Imperial College London

DrRichardAbel

Faculty of MedicineDepartment of Surgery & Cancer

Lecturer in Musculoskeletal Sciences
 
 
 
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Contact

 

richard.abel

 
 
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Location

 

Charing Cross HospitalCharing Cross Campus

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Summary

 

Publications

Publication Type
Year
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52 results found

Arnold M, Zhao S, Ma S, Giuliani F, Hansen U, Cobb JP, Abel RL, Boughton ORet al., Microindentation: a tool for measuring cortical bone stiffness? A systematic review, Bone & Joint Research, ISSN: 2046-3758

Objectives: Microindentation hasthe potential to measuretheelasticity(stiffness)of individualpatients’bone. Bone elasticity plays a crucial role in the press-fit stability of orthopaedic implants.Arming surgeons with accuratebone elasticityinformation may reduce surgical complicationsincluding peri-prosthetic fractures. The question we address with this systematicreview is whether microindentation can accurately measure cortical bone stiffness.Methods: A systematic review of all English language articles using a keyword search was undertaken in Medline, Embase, PubMed, Scopus and Cochrane databases. Studies thatonly used nanoindentation, cancellous boneoranimal tissue were excluded.Results: 1094abstracts were retrieved and 32papers were included in the analysis, 20 of which used reference point indentation and 12of which used traditional depth sensing indentation.There are a number of factors thatmust be taken into account when using microindentation such as tip size, depth and method of analysis.Only two studies validated microindentation againsttraditional mechanical testing techniques. Bothstudies used reference point indentation(RPI) with one showing that RPI parameters correlate well with mechanical testing, butanother suggestedthatthey do not. Conclusion: Microindentation has been used in various studies to assess bone elasticity but only two studies with conflicting results compared microindentation to traditional mechanical testing techniques. Further research,includingmore studies comparingmicroindentationto other mechanical testing methodsare needed,before microindentation can be reliably used to calculate cortical bone stiffness.

JOURNAL ARTICLE

Brewer P, Hand SJ, Archer M, Abel RLet al., New genus of primitive wombat (Vombatidae,Marsupialia) from Miocene deposits in the RiversleighWorld Heritage Area (Queensland, Australia), Palaeontologia Electronica

JOURNAL ARTICLE

Jin A, Cobb JP, Hansen U, Bhattacharya R, Reinhard C, Vo N, Atwood R, Li J, Abel RLet al., The effect of long term bisphosphonate therapy on trabecular bone strength and microcrack density, Bone & Joint Research, ISSN: 2046-3758

ObjectivesBisphosphonates (BP) are the first-line treatment for preventing fragility fractures. However, concern regarding the efficacy is growing because bisphosphonate is associated with over-suppression of remodelling and accumulation of microcracks. While DEXA scanning may show a gain in bone density the impact of this class of drug on mechanical properties remains unclear. We therefore sought to quantify the mechanical strength of bone treated with BP (oral alendronate for this study), and correlate this with the microarchitecture and density of microcracks in comparison with untreated controls. MethodsTrabecular bone from hip-fracture patients treated with BP (n=10) was compared to naïve fractured (n=14) and non-fractured controls (n=6). Trabecular cores were synchrotron and micro-CT scanned for microstructural analysis including quantification of bone volume fraction, micro-architecture and microcracks, then mechanically tested in compression. ResultsBP bone was 28% lower in strength than untreated hip-fracture bone and 48% lower in strength than and non-fracture control bone (4.6 vs 6.4 vs 8.9 MPa). BP treated bone had 24% more microcracks than naïve fractured bone and 51% more than non-fractured control (8.12 vs 6.55 vs 5.25 /cm2). BP and naïve fracture bone exhibited similar trabecular microarchitecture, with significantly lower bone volume fraction and connectivity than non-fractured controls. ConclusionsBP therapy had no detectable mechanical benefit. Instead its use was associated with substantially reduced bone strength. This low strength was probably due to the greater accumulation of microcracks and a lack of any discernible improvement in bone volume or microarchitecture. This preliminary study suggests that the clinical impact of BP induced microcrack accumulation may be substantial and long term.

JOURNAL ARTICLE

Boughton OR, Zhao S, Arnold M, Ma S, Cobb JP, Giuliani F, Hansen U, Abel RLet al., 2017, Measuring bone stiffness using microindentation, British Orthopaedic Research Society (BORS) 2016 Conference, Publisher: British Editorial Society of Bone and Joint Surgery, Pages: 31-31, ISSN: 2049-4416

CONFERENCE PAPER

Ma S, Goh EL, Jin A, Bhattacharya R, Boughton OR, Patel B, Karunaratne A, Vo NT, Atwood R, Cobb JP, Hansen U, Abel RLet al., 2017, Long-term effects of bisphosphonate therapy: perforations, microcracks and mechanical properties, SCIENTIFIC REPORTS, Vol: 7, ISSN: 2045-2322

JOURNAL ARTICLE

Agbesi MPK, Borsuk HS, Hunt JN, Maclaine JS, Abel RL, Sykes D, Ramsey AT, Wang Z, Cox JPLet al., 2016, Motion-driven flow in an unusual piscine nasal region, Zoology, Vol: 119, Pages: 500-510, ISSN: 0944-2006

JOURNAL ARTICLE

Cole JM, Wood JC, Lopes NC, Poder K, Abel RL, Alatabi S, Bryant JSJ, Jin A, Kneip S, Mecseki K, Parker S, Symes DR, Sandholzer MA, Mangles SPD, Najmudin Zet al., 2016, Tomography of human trabecular bone with a laser-wakefield driven x-ray source, PLASMA PHYSICS AND CONTROLLED FUSION, Vol: 58, ISSN: 0741-3335

JOURNAL ARTICLE

Coudrillier B, Geraldes DM, Vo NT, Atwood R, Reinhard C, Campbell IC, Raji Y, Albon J, Abel RL, Ethier CRet al., 2016, Phase-Contrast Micro-Computed Tomography Measurements of the Intraocular Pressure-Induced Deformation of the Porcine Lamina Cribrosa, Publisher: IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC, Pages: 988-999, ISSN: 0278-0062

CONFERENCE PAPER

Langley RE, Kynaston HG, Alhasso AA, Trinh D, Paez EM, Jovic G, Scrase CD, Robertson A, Cafferty F, Welland A, Carpenter R, Honeyfield L, Abel RL, Stone M, Parmar MKB, Abel PDet al., 2016, A Randomised Comparison Evaluating Changes in Bone Mineral Density in Advanced Prostate Cancer: Luteinising Hormone-releasing Hormone Agonists Versus Transdermal Oestradiol, EUROPEAN UROLOGY, Vol: 69, Pages: 1016-1025, ISSN: 0302-2838

JOURNAL ARTICLE

Ma S, Boughton O, Karunaratne A, Jin A, Cobb J, Hansen U, Abel Ret al., 2016, Synchrotron Imaging Assessment of Bone Quality, CLINICAL REVIEWS IN BONE AND MINERAL METABOLISM, Vol: 14, Pages: 150-160, ISSN: 1534-8644

JOURNAL ARTICLE

Ma S, Goh EL, Patel B, Jin A, Boughton O, Cobb J, Hansen U, Abel RLet al., 2016, Are the cracks starting to appear in bisphosphonate therapy?, British Orthopaedic Research Society (BORS) 2016 Conference, Publisher: British Editorial Society of Bone and Joint Surgery, Pages: 53-53, ISSN: 2049-4416

CONFERENCE PAPER

Smith DB, Bernhardt G, Raine NE, Abel RL, Sykes D, Ahmed F, Pedroso I, Gill RJet al., 2016, Exploring miniature insect brains using micro-CT scanning techniques, Scientific Reports, Vol: 6

JOURNAL ARTICLE

Acquaah F, Robson Brown KA, Ahmed F, Jeffery N, Abel RLet al., 2015, Early Trabecular Development in Human Vertebrae: Overproduction, Constructive Regression, and Refinement, Frontiers in Endocrinology, Vol: 6

JOURNAL ARTICLE

Campbell IC, Coudrillier B, Mensah J, Abel RL, Ethier CRet al., 2015, Automated segmentation of the lamina cribrosa using Frangi's filter: a novel approach for rapid identification of tissue volume fraction and beam orientation in a trabeculated structure in the eye, JOURNAL OF THE ROYAL SOCIETY INTERFACE, Vol: 12, ISSN: 1742-5689

JOURNAL ARTICLE

Cole JM, Wood JC, Lopes NC, Poder K, Abel RL, Alatabi S, Bryant JSJ, Jin A, Kneip S, Mecseki K, Symes DR, Mangles SPD, Najmudin Zet al., 2015, Laser-wakefield accelerators as hard x-ray sources for 3D medical imaging of human bone, SCIENTIFIC REPORTS, Vol: 5, ISSN: 2045-2322

JOURNAL ARTICLE

Wilson HCP, Shah SIA, Abel PD, Price P, Honeyfield L, Edwards S, Abel RLet al., 2015, Contemporary hormone therapy with LHRH agonists for prostate cancer: avoiding osteoporosis and fracture, CENTRAL EUROPEAN JOURNAL OF UROLOGY, Vol: 68, Pages: 165-168, ISSN: 2080-4806

JOURNAL ARTICLE

Fletcher A, Pearson J, Molleson T, Abel R, Ambers J, Wiles CCet al., 2014, Beneath the surface: imaging techniques and the Jericho Skull, Regarding the Dead Human Remains in the British Museum, Editors: Fletcher, Antoine, Hill, Publisher: British Museum Publications Limited, ISBN: 9780861591978

A key publication on the British Museum's approach to the ethical issues surrounding the inclusion of human remains in museum collections and possible solutions to the dilemmas relating to their curation, storage, access management and ...

BOOK CHAPTER

Fletcher A, Pearson J, Molleson T, Abel R, Ambers J, Wiles CCRet al., 2014, Beneath the surface: imaging techniques and the Jericho Skull, Regarding the Dead Human Remains in the British Museum, Publisher: British Museum Publications Limited, ISBN: 9780861591978

A key publication on the British Museum's approach to the ethical issues surrounding the inclusion of human remains in museum collections and possible solutions to the dilemmas relating to their curation, storage, access management and ...

BOOK CHAPTER

Goetz AJ, Griesshaber E, Abel R, Fehr T, Ruthensteiner B, Schmahl WWet al., 2014, Tailored order: The mesocrystalline nature of sea urchin teeth, Acta Biomaterialia, Vol: 10, Pages: 3885-3898, ISSN: 1742-7061

JOURNAL ARTICLE

Abel RL, Prime M, Jin A, Cobb JP, Bhattacharya Ret al., 2013, 3D Imaging Bone Quality: Bench to Bedside, Hard Tissue, Vol: 2

JOURNAL ARTICLE

Abel RL, Shah SIA, Langley RE, Cafferty FH, Abel RL, Abel PDet al., 2013, Fracture after androgen deprivation therapy among men with a high baseline risk of skeletal complications, BJUI, Vol: 112, Pages: E431-E433

JOURNAL ARTICLE

Hezel DC, Elangovan P, Viehmann S, Howard L, Abel RL, Armstrong Ret al., 2013, Visualisation and quantification of CV chondrite petrography using micro-tomography, Geochimica et Cosmochimica Acta, Vol: 116, Pages: 33-40, ISSN: 0016-7037

JOURNAL ARTICLE

Howard LE, Holmes WM, Ferrando S, Maclaine JS, Kelsh RN, Ramsey A, Abel RL, Cox JPLet al., 2013, Functional nasal morphology of chimaerid fishes, Journal of Morphology, Vol: 274, Pages: 987-1009, ISSN: 0362-2525

JOURNAL ARTICLE

Needham AW, Abel RL, Tomkinson T, Grady MMet al., 2013, Martian subsurface fluid pathways and 3D mineralogy of the Nakhla meteorite, Geochimica et Cosmochimica Acta, Vol: 116, Pages: 96-110, ISSN: 0016-7037

JOURNAL ARTICLE

Rygg AD, Cox JPL, Abel R, Webb AG, Smith NB, Craven BAet al., 2013, A Computational Study of the Hydrodynamics in the Nasal Region of a Hammerhead Shark (Sphyrna tudes): Implications for Olfaction, PLoS ONE, Vol: 8, Pages: e59783-e59783

JOURNAL ARTICLE

Walsh SA, Iwaniuk AN, Knoll MA, Bourdon E, Barrett PM, Milner AC, Nudds RL, Abel RL, Sterpaio PDet al., 2013, Avian Cerebellar Floccular Fossa Size Is Not a Proxy for Flying Ability in Birds, PLoS ONE, Vol: 8, Pages: e67176-e67176

JOURNAL ARTICLE

Abel RL, Laurini C, Richter M, 2012, A biologist's guide to ‘virtual’ micro-CT preparation, Palaeontologia Electronica, Vol: 15, Pages: 1-16

JOURNAL ARTICLE

Elangovan P, Hezel DC, Howard L, Armstrong R, Abel RLet al., 2012, PhaseQuant: A tool for quantifying tomographic data sets of geological specimens, Computers & Geosciences, Vol: 48, Pages: 323-329, ISSN: 0098-3004

JOURNAL ARTICLE

Paredes UM, Prys-Jones R, Adams M, Groombridge J, Kundu S, Agapow P-M, Abel RLet al., 2012, Micro-CT X-rays do not fragment DNA in preserved bird skins, JOURNAL OF ZOOLOGICAL SYSTEMATICS AND EVOLUTIONARY RESEARCH, Vol: 50, Pages: 247-250, ISSN: 0947-5745

JOURNAL ARTICLE

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