Imperial College London

Prof. Ramon Vilar

Faculty of Natural SciencesDepartment of Chemistry

Professor of Medicinal Inorganic Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 1967r.vilar Website

 
 
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Location

 

RCS1-315ChemistrySouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

158 results found

Bandeira S, Gonzalez-Garcia J, Pensa E, Albrecht T, Vilar Ret al., 2018, A Redox-Activated G-Quadruplex DNA Binder Based on a Platinum(IV)-Salphen Complex, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 57, Pages: 310-313, ISSN: 1433-7851

JOURNAL ARTICLE

Cowell S, Carroll L, Lavdas I, Aboagye EO, Vilar Ret al., 2018, Towards an MMP-2-activated molecular agent for cancer imaging, DALTON TRANSACTIONS, Vol: 47, Pages: 1530-1534, ISSN: 1477-9226

JOURNAL ARTICLE

Rakers V, Cadinu P, Edel JB, Vilar Ret al., 2018, Development of microfluidic platforms for the synthesis of metal complexes and evaluation of their DNA affinity using online FRET melting assays, CHEMICAL SCIENCE, Vol: 9, Pages: 3459-3469, ISSN: 2041-6520

JOURNAL ARTICLE

Cilibrizzi A, Fedorova M, Collins J, Leatherbarrow R, Woscholski R, Vilar Ret al., 2017, A tri-functional vanadium(IV) complex to detect cysteine oxidation, DALTON TRANSACTIONS, Vol: 46, Pages: 6994-7004, ISSN: 1477-9226

JOURNAL ARTICLE

Cilibrizzi A, Terenghi M, Fedorova M, Woscholski R, Klug D, Vilar Ret al., 2017, Small-molecule optical probes for cell imaging of protein sulfenylation and their application to monitor cisplatin induced protein oxidation, SENSORS AND ACTUATORS B-CHEMICAL, Vol: 248, Pages: 437-446, ISSN: 0925-4005

JOURNAL ARTICLE

Gonzalez-Garcia J, Vilar R, 2017, Supramolecular Principles for Small Molecule Binding to DNA Structures, Comprehensive Supramolecular Chemistry II, Pages: 39-70, ISBN: 9780128031988

© 2017 Elsevier Ltd. All rights reserved. Small molecules that interact with deoxyribonucleic acid (DNA) are important for the development of drugs and biomolecular tools. There are indeed several drugs in clinical use whose main biological target is DNA; likewise, a range of optical probes that bind to DNA are routinely used to study biological systems. Therefore, understanding, rationalizing, and predicting the interaction of small molecules with DNA is an important area of research. This article provides an overview of the key noncovalent interactions used by small organic and metal-organic molecules to bind to DNA. The first part of the article provides an overview of the different DNA structures/topologies and the key supramolecular interactions they display. The subsequent sections of the article have been divided by the type of DNA structure that is being targeted as well as by the binding mode displayed by the molecules discussed. Rather than providing an exhaustive and comprehensive review of the very extensive literature, the main aim of this article is to highlight the key supramolecular principles that drive these interactions.

BOOK CHAPTER

Markovic T, Manzoor S, Humphreys-Williams E, Kirk GJD, Vilar R, Weiss DJet al., 2017, Experimental Determination of Zinc Isotope Fractionation in Complexes with the Phytosiderophore 2 '-Deoxymugeneic Acid (DMA) and Its Structural Analogues, and Implications for Plant Uptake Mechanisms, ENVIRONMENTAL SCIENCE & TECHNOLOGY, Vol: 51, Pages: 98-107, ISSN: 0013-936X

JOURNAL ARTICLE

Pyne ALB, Hoogenboom BW, Vilar R, Maxwell Aet al., 2017, Visualisation of DNA conformational changes in situ at nanometre resolution, 19th IUPAB Congress / 11th EBSA Congress, Publisher: SPRINGER, Pages: S369-S369, ISSN: 0175-7571

CONFERENCE PAPER

Zhou C-Q, Liao T-C, Li Z-Q, Gonzalez-Garcia J, Reynolds M, Zou M, Vilar Ret al., 2017, Dinickel-Salphen Complexes as Binders of Human Telomeric Dimeric G-Quadruplexes, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 23, Pages: 4713-4722, ISSN: 0947-6539

