Imperial College London
Alternate

DrRachelSmith

Faculty of Medicine, School of Public Health

Research Fellow in Population Child Health
 
 
 
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Contact

 

+44 (0)20 7594 3313rachel.smith05

 
 
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Location

 

527Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Pedersen:2015:10.1289/ehp.1408613,
author = {Pedersen, M and Mendez, MA and Schoket, B and Godschalk, RW and Espinosa, A and Landstrom, A and Villanueva, CM and Merlo, DF and Fthenou, E and Gracia-Lavedan, E and van, Schooten F-J and Hoek, G and Brunborg, G and Meltzer, HM and Alexander, J and Nielsen, JK and Sunyer, J and Wright, J and Kovacs, K and de, Hoogh K and Gutzkow, KB and Hardie, LJ and Chatzi, L and Knudsen, LE and Anna, L and Ketzel, M and Haugen, M and Botsivali, M and Nieuwenhuijsen, MJ and Cirach, M and Toledano, MB and Smith, RB and Fleming, S and Agramunt, S and Kyrtopoulos, SA and Lukacs, V and Kleinjans, JC and Segerback, D and Kogevinas, M},
doi = {10.1289/ehp.1408613},
journal = {Environmental Health Perspectives},
pages = {374--380},
title = {Environmental, dietary, maternal, and fetal predictors of bulky DNA adducts in cord blood: a European mother-child study (NewGeneris)},
url = {http://dx.doi.org/10.1289/ehp.1408613},
volume = {123},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background:  Bulky  DNA  adducts  reflect  genotoxic  exposures,  have  been  associated  with  lower  birth weight, and may predict cancer risk.oBjective:  We  selected  factors  known  or  hypothesized  to  affect  inutero  adduct  formation  and  repair and examined their associations with adduct levels in neonates.Methods:  Pregnant  women  from  Greece,  Spain,  England,  Denmark,  and  Norway  were  recruited  in  2006–2010.  Cord  blood  bulky  DNA  adduct  levels  were  measured  by  the  32P-postlabeling technique  (n=511).  Diet  and  maternal  characteristics  were  assessed  via  questionnaires.  Modeled  exposures  to  air  pollutants  and  drinking-water  disinfection  by-products,  mainly  trihalomethanes  (THMs), were available for a large proportion of the study population.results:  Greek  and  Spanish  neonates  had  higher  adduct  levels  than  the  northern  European  neonates  [median,  12.1  (n=179)  vs.  6.8  (n=332)  adducts  per  108  nucleotides,  p<0.001].Residence  in  southern  European  countries,  higher  maternal  body  mass  index,  delivery  by  cesarean  section,  male  infant  sex,  low  maternal  intake  of  fruits  rich  in  vitaminC,  high  intake  of  dairyproducts,  and  low  adherence  to  healthy  diet  score  were  statistically  significantly  associated  with  higher  adduct  levels  in  adjusted  models.  Exposure  to  fine  particulate  matter  and  nitrogen  dioxide  was associated with significantly higher adducts in the Danish subsample only. Overall, the pooled results for THMs in water show no evidence of association with adduct levels; however, there are country-specific differences in results with a suggestion of an association in England.conclusion:  These  findings  suggest  that  a  combination  of  factors,  including  unknown  country-specific factors, influence the bulky DNA adduct levels in neonates.citation: Pedersen M, Mendez MA, Schoket B, Godschalk RW, Espinosa A, LandströmA, Villanueva
AU  - Pedersen,M
AU  - Mendez,MA
AU  - Schoket,B
AU  - Godschalk,RW
AU  - Espinosa,A
AU  - Landstrom,A
AU  - Villanueva,CM
AU  - Merlo,DF
AU  - Fthenou,E
AU  - Gracia-Lavedan,E
AU  - van,Schooten F-J
AU  - Hoek,G
AU  - Brunborg,G
AU  - Meltzer,HM
AU  - Alexander,J
AU  - Nielsen,JK
AU  - Sunyer,J
AU  - Wright,J
AU  - Kovacs,K
AU  - de,Hoogh K
AU  - Gutzkow,KB
AU  - Hardie,LJ
AU  - Chatzi,L
AU  - Knudsen,LE
AU  - Anna,L
AU  - Ketzel,M
AU  - Haugen,M
AU  - Botsivali,M
AU  - Nieuwenhuijsen,MJ
AU  - Cirach,M
AU  - Toledano,MB
AU  - Smith,RB
AU  - Fleming,S
AU  - Agramunt,S
AU  - Kyrtopoulos,SA
AU  - Lukacs,V
AU  - Kleinjans,JC
AU  - Segerback,D
AU  - Kogevinas,M
DO  - 10.1289/ehp.1408613
EP  - 380
PY  - 2015///
SN  - 0091-6765
SP  - 374
TI  - Environmental, dietary, maternal, and fetal predictors of bulky DNA adducts in cord blood: a European mother-child study (NewGeneris)
T2  - Environmental Health Perspectives
UR  - http://dx.doi.org/10.1289/ehp.1408613
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000352168000024&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/53119
VL  - 123
ER  -
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