Imperial College London

Prof. Ramon Vilar

Faculty of Natural SciencesDepartment of Chemistry

Professor of Medicinal Inorganic Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 1967r.vilar Website

 
 
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Location

 

RCS1-315ChemistrySouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

150 results found

Markovic T, Manzoor S, Humphreys-Williams E, Kirk GJD, Vilar R, Weiss DJet al., 2017, Experimental Determination of Zinc Isotope Fractionation in Complexes with the Phytosiderophore 2 '-Deoxymugeneic Acid (DMA) and Its Structural Analogues, and Implications for Plant Uptake Mechanisms, ENVIRONMENTAL SCIENCE & TECHNOLOGY, Vol: 51, Pages: 98-107, ISSN: 0013-936X

JOURNAL ARTICLE

Zhou CQ, Liao TC, Li ZQ, Gonzalez-Garcia J, Reynolds M, Zou M, Vilar Ret al., 2017, Dinickel-Salphen Complexes as Binders of Human Telomeric Dimeric G-Quadruplexes., Chemistry, Vol: 23, Pages: 4713-4722

Three new polyether-tethered dinickel-salphen complexes (2 a-c) have been synthesized and fully characterized by NMR spectroscopy, mass spectrometry, and elemental analyses. The binding affinity and selectivity of these complexes and of the parent mono-nickel complex (1) towards dimeric quadruplex DNA have been determined by UV/Vis titrations, fluorescence spectroscopy, CD spectroscopy, and electrophoresis. These studies have shown that the dinickel-salphen complex with the longest polyether linker (2 c) has higher binding affinity and selectivity towards dimeric quadruplexes (over monomeric quadruplexes) than the dinickel-salphen complexes with the shorter polyether linkers (2 a and 2 b). Complex 2 c also has higher selectivity towards human telomeric dimeric quadruplexes with one TTA linker than the monometallic complex 1. Based on the spectroscopic data, a possible binding mode between complex 2 c and the dimeric G-quadruplex DNA under study is proposed.

JOURNAL ARTICLE

Ang DL, Harper BWJ, Cubo L, Mendoza O, Vilar R, Aldrich-Wright Jet al., 2016, Quadruplex DNA-Stabilising Dinuclear Platinum(II) Terpyridine Complexes with Flexible Linkers, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 22, Pages: 2317-2325, ISSN: 0947-6539

JOURNAL ARTICLE

Ang DL, Harper BWJ, Cubo L, Mendoza O, Vilar R, Aldrich-Wright Jet al., 2016, Back Cover: Quadruplex DNA-Stabilising Dinuclear Platinum(II) Terpyridine Complexes with Flexible Linkers (Chem. Eur. J. 7/2016), Chemistry - A European Journal, Vol: 22, Pages: 2540-2540, ISSN: 0947-6539

JOURNAL ARTICLE

Collins J, Cilibrizzi A, Fedorova M, Whyte G, Mak LH, Guterman I, Leatherbarrow R, Woscholski R, Vilar Ret al., 2016, Vanadyl complexes with dansyl-labelled dipicolinic acid ligands: synthesis, phosphatase inhibition activity and cellular uptake studies, DALTON TRANSACTIONS, Vol: 45, Pages: 7104-7113, ISSN: 1477-9226

JOURNAL ARTICLE

Gama S, Rodrigues I, Mendes F, Santos IC, Gabano E, Klejevskaja B, Gonzalez-Garcia J, Ravera M, Vilar R, Paulo Aet al., 2016, Anthracene-terpyridine metal complexes as new G-quadruplex DNA binders, JOURNAL OF INORGANIC BIOCHEMISTRY, Vol: 160, Pages: 275-286, ISSN: 0162-0134

JOURNAL ARTICLE

Kotar A, Wang B, Shivalingam A, Gonzalez-Garcia J, Vilar R, Plavec Jet al., 2016, NMR Structure of a Triangulenium-Based Long-Lived Fluorescence Probe Bound to a G-Quadruplex, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 55, Pages: 12508-12511, ISSN: 1433-7851

JOURNAL ARTICLE

Shivalingam A, Vysniauskas A, Albrecht T, White AJP, Kuimova MK, Vilar Ret al., 2016, Trianguleniums as Optical Probes for G-Quadruplexes: APhotophysical, Electrochemical, and Computational Study, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 22, Pages: 4129-4139, ISSN: 0947-6539

