I have been a lecturer in the Section of Molecular Virology at Imperial College London since September 2012. My research programme aims to investigate the intersection between Epstein-Barr virus (EBV) diversity, mutation and pathogenesis, and also to identify the contributions of the EBV nuclear antigen leader protein (EBNA-LP) to the establishement of EBV latency. I was previously a postdoc in Professor Martin Allday's group investigating the role of the Epstein-Barr virus EBNA3 proteins in the transformation of B-cells and oncogenesis. I completed my PhD in Oxford in 2000, and then studied Herpesvirus Saimiri with Professor Adrian Whitehouse at the University of Leeds before moving to Imperial in 2003.
Regulation of the host cell transcriptome by EBV.
We (and others) have previously generated genetic mutants of the EBV nuclear antigens (EBNAs) 3A, 3B, 3C and 2. Our transcriptomic analysis of cell lines carrying these genetic variants is available at www.epstein-barrvirus.org.uk. These data are a searchable by gene name, with the hope that other researchers can identify EBV genes that may be associated with phenomena they may observe. Future data sets will be added once they are published or deemed non-confidential.
This resource is intended to be open for the research community, and anyone wishing to have their data added should contact me, and I will endeavour to do add it, subject to the limitations of my website programming skills.
I have a position available for up to 3 years, funded by the MRC, for a Postdoctoral research associate, to start sometime in the first half of 2016, to study the biology of EBV diversity. The application deadline is March 13th 2016, and applications should be made via the Imperial College job site using the job reference HM2016028. Please feel free to enquire by email for more details.
Enquiries from prospective students with independent funding (or with the potential to obtain such funding) are welcomed at any time. Funded PhD opportunities are available through schemes operated at a college-wide level, such as the Wellcome Trust-funded 'Molecular and cellular basis of infection' PhD scheme, the MRC scheme (operated centrally by Imperial College Faculty of Medicine), the BBSRC-DTP scheme, and the College-funded PhD studentship programme. Note that the BBSRC and MRC schemes are fully funded only for British citizens. Schemes typically take applications annually around November-January to begin in the following September/October. Other possible sources of funding are described here.
et al., 2015, Genome Diversity of Epstein-Barr Virus from Multiple Tumor Types and Normal Infection, Journal of Virology, Vol:89, ISSN:0022-538X, Pages:5222-5237
Allday MJ, Bazot Q, White RE, 2015, The EBNA3 Family: Two Oncoproteins and a Tumour Suppressor that Are Central to the Biology of EBV in B Cells, Epstein Barr Virus, Vol 2: One Herpes Virus: Many Diseases, Vol:391, ISSN:0070-217X, Pages:61-117
et al., 2013, Induction of p16(INK4a) Is the Major Barrier to Proliferation when Epstein-Barr Virus (EBV) Transforms Primary B Cells into Lymphoblastoid Cell Lines, Plos Pathogens, Vol:9, ISSN:1553-7374
et al., 2012, BIM promoter directly targeted by EBNA3C in polycomb-mediated repression by EBV, Nucleic Acids Research, Vol:40, ISSN:0305-1048, Pages:7233-7246
et al., 2012, EBNA3B-deficient EBV promotes B cell lymphomagenesis in humanized mice and is found in human tumors, Journal of Clinical Investigation, Vol:122, ISSN:0021-9738, Pages:1487-1502