JOURNAL ARTICLE

Ang DL, Harper BWJ, Cubo L, Mendoza O, Vilar R, Aldrich-Wright Jet al., 2016, Quadruplex DNA-Stabilising Dinuclear Platinum(II) Terpyridine Complexes with Flexible Linkers, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 22, Pages: 2317-2325, ISSN: 0947-6539

JOURNAL ARTICLE

Ang DL, Harper BWJ, Cubo L, Mendoza O, Vilar R, Aldrich-Wright Jet al., 2016, Back Cover: Quadruplex DNA-Stabilising Dinuclear Platinum(II) Terpyridine Complexes with Flexible Linkers (Chem. Eur. J. 7/2016), Chemistry - A European Journal, Vol: 22, Pages: 2540-2540, ISSN: 0947-6539

JOURNAL ARTICLE

Collins J, Cilibrizzi A, Fedorova M, Whyte G, Mak LH, Guterman I, Leatherbarrow R, Woscholski R, Vilar Ret al., 2016, Vanadyl complexes with dansyl-labelled dipicolinic acid ligands: synthesis, phosphatase inhibition activity and cellular uptake studies, DALTON TRANSACTIONS, Vol: 45, Pages: 7104-7113, ISSN: 1477-9226

JOURNAL ARTICLE

Gama S, Rodrigues I, Mendes F, Santos IC, Gabano E, Klejevskaja B, Gonzalez-Garcia J, Ravera M, Vilar R, Paulo Aet al., 2016, Anthracene-terpyridine metal complexes as new G-quadruplex DNA binders, JOURNAL OF INORGANIC BIOCHEMISTRY, Vol: 160, Pages: 275-286, ISSN: 0162-0134

JOURNAL ARTICLE

Kotar A, Wang B, Shivalingam A, Gonzalez-Garcia J, Vilar R, Plavec Jet al., 2016, NMR Structure of a Triangulenium-Based Long-Lived Fluorescence Probe Bound to a G-Quadruplex, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 55, Pages: 12508-12511, ISSN: 1433-7851

JOURNAL ARTICLE

Shivalingam A, Vysniauskas A, Albrecht T, White AJP, Kuimova MK, Vilar Ret al., 2016, Trianguleniums as Optical Probes for G-Quadruplexes: APhotophysical, Electrochemical, and Computational Study, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 22, Pages: 4129-4139, ISSN: 0947-6539

JOURNAL ARTICLE

Turek VA, Francescato Y, Cadinu P, Crick CR, Elliott L, Chen Y, Urland V, Ivanov AP, Velleman L, Hong M, Vilar R, Maier SA, Giannini V, Edel JBet al., 2016, Self-Assembled Spherical Supercluster Metamaterials from Nanoscale Building Blocks, ACS PHOTONICS, Vol: 3, Pages: 35-42, ISSN: 2330-4022

JOURNAL ARTICLE

Vilar Compte R, Klejevskaja B, Pyne LBA, Reynolds M, Shivalingam A, Thorogate R, Hoogenboom BW, Ying Let al., 2016, Studies of G-quadruplexes formed within self-assembled DNA mini-circles, Chemical Communications (London), Vol: 52, Pages: 12454-12457, ISSN: 0009-241X

We have developed self-assembled DNA mini-circles that contain a G-quadruplex-forming sequence from the c-Myc oncogene promoter and demonstrate by FRET that the G-quadruplex unfolding kinetics are 10-fold slower than for the simpler 24-mer G-quadruplex that is commonly used for FRET experiments.

JOURNAL ARTICLE

Wilson N, Mak LH, Cilibrizzi A, Gee AD, Long NJ, Woscholski R, Vilar Ret al., 2016, A lipophilic copper(II) complex as an optical probe for intracellular detection of NO, DALTON TRANSACTIONS, Vol: 45, Pages: 18177-18182, ISSN: 1477-9226

JOURNAL ARTICLE

Mendoza C, Jansat S, Vilar R, Pericas MAet al., 2015, Clickable complexing agents: functional crown ethers for immobilisation onto polymers and magnetic nanoparticles, RSC ADVANCES, Vol: 5, Pages: 87352-87363, ISSN: 2046-2069

