Imperial College London
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Prof. Dr. Tobias Reichenbach

Faculty of Engineering, Department of Bioengineering

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 6370reichenbach Website

 
 
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Location

 

4.12Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ota:2020:10.1007/s00424-020-02373-6,
author = {Ota, T and Nin, F and Choi, S and Muramatsu, S and Sawamura, S and Ogata, G and Sato, MP and Doi, K and Doi, K and Tsuji, T and Kawano, S and Reichenbach, J and Hibino, H},
doi = {10.1007/s00424-020-02373-6},
journal = {Pflügers Archiv European Journal of Physiology},
pages = {625--635},
title = {Characterisation of the static offset in the travelling wave in the cochlear basal turn},
url = {http://dx.doi.org/10.1007/s00424-020-02373-6},
volume = {472},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In mammals, audition is triggered by travelling waves that are evoked by acoustic stimuli in the cochlear partition, a structure containing sensory hair cells and a basilar membrane. When the cochlea is stimulated by a pure tone of low frequency, a static offset occurs in the vibration in the apical turn. In the high-frequency region at the cochlear base, multi-tone stimuli induce a quadratic distortion product in the vibrations that suggests the presence of an offset. However, vibrations below 100 Hz, including a static offset, have not been directly measured there. We therefore constructed an interferometer for detecting motion at low frequencies including 0 Hz. We applied the interferometer to record vibrations from the cochlear base of guinea pigs in response to pure tones. When the animals were exposed to sound at an intensity of 70 dB or higher, we recorded a static offset of the sinusoidally vibrating cochlear partition by more than 1 nm towards the scala vestibuli. The offset’s magnitude grew monotonically as the stimuli intensified. When stimulus frequency was varied, the response peaked around the best frequency, the frequency that maximised the vibration amplitude at threshold sound pressure. These characteristics are consistent with those found in the low-frequency region and are therefore likely common across the cochlea. The offset diminished markedly when the somatic motility of mechanosensitive outer hair cells, the force-generating machinery that amplifies the sinusoidal vibrations, was pharmacologically blocked. Therefore, the partition offset appears to be linked to the electromotile contraction of outer hair cells.
AU  - Ota,T
AU  - Nin,F
AU  - Choi,S
AU  - Muramatsu,S
AU  - Sawamura,S
AU  - Ogata,G
AU  - Sato,MP
AU  - Doi,K
AU  - Doi,K
AU  - Tsuji,T
AU  - Kawano,S
AU  - Reichenbach,J
AU  - Hibino,H
DO  - 10.1007/s00424-020-02373-6
EP  - 635
PY  - 2020///
SN  - 0031-6768
SP  - 625
TI  - Characterisation of the static offset in the travelling wave in the cochlear basal turn
T2  - Pflügers Archiv European Journal of Physiology
UR  - http://dx.doi.org/10.1007/s00424-020-02373-6
UR  - http://hdl.handle.net/10044/1/78992
VL  - 472
ER  -
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