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@article{Bandeira:2018:10.1002/ange.201709968,
author = {Bandeira, S and GonzalezGarcia, J and Pensa, E and Albrecht, T and Vilar, R},
doi = {10.1002/ange.201709968},
journal = {Angewandte Chemie},
pages = {316--319},
title = {A RedoxActivated GQuadruplex DNA Binder Based on a Platinum(IV)–Salphen Complex},
url = {http://dx.doi.org/10.1002/ange.201709968},
volume = {130},
year = {2018}
}

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TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:p>There has been increasing interest in the development of small molecules that can selectively bind to Gquadruplex DNA structures. The latter have been associated with a number of key biological processes and therefore are proposed to be potential targets for drug development. Herein, we report the first example of a reductionactivated Gquadruplex DNA binder. We show that a new octahedral platinum(IV)–salphen complex does not interact with DNA in aqueous media at pH7.4; however, upon addition of bioreductants such as ascorbic acid or glutathione, the compound is readily reduced to the corresponding square planar platinum(II) complex. In contrast to the parent platinum(IV) complex, the insitu generated platinum(II) complex has good affinity for Gquadruplex DNA.</jats:p>
AU  - Bandeira,S
AU  - GonzalezGarcia,J
AU  - Pensa,E
AU  - Albrecht,T
AU  - Vilar,R
DO  - 10.1002/ange.201709968
EP  - 319
PY  - 2018///
SN  - 0044-8249
SP  - 316
TI  - A RedoxActivated GQuadruplex DNA Binder Based on a Platinum(IV)–Salphen Complex
T2  - Angewandte Chemie
UR  - http://dx.doi.org/10.1002/ange.201709968
VL  - 130
ER  -

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Prof. Ramon Vilar

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