JOURNAL ARTICLE

Mion G, Gianferrara T, Bergamo A, Gasser G, Pierroz V, Rubbiani R, Vilar R, Leczkowska A, Alessio Eet al., 2015, Phototoxic Activity and DNA Interactions of Water-Soluble Porphyrins and Their Rhenium(I) Conjugates, CHEMMEDCHEM, Vol: 10, Pages: 1901-1914, ISSN: 1860-7179

JOURNAL ARTICLE

Shivalingam A, Izquierdo MA, Le Marois A, Vysniauskas A, Suhling K, Kuimova MK, Vilar Ret al., 2015, The interactions between a small molecule and G-quadruplexes are visualized by fluorescence lifetime imaging microscopy, NATURE COMMUNICATIONS, Vol: 6, ISSN: 2041-1723

JOURNAL ARTICLE

Ali SMH, Yan Y-K, Lee PPF, Khong KZX, Sk MA, Lim KH, Klejevskaja B, Vilar Ret al., 2014, Copper(II) complexes of substituted salicylaldehyde dibenzyl semicarbazones: synthesis, cytotoxicity and interaction with quadruplex DNA, DALTON TRANSACTIONS, Vol: 43, Pages: 1449-1459, ISSN: 1477-9226

JOURNAL ARTICLE

Cilibrizzi A, Collins J, Woscholski R, Leatherbarrow R, Vilar Ret al., 2014, New vanadium complexes as optical probes to detect Cys sulfenic modifications in PTEN, 12th European Biological Inorganic Chemistry Conference (EuroBIC), Publisher: SPRINGER, Pages: S873-S873, ISSN: 0949-8257

CONFERENCE PAPER

D'Arcy M, Bullough F, Moffat C, Borgomeo E, Teh M, Vilar R, Weiss DJet al., 2014, Adsorption of Oxy-Anions in the Teaching Laboratory: An Experiment To Study a Fundamental Environmental Engineering Problem, JOURNAL OF CHEMICAL EDUCATION, Vol: 91, Pages: 505-510, ISSN: 0021-9584

JOURNAL ARTICLE

Ghosh S, Mendoza O, Cubo L, Rosu F, Gabelica V, White AJP, Vilar Ret al., 2014, Assembly of Palladium(II) and Platinum(II) Metallo-Rectangles with a Guanosine-Substituted Terpyridine and Study of Their Interactions with Quadruplex DNA, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 20, Pages: 4772-4779, ISSN: 0947-6539

JOURNAL ARTICLE

Karim NHA, Mendoza O, Shivalingam A, Thompson AJ, Ghosh S, Kuimova MK, Vilar Ret al., 2014, Salphen metal complexes as tunable G-quadruplex binders and optical probes, RSC ADVANCES, Vol: 4, Pages: 3355-3363, ISSN: 2046-2069

JOURNAL ARTICLE

Leczkowska A, Vilar R, 2014, Targeting quadruplex nucleic acids with metal complexes, 16th International Conference on Biological Inorganic Chemistry (ICBIC), Publisher: SPRINGER, Pages: S378-S378, ISSN: 0949-8257

CONFERENCE PAPER

Moffat CD, Weiss DJ, Shivalingam A, White AJP, Salauen P, Vilar Ret al., 2014, Molecular Recognition and Scavenging of Arsenate from Aqueous Solution Using Dimetallic Receptors, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 20, Pages: 17168-17177, ISSN: 0947-6539

JOURNAL ARTICLE

Pujol A, Vilar R, 2014, Multimetallic and Bifunctional MRI-probes for imaging apoptotic cells., 16th International Conference on Biological Inorganic Chemistry (ICBIC), Publisher: SPRINGER, Pages: S620-S620, ISSN: 0949-8257

CONFERENCE PAPER

Sala R, Quang-De N, Patel CBK, Mann D, Steinke JHG, Vilar R, Aboagye EOet al., 2014, Phosphorylation Status of Thymidine Kinase 1 Following Antiproliferative Drug Treatment Mediates 3 '-Deoxy-3 '-[F-18]-Fluorothymidine Cellular Retention, PLOS ONE, Vol: 9, ISSN: 1932-6203

JOURNAL ARTICLE

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