JOURNAL ARTICLE

Turek VA, Francescato Y, Cadinu P, Crick CR, Elliott L, Chen Y, Urland V, Ivanov AP, Velleman L, Hong M, Vilar R, Maier SA, Giannini V, Edel JBet al., 2016, Self-Assembled Spherical Supercluster Metamaterials from Nanoscale Building Blocks, ACS PHOTONICS, Vol: 3, Pages: 35-42, ISSN: 2330-4022

JOURNAL ARTICLE

Vilar Compte R, Klejevskaja B, Pyne LBA, Reynolds M, Shivalingam A, Thorogate R, Hoogenboom BW, Ying Let al., 2016, Studies of G-quadruplexes formed within self-assembled DNA mini-circles, Chemical Communications (London), Vol: 52, Pages: 12454-12457, ISSN: 0009-241X

We have developed self-assembled DNA mini-circles that contain a G-quadruplex-forming sequence from the c-Myc oncogene promoter and demonstrate by FRET that the G-quadruplex unfolding kinetics are 10-fold slower than for the simpler 24-mer G-quadruplex that is commonly used for FRET experiments.

JOURNAL ARTICLE

Wilson N, Mak LH, Cilibrizzi A, Gee AD, Long NJ, Woscholski R, Vilar Ret al., 2016, A lipophilic copper(II) complex as an optical probe for intracellular detection of NO, DALTON TRANSACTIONS, Vol: 45, Pages: 18177-18182, ISSN: 1477-9226

JOURNAL ARTICLE

Mendoza C, Jansat S, Vilar R, Pericas MAet al., 2015, Clickable complexing agents: functional crown ethers for immobilisation onto polymers and magnetic nanoparticles, RSC ADVANCES, Vol: 5, Pages: 87352-87363, ISSN: 2046-2069

JOURNAL ARTICLE

Mion G, Gianferrara T, Bergamo A, Gasser G, Pierroz V, Rubbiani R, Vilar R, Leczkowska A, Alessio Eet al., 2015, Phototoxic Activity and DNA Interactions of Water-Soluble Porphyrins and Their Rhenium(I) Conjugates, CHEMMEDCHEM, Vol: 10, Pages: 1901-1914, ISSN: 1860-7179

JOURNAL ARTICLE

Shivalingam A, Izquierdo MA, Le Marois A, Vysniauskas A, Suhling K, Kuimova MK, Vilar Ret al., 2015, The interactions between a small molecule and G-quadruplexes are visualized by fluorescence lifetime imaging microscopy, NATURE COMMUNICATIONS, Vol: 6, ISSN: 2041-1723

JOURNAL ARTICLE

Ali SMH, Yan Y-K, Lee PPF, Khong KZX, Sk MA, Lim KH, Klejevskaja B, Vilar Ret al., 2014, Copper(II) complexes of substituted salicylaldehyde dibenzyl semicarbazones: synthesis, cytotoxicity and interaction with quadruplex DNA, DALTON TRANSACTIONS, Vol: 43, Pages: 1449-1459, ISSN: 1477-9226

JOURNAL ARTICLE

Cilibrizzi A, Collins J, Woscholski R, Leatherbarrow R, Vilar Ret al., 2014, New vanadium complexes as optical probes to detect Cys sulfenic modifications in PTEN, 12th European Biological Inorganic Chemistry Conference (EuroBIC), Publisher: SPRINGER, Pages: S873-S873, ISSN: 0949-8257

CONFERENCE PAPER

D'Arcy M, Bullough F, Moffat C, Borgomeo E, Teh M, Vilar R, Weiss DJet al., 2014, Adsorption of Oxy-Anions in the Teaching Laboratory: An Experiment To Study a Fundamental Environmental Engineering Problem, JOURNAL OF CHEMICAL EDUCATION, Vol: 91, Pages: 505-510, ISSN: 0021-9584

JOURNAL ARTICLE

Ghosh S, Mendoza O, Cubo L, Rosu F, Gabelica V, White AJP, Vilar Ret al., 2014, Assembly of Palladium(II) and Platinum(II) Metallo-Rectangles with a Guanosine-Substituted Terpyridine and Study of Their Interactions with Quadruplex DNA, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 20, Pages: 4772-4779, ISSN: 0947-6539

JOURNAL ARTICLE

Karim NHA, Mendoza O, Shivalingam A, Thompson AJ, Ghosh S, Kuimova MK, Vilar Ret al., 2014, Salphen metal complexes as tunable G-quadruplex binders and optical probes, RSC ADVANCES, Vol: 4, Pages: 3355-3363, ISSN: 2046-2069

JOURNAL ARTICLE

Leczkowska A, Vilar R, 2014, Targeting quadruplex nucleic acids with metal complexes, 16th International Conference on Biological Inorganic Chemistry (ICBIC), Publisher: SPRINGER, Pages: S378-S378, ISSN: 0949-8257

CONFERENCE PAPER

Moffat CD, Weiss DJ, Shivalingam A, White AJP, Salauen P, Vilar Ret al., 2014, Molecular Recognition and Scavenging of Arsenate from Aqueous Solution Using Dimetallic Receptors, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 20, Pages: 17168-17177, ISSN: 0947-6539

JOURNAL ARTICLE

Pujol A, Vilar R, 2014, Multimetallic and Bifunctional MRI-probes for imaging apoptotic cells., 16th International Conference on Biological Inorganic Chemistry (ICBIC), Publisher: SPRINGER, Pages: S620-S620, ISSN: 0949-8257

CONFERENCE PAPER

Sala R, Quang-De N, Patel CBK, Mann D, Steinke JHG, Vilar R, Aboagye EOet al., 2014, Phosphorylation Status of Thymidine Kinase 1 Following Antiproliferative Drug Treatment Mediates 3 '-Deoxy-3 '-[F-18]-Fluorothymidine Cellular Retention, PLOS ONE, Vol: 9, ISSN: 1932-6203

JOURNAL ARTICLE

Stafford V, Shivalingam A, Suntharalingam K, Mann D, Vilar Ret al., 2014, Interaction of metal complexes with G-quadruplex DNA and their effects on gene expression, 12th European Biological Inorganic Chemistry Conference (EuroBIC), Publisher: SPRINGER, Pages: S740-S740, ISSN: 0949-8257

CONFERENCE PAPER

Stafford VS, Suntharalingam K, Shivalingam A, White AJP, Mann DJ, Vilar Ret al., 2014, Syntheses of polypyridyl metal complexes and studies of their interaction with quadruplex DNA, Dalton Transactions, Vol: 44, Pages: 3686-3700, ISSN: 1477-9226

A series of mono- and bi-metallic metal complexes (with CuII, PtII and ZnII) with substituted polypyridylligands have been prepared and their binding affinities towards quadruplex (c-Myc and human telomeric)and duplex DNA (ds26 and calf thymus) determined using fluorescent indicator displacement (FID) assaysand UV/vis spectroscopic titrations. These studies have shown that the number of aromatic rings andnumber/position of cyclic amine substituents on the ligands, play an important role in defining the DNAbinding abilities of the resulting metal complexes. We also show that bi-metallic complexes preparedusing a novel terpyridine-cyclen ligand have higher affinity towards G-quadruplex DNA as compared totheir mono-metallic counterparts. Cytotoxicity assays were carried out for all the new complexes againstan osteosarcoma cancer cell line (U2OS) as well as a normal fibroblast cell line (GM05757). Several ofthese compounds displayed cytotoxicity similar to that of cisplatin.

JOURNAL ARTICLE

Zhou W, Vilar R, Ying L, Harding SEet al., 2014, Transcriptional regulatory roles of G-quadruplex DNA in promoters of genes involved in beta-adrenergic signaling pathway, CARDIOVASCULAR RESEARCH, Vol: 103, ISSN: 0008-6363

JOURNAL ARTICLE

Cowell S, Nguyen Q-D, Twyman F, Lavdas I, Carroll L, Vilar R, Aboagye Eet al., 2013, Towards multimodal molecular probes responsive to matrix metalloproteinases, JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, Vol: 56, Pages: S235-S235, ISSN: 0362-4803

JOURNAL ARTICLE

Ghosh S, Silber GT, White AJP, Robertson N, Vilar Ret al., 2013, Synthesis of a self-assembled copper(II) metallo-rectangle with a guanosine-substituted terpyridine, DALTON TRANSACTIONS, Vol: 42, Pages: 13813-13816, ISSN: 1477-9226

JOURNAL ARTICLE

Sala R, Quang-De N, Patel C, Mann D, Steinke JHG, Vilar R, Aboagye EOet al., 2013, Regulation of 18F-fluorothymidine uptake by thymidine kinase 1 protein phosphorylation., 104th Annual Meeting of the American-Association-for-Cancer-Research (AACR), Publisher: AMER ASSOC CANCER RESEARCH, ISSN: 0008-5472

CONFERENCE PAPER

Suntharalingam K, Mendoza O, Duarte AA, Mann DJ, Vilar Ret al., 2013, A platinum complex that binds non-covalently to DNA and induces cell death via a different mechanism than cisplatin, METALLOMICS, Vol: 5, Pages: 514-523, ISSN: 1756-5901

JOURNAL ARTICLE

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