex (c-Myc and human telomeric)and duplex DNA (ds26 and calf thymus) determined using fluorescent indicator displacement (FID) assaysand UV/vis spectroscopic titrations. These studies have shown that the number of aromatic rings andnumber/position of cyclic amine substituents on the ligands, play an important role in defining the DNAbinding abilities of the resulting metal complexes. We also show that bi-metallic complexes preparedusing a novel terpyridine-cyclen ligand have higher affinity towards G-quadruplex DNA as compared totheir mono-metallic counterparts. Cytotoxicity assays were carried out for all the new complexes againstan osteosarcoma cancer cell line (U2OS) as well as a normal fibroblast cell line (GM05757). Several ofthese compounds displayed cytotoxicity similar to that of cisplatin.
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