Dr. Richie Abel joined the Department of Surgery and Cancer in December 2010. Richie is interested in studying bone quality, with particular regard to tissue development and senescence. The general aim is to improve the diagnosis and measurement of treatment outcomes for metabolic bone diseases.
Recent research published in Nature reveals that in some patients long-term treatment with the frontline therapy for osteoporosis (bisphosphonate) might actually weaken bones. Read about it on The Guardian and The BBC.
Richie is researching bone quality: the material and structural basis for bone quality. Current research includes developing novel metrics for bone quality by measuring structural, metabolic, material and mechanical properties.
Developing state of the art 3D imaging techniques such as clinical-, micro- and synchrotron-CT to visualise the hierarchical structure of bone at the gross, micron and submicron levels respectively. Applying serum blood analysis to measure bone formation and resorption. As well as mechanically testing bone samples to measure mechanical properties (e.g. strength, stiffness and fracture toughness).
The metrics are used to assess the effects of aging, lifestyle and pharmacologic agents on bone health e.g. bisphosphonates and cancer treatments such as ADT. More recently Richie has been testing the usefulness of nano- and micro-indenters for assessing the quality of a patients bone in vivo.
As yet virtually all of the metrics, except biochemical markers, are collected ex vivo. Richie is working to identify and test devices that could be used in vivo to diagnose disease, monitor progression and evaluate treatment outcomes. The metrics could also be used to asses the efficacy of novel treatment for bone disease.
et al., 2013, Fracture after androgen deprivation therapy among men with a high baseline risk of skeletal complications, Bjui, Vol:112, Pages:E431-E433
Abel RL, Laurini C, Richter M, 2012, A biologist's guide to ‘virtual’ micro-CT preparation, Palaeontologia Electronica, Vol:15, Pages:1-16
Macho GA, Abel RL, Schutkowski H, 2005, Age changes in bone microstructure: Do they occur uniformly?, International Journal of Osteoarchaeology, Vol:15, ISSN:1047-482X, Pages:421-430
et al., 2011, Brief Report: AIP Mutation in Pituitary Adenomas in the 18th Century and Today., New England Journal of Medicine, Vol:364, ISSN:0028-4793, Pages:43-50
et al., 2010, An Exploratory Study on the Combined Effects of External and Internal Morphology on Load Dissipation in Primate Capitates: Its Potential for an Understanding of the Positional and Locomotor Repertoire of Early Hominins, Folia Primatologica, Vol:81, ISSN:0015-5713, Pages:292-304
et al., 2006, Automated method to measure trabecular thickness from microcomputed tomographic scans and its application, Anatomical Record Part A-Discoveries in Molecular Cellular and Evolutionary Biology, Vol:288A, ISSN:1552-4884, Pages:982-988
Reissis D, Abel RL, 2012, Development of fetal trabecular micro-architecture in the humerus and femur, Journal of Anatomy, Vol:220, ISSN:0021-8782, Pages:496-503
et al., 2010, Early Pleistocene human occupation at the edge of the boreal zone in northwest Europe, Nature, Vol:466, ISSN:0028-0836, Pages:229-233
Abel R, Macho GA, 2011, Ontogenetic changes in the internal and external morphology of the ilium in modern humans, Journal of Anatomy, Vol:218, ISSN:0021-8782, Pages:324-335