155 results found
Bandeira S, Gonzalez-Garcia J, Pensa E, et al., 2018, A Redox-Activated G-Quadruplex DNA Binder Based on a Platinum(IV)-Salphen Complex., Angew Chem Int Ed Engl, Vol: 57, Pages: 310-313
There has been increasing interest in the development of small molecules that can selectively bind to G-quadruplex DNA structures. The latter have been associated with a number of key biological processes and therefore are proposed to be potential targets for drug development. Herein, we report the first example of a reduction-activated G-quadruplex DNA binder. We show that a new octahedral platinum(IV)-salphen complex does not interact with DNA in aqueous media at pH 7.4; however, upon addition of bioreductants such as ascorbic acid or glutathione, the compound is readily reduced to the corresponding square planar platinum(II) complex. In contrast to the parent platinum(IV) complex, the in situ generated platinum(II) complex has good affinity for G-quadruplex DNA.
Cowell S, Carroll L, Lavdas I, et al., 2018, Towards an MMP-2-activated molecular agent for cancer imaging., Dalton Trans
Matrix metalloproteinases (MMPs) have been identified as biomarkers for cancer, offering prognostic potential; however, non-invasive detection protocols are currently lacking. Herein, we describe the synthesis of a DOTA-containing peptide sequence that can be radiolabelled easily with 68Gallium or can be incorporated with gadolinium for possible MRI applications with clear selectivity for MMP-2 over other members of the MMP family, giving MMP-2 selective cleavage of the labelled peptides.
Cilibrizzi A, Fedorova M, Collins J, et al., 2017, A tri-functional vanadium(IV) complex to detect cysteine oxidation, DALTON TRANSACTIONS, Vol: 46, Pages: 6994-7004, ISSN: 1477-9226
Cilibrizzi A, Terenghi M, Fedorova M, et al., 2017, Small-molecule optical probes for cell imaging of protein sulfenylation and their application to monitor cisplatin induced protein oxidation, SENSORS AND ACTUATORS B-CHEMICAL, Vol: 248, Pages: 437-446, ISSN: 0925-4005
Markovic T, Manzoor S, Humphreys-Williams E, et al., 2017, Experimental Determination of Zinc Isotope Fractionation in Complexes with the Phytosiderophore 2 '-Deoxymugeneic Acid (DMA) and Its Structural Analogues, and Implications for Plant Uptake Mechanisms, ENVIRONMENTAL SCIENCE & TECHNOLOGY, Vol: 51, Pages: 98-107, ISSN: 0013-936X
Pyne ALB, Hoogenboom BW, Vilar R, et al., 2017, Visualisation of DNA conformational changes in situ at nanometre resolution, 19th IUPAB Congress / 11th EBSA Congress, Publisher: SPRINGER, Pages: S369-S369, ISSN: 0175-7571
Zhou C-Q, Liao T-C, Li Z-Q, et al., 2017, Dinickel-Salphen Complexes as Binders of Human Telomeric Dimeric G-Quadruplexes, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 23, Pages: 4713-4722, ISSN: 0947-6539
Ang DL, Harper BWJ, Cubo L, et al., 2016, Quadruplex DNA-Stabilising Dinuclear Platinum(II) Terpyridine Complexes with Flexible Linkers, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 22, Pages: 2317-2325, ISSN: 0947-6539
Ang DL, Harper BWJ, Cubo L, et al., 2016, Back Cover: Quadruplex DNA-Stabilising Dinuclear Platinum(II) Terpyridine Complexes with Flexible Linkers (Chem. Eur. J. 7/2016), Chemistry - A European Journal, Vol: 22, Pages: 2540-2540, ISSN: 0947-6539
Collins J, Cilibrizzi A, Fedorova M, et al., 2016, Vanadyl complexes with dansyl-labelled dipicolinic acid ligands: synthesis, phosphatase inhibition activity and cellular uptake studies, DALTON TRANSACTIONS, Vol: 45, Pages: 7104-7113, ISSN: 1477-9226
Gama S, Rodrigues I, Mendes F, et al., 2016, Anthracene-terpyridine metal complexes as new G-quadruplex DNA binders, JOURNAL OF INORGANIC BIOCHEMISTRY, Vol: 160, Pages: 275-286, ISSN: 0162-0134
Kotar A, Wang B, Shivalingam A, et al., 2016, NMR Structure of a Triangulenium-Based Long-Lived Fluorescence Probe Bound to a G-Quadruplex, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 55, Pages: 12508-12511, ISSN: 1433-7851
Shivalingam A, Vysniauskas A, Albrecht T, et al., 2016, Trianguleniums as Optical Probes for G-Quadruplexes: APhotophysical, Electrochemical, and Computational Study, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 22, Pages: 4129-4139, ISSN: 0947-6539
Turek VA, Francescato Y, Cadinu P, et al., 2016, Self-Assembled Spherical Supercluster Metamaterials from Nanoscale Building Blocks, ACS PHOTONICS, Vol: 3, Pages: 35-42, ISSN: 2330-4022
Vilar Compte R, Klejevskaja B, Pyne LBA, et al., 2016, Studies of G-quadruplexes formed within self-assembled DNA mini-circles, Chemical Communications (London), Vol: 52, Pages: 12454-12457, ISSN: 0009-241X
We have developed self-assembled DNA mini-circles that contain a G-quadruplex-forming sequence from the c-Myc oncogene promoter and demonstrate by FRET that the G-quadruplex unfolding kinetics are 10-fold slower than for the simpler 24-mer G-quadruplex that is commonly used for FRET experiments.
Wilson N, Mak LH, Cilibrizzi A, et al., 2016, A lipophilic copper(II) complex as an optical probe for intracellular detection of NO, DALTON TRANSACTIONS, Vol: 45, Pages: 18177-18182, ISSN: 1477-9226
Mendoza C, Jansat S, Vilar R, et al., 2015, Clickable complexing agents: functional crown ethers for immobilisation onto polymers and magnetic nanoparticles, RSC ADVANCES, Vol: 5, Pages: 87352-87363, ISSN: 2046-2069
Mion G, Gianferrara T, Bergamo A, et al., 2015, Phototoxic Activity and DNA Interactions of Water-Soluble Porphyrins and Their Rhenium(I) Conjugates, CHEMMEDCHEM, Vol: 10, Pages: 1901-1914, ISSN: 1860-7179
Shivalingam A, Izquierdo MA, Le Marois A, et al., 2015, The interactions between a small molecule and G-quadruplexes are visualized by fluorescence lifetime imaging microscopy, NATURE COMMUNICATIONS, Vol: 6, ISSN: 2041-1723
Ali SMH, Yan Y-K, Lee PPF, et al., 2014, Copper(II) complexes of substituted salicylaldehyde dibenzyl semicarbazones: synthesis, cytotoxicity and interaction with quadruplex DNA, DALTON TRANSACTIONS, Vol: 43, Pages: 1449-1459, ISSN: 1477-9226
Cilibrizzi A, Collins J, Woscholski R, et al., 2014, New vanadium complexes as optical probes to detect Cys sulfenic modifications in PTEN, 12th European Biological Inorganic Chemistry Conference (EuroBIC), Publisher: SPRINGER, Pages: S873-S873, ISSN: 0949-8257
D'Arcy M, Bullough F, Moffat C, et al., 2014, Adsorption of Oxy-Anions in the Teaching Laboratory: An Experiment To Study a Fundamental Environmental Engineering Problem, JOURNAL OF CHEMICAL EDUCATION, Vol: 91, Pages: 505-510, ISSN: 0021-9584
Ghosh S, Mendoza O, Cubo L, et al., 2014, Assembly of Palladium(II) and Platinum(II) Metallo-Rectangles with a Guanosine-Substituted Terpyridine and Study of Their Interactions with Quadruplex DNA, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 20, Pages: 4772-4779, ISSN: 0947-6539
Karim NHA, Mendoza O, Shivalingam A, et al., 2014, Salphen metal complexes as tunable G-quadruplex binders and optical probes, RSC ADVANCES, Vol: 4, Pages: 3355-3363, ISSN: 2046-2069
Leczkowska A, Vilar R, 2014, Targeting quadruplex nucleic acids with metal complexes, 16th International Conference on Biological Inorganic Chemistry (ICBIC), Publisher: SPRINGER, Pages: S378-S378, ISSN: 0949-8257
Moffat CD, Weiss DJ, Shivalingam A, et al., 2014, Molecular Recognition and Scavenging of Arsenate from Aqueous Solution Using Dimetallic Receptors, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 20, Pages: 17168-17177, ISSN: 0947-6539
Pujol A, Vilar R, 2014, Multimetallic and Bifunctional MRI-probes for imaging apoptotic cells., 16th International Conference on Biological Inorganic Chemistry (ICBIC), Publisher: SPRINGER, Pages: S620-S620, ISSN: 0949-8257
Sala R, Quang-De N, Patel CBK, et al., 2014, Phosphorylation Status of Thymidine Kinase 1 Following Antiproliferative Drug Treatment Mediates 3 '-Deoxy-3 '-[F-18]-Fluorothymidine Cellular Retention, PLOS ONE, Vol: 9, ISSN: 1932-6203
Stafford V, Shivalingam A, Suntharalingam K, et al., 2014, Interaction of metal complexes with G-quadruplex DNA and their effects on gene expression, 12th European Biological Inorganic Chemistry Conference (EuroBIC), Publisher: SPRINGER, Pages: S740-S740, ISSN: 0949-8257
Stafford VS, Suntharalingam K, Shivalingam A, et al., 2014, Syntheses of polypyridyl metal complexes and studies of their interaction with quadruplex DNA, Dalton Transactions, Vol: 44, Pages: 3686-3700, ISSN: 1477-9226
A series of mono- and bi-metallic metal complexes (with CuII, PtII and ZnII) with substituted polypyridylligands have been prepared and their binding affinities towards quadruplex (c-Myc and human telomeric)and duplex DNA (ds26 and calf thymus) determined using fluorescent indicator displacement (FID) assaysand UV/vis spectroscopic titrations. These studies have shown that the number of aromatic rings andnumber/position of cyclic amine substituents on the ligands, play an important role in defining the DNAbinding abilities of the resulting metal complexes. We also show that bi-metallic complexes preparedusing a novel terpyridine-cyclen ligand have higher affinity towards G-quadruplex DNA as compared totheir mono-metallic counterparts. Cytotoxicity assays were carried out for all the new complexes againstan osteosarcoma cancer cell line (U2OS) as well as a normal fibroblast cell line (GM05757). Several ofthese compounds displayed cytotoxicity similar to that of cisplatin